Lorentz Microscopy of Permalloy Film Microdots

The results of an investigation into square permalloy film microdots with a quasivortical magnetic structure by the method of Lorentz electron microscopy are presented. The found before mechanism of the switching of microdot chirality in homogeneous plane magnetic field is discussed. The calculations are performed to evaluate the interaction of microdots under switching chirality.Приводятся результаты изучения методом лоренцевой электронной микроскопии квадратных пермаллоевых плёночных микропятен с квазивихревой магнитной структурой. Обсуждается механизм обнаруженного ранее эффекта переключения киральности пятна в однородном плоскостном магнитном поле. Выполнен расчёт по оценке взаимного влияния микропятен при переключении киральности

Lorentz Microscopy of Permalloy Film Microdots

The results of an investigation into square permalloy film microdots with a quasivortical magnetic structure by the method of Lorentz electron microscopy are presented. The found before mechanism of the switching of microdot chirality in homogeneous plane magnetic field is discussed. The calculations are performed to evaluate the interaction of microdots under switching chirality.Приводятся результаты изучения методом лоренцевой электронной микроскопии квадратных пермаллоевых плёночных микропятен с квазивихревой магнитной структурой. Обсуждается механизм обнаруженного ранее эффекта переключения киральности пятна в однородном плоскостном магнитном поле. Выполнен расчёт по оценке взаимного влияния микропятен при переключении киральности

Safety and Immunogenicity of Inactivated Whole Virion COVID-19 Vaccine CoviVac in Clinical Trials in 18–60 and 60+ Age Cohorts

We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, safety, and immunogenicity of the inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18–60 and open multi-center comparative phase IIb clinical trial in volunteers aged 60 years and older. The safety of the vaccine was assessed in 400 volunteers in the 18–60 age cohort who received two doses of the vaccine (n = 300) or placebo (n = 100) and in 200 volunteers in 60+ age cohort all of whom received three doses of the vaccine. The studied vaccine has shown good tolerability and safety. No deaths, serious adverse events (AEs), or other significant AEs related to vaccination have been detected. The most common AE in vaccinated participants was pain at the injection site (p p 1:256, the rate of fourfold increase in nAB levels was below 45%; the participants who were seropositive at screening of the 2nd vaccination did not lead to a significant increase in nAB titers. In conclusion, inactivated vaccine CoviVac has shown good tolerability and safety, with over 85% NT seroconversion rates after complete vaccination course in participants who were seronegative at screening in both age groups: 18–60 and 60+. In participants who were seropositive at screening and had nAB titers below 1:256, a single vaccination led to a fourfold increase in nAB levels in 85.2% of cases. These findings indicate that CoviVac can be successfully used both for primary vaccination in a two-dose regimen and for booster vaccination as a single dose in individuals with reduced neutralizing antibody levels

Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, E>100GeV E > 100 G e V ) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system