1,493 research outputs found
Kinetic Investigation of Polyurethane Rubber Formation from CO2âContaining Polyols
A novel CO2 utilization technology allows for the inclusion of CO2 as carbonate units and double bond moieties to give additional functionality in polyether polyols. This study examines the chainâelongation kinetics of these diols with diisocyanates to polyurethane rubbers by means of thermal analysis. A reaction order of 1 indicates a strong influence of the chains' mobility on the reaction rate. Spectrometry and comparison with nonâdoubleâbond polyols reveal that the effect cannot be attributed to a substantial occurrence of side reactions but is rather due to the intertwining of lengthy chains.BMBF, 033R350AâD, Production DreamsTU Berlin, Open-Access-Mittel - 202
Evaluation der hÀmodynamischen Eigenschaften von Aortenklappenprothesen und Vergleich zwischen Echokardiographie und invasiver Druckmessung in der Beurteilung von Aortenklappenprothesen
Die vorliegende Arbeit gliedert sich in zwei Teile:
1. Intraoperativer und postoperativer Vergleich der hĂ€modynamischen Eigenschaften verschiedener Aortenklappenprothesen, ins besondere der St. Jude MedicalĂ RegentĂ-Prothese;
2. Intraoperativer Vergleich der Methoden der direkten Druckgradientenbestimmung und der Dopplergradientenbestimmung. Intraoperativ Messung des transvalvulĂ€ren Druckgradienten mittels wassergefĂŒllter Katheter und transösophagealer Echokardiographie, weiterhin Berechnung der KlappenöffnungsflĂ€che nach der Gorlin-Formel und der KontinuitĂ€tsgleichung. Es ergab sich sowohl intra- als auch postoperativ eine tendenzielle Ăberlegenheit der St. Jude MedicalĂ RegentĂ-Prothese gegen ĂŒber den anderen untersuchten Modellen. Die Druckgradienten der beiden Methoden zeigten eine gute Ăbereinstimmung, was fĂŒr die KlappenöffnungsflĂ€chen nicht gezeigt werden konnte. Als Ursache fĂŒr die Ăberlegenheit der St. Jude MedicalĂ RegentĂ-Prothese ist vermutlich der gröĂere Innendurchmesser dieses Modells anzusehen. Die schlechte Ăbereinstimmung der beiden Methoden bei den KlappenöffnungsflĂ€chen erklĂ€rt sich vermutlich dadurch, dass Klappenprothesen kein homogenes Geschwindigkeitsprofil zeigen, welches als Voraussetzung fĂŒr die Berechnung der KontinuitĂ€tsgleichung angesehen werden muss
Safety and Efficiency of Rotational Atherectomy in Chronic Total Coronary Occlusion-One-Year Clinical Outcomes of an Observational Registry.
The study sought to assess the procedural success of rotational atherectomy (RA) in coronary chronic total occlusion (CTO) and to investigate the in-hospital and one-year outcomes following RA. From 2015 to 2019, patients undergoing percutaneous coronary intervention for CTO (CTO PCI) were retrospectively included into the hospital database. The primary endpoint was procedural success. Secondary endpoints were in-hospital and one-year major adverse cardiovascular and cerebral event (MACCE) rates. During the study period of 5 years, 2.789 patients underwent CTO PCI. Patients treated with RA (n = 193, 6.92%) had a significantly higher procedural success (93.26% vs. 85.10%, p = 0.0002) compared to those treated without RA (n = 2.596, 93.08%). Despite a significantly higher rate of pericardiocentesis (3.11% vs. 0.50%, p = 0.0013) in the RA group, the in-hospital and one-year MACCE rate was similar in both groups (4.15% vs. 2.77%, p = 0.2612; 18.65% vs. 16.72%, p = 0.485). In conclusion, RA is associated with higher procedural success for CTO PCI, but has higher risks for pericardial tamponade than CTO PCI without the need for RA. Nevertheless, in-hospital and one-year MACCE rates did not differ in-between both groups
A heart teamâs perspective on interventional mitral valve repair: Percutaneous clip implantation as an important adjunct to a surgical mitral valve program for treatment of high-risk patients
ObjectiveSurgical mitral valve repair carries an elevated perioperative risk in the presence of severely reduced ventricular function and relevant comorbidities. We sought to assess the feasibility of catheter-based mitral valve repair using a clip-based percutaneous edge-to-edge repair system in selected patients at high surgical risk with mitral regurgitation grade 3 or worse.MethodsBetween 2002 and January 2011, 202 consecutive patients without prior mitral valve surgery (age 75 ± 9 years; 63% were male) with symptomatic functional (65%), degenerative (27%), or mixed (8%) mitral regurgitation were treated with a percutaneous clip system for approximation of the anterior and posterior mitral leaflets. Risk for mitral valve surgery was considered high in terms of a mean logistic European System for Cardiac Operative Risk Evaluation of 44% (range, 21%â54%). Preprocedural left ventricular ejection fraction was 35% or less in 36% of patients. An interdisciplinary heart team of cardiologists and cardiac surgeons discussed all patients.ResultsPercutaneous clip implantation was successful in 186 patients (92%). Patients were treated with 1 clip (n = 125; 62%), 2 clips (n = 64; 32%), or 3 or more clips (n = 7; 3%). Reduction in mitral regurgitation from pre- to postprocedure was significant (P < .0001) and remained stable within the first 12 months in the majority of patients. Thirty-day mortality was 3.5% (7/202 patients). Hospital stay was 12 ± 10 days, and median intensive care unit stay was 1 day (range, 0â45 days). Eleven patients required surgical valve repair/replacement at a median of 38 days (0â468 days) after percutaneous clip implantation.ConclusionsClip-based percutaneous mitral valve repair is a safe, low-risk, and effective therapeutic option in symptomatic patients with a high risk for surgery and does not exclude later surgical repair
Bergbaumonitoring im suÌdlichen Ruhrgebiet
Der verantwortungsbewusste Umgang mit alt- und nachbergbaulichen Strukturen umfasst
den Aufbau und die Entwicklung eines integrierten Risikomanagementsystems. Daher ist es wichtig, aktuelle Informationen ĂŒber die bergbaulichen Elemente, ihren Zustand und mögliche Auswirkungen auf die TagesoberflĂ€che mittels verschiedener Monitoringmethoden zu ermitteln. Die Ăberwachung mittels Methoden der satellitengestĂŒtzten Erdbeobachtung generiert Sensordaten, die mit in-situ DatensĂ€tzen zu validieren sind. Im Projekt "Gemeinsames Monitoring im Altbergbau" wurden fĂŒr die Altgesellschaften des
Steinkohlenbergbaus im sĂŒdlichen Ruhrgebiet in einer ersten Projektphase die Elemente des
Alt- und Nachbergbaus, die möglichen Ereignisse und die Parameter zur Detektion und die Möglichkeit der Messung der Ereignisse integriert betrachtet. In der aktuell laufenden zweiten Projektphase werden Radardaten des EU-Copernicus Programmes genutzt, um Bodenbewegungen mittels radarinterferometrischer PSI- und DSI-Methoden zu detektieren. Hierbei kommen innovative Methoden zur frĂŒhzeitigen Integration der OberflĂ€chennutzung zur Anwendung,
um so eine bessere Klassifizierung und Signifikanzanalyse der Bodenbewegung zu
erreichen. Der Auswerteprozess wird zusÀtzlich mit alt- und nachbergbaulichen in-situ Daten
angereichert.
Das Projekt "Gemeinsames Monitoring im Altbergbau" bietet somit zukĂŒnftig die Möglichkeit
alt- und nachbergbauliche Fragestellungen im Rahmen eines integrierten Risikomanagementsystems
zu beantworten
Immunoblot analysis of the seroreactivity to recombinant Borrelia burgdorferi sensu lato antigens, including VlsE, in the long-term course of treated patients with Erythema migrans
Objective: We evaluated whether immunoblotting is capable of substantiating the posttreatment clinical assessment of patients with erythema migrans ( EM), the hallmark of early Lyme borreliosis. Methods: In 50 patients, seroreactivity to different antigens of Borrelia burgdorferi sensu lato was analyzed by a recombinant immunoblot test (IB) in consecutive serum samples from a minimum follow-up period of 1 year. Antigens in the IgG test were decorin- binding protein A, internal fragment of p41 (p41i), outer surface protein C (OspC), p39, variable major protein-like sequence expressed (VlsE), p58 and p100; those in the IgM test were p41i, OspC and p39. Immune responses were correlated with clinical and treatment-related parameters. Results: Positive IB results were found in 50% before, in 57% directly after therapy and in 44% by the end of the follow-up for the IgG class, and in 36, 43 and 12% for the IgM class. In acute and convalescence phase sera, VlsE was most immunogenic on IgG testing 60 and 70%), and p41i (46 and 57%) and OspC (40 and 57%) for the IgM class. By the end of the follow-up, only the anti-p41i lgM response was significantly decreased to 24%. Conclusions: No correlation was found between IB results and treatment-related parameters. Thus, immunoblotting does not add to the clinical assessment of EM patients after treatment. Copyright (c) 2008 S. Karger AG, Basel
Die Burgruine Henneberg in SĂŒdthĂŒringen: Stammburg der Henneberger Grafen ; Text. Teil 1. Text
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