“Alla ricerca del disco perduto”

Raiders of the Lost Record Hereby we will consider in particular the relations between jazz and record experts. The search for “hidden treasures”, such as unpublished live recordings, has brought to the growth of collections of records which are very interesting from a musicological point of view. We will examine various types of collectors, from those who relate to the record as an object, to those who are interested in its “musical message”. The exemplary story of the collector Dick Rieber has inspired the latter. The relation between collector and music producer has always been fruitful prolific and very often the two characters are the same person. Both theoretical and material contributions of collectors to discography are always very interesting. In the end we will examine the situation in Italy and we will show the personal story of the author who contributed to the production of plenty of music brands

Progressive content-based retrieval of image and video with adaptive and iterative refinement

A method and apparatus for minimizing the time required to obtain results for a content based query in a data base. More specifically, with this invention, the data base is partitioned into a plurality of groups. Then, a schedule or sequence of groups is assigned to each of the operations of the query, where the schedule represents the order in which an operation of the query will be applied to the groups in the schedule. Each schedule is arranged so that each application of the operation operates on the group which will yield intermediate results that are closest to final results

Novel Chapter Abstractive Summarization using Spinal Tree Aware Sub-Sentential Content Selection

Summarizing novel chapters is a difficult task due to the input length and the fact that sentences that appear in the desired summaries draw content from multiple places throughout the chapter. We present a pipelined extractive-abstractive approach where the extractive step filters the content that is passed to the abstractive component. Extremely lengthy input also results in a highly skewed dataset towards negative instances for extractive summarization; we thus adopt a margin ranking loss for extraction to encourage separation between positive and negative examples. Our extraction component operates at the constituent level; our approach to this problem enriches the text with spinal tree information which provides syntactic context (in the form of constituents) to the extraction model. We show an improvement of 3.71 Rouge-1 points over best results reported in prior work on an existing novel chapter dataset

Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation

The direct ghrelin (Ghr) involvement in cardiovascular (CV) system homeostasis has been suggested by the expression of its receptor in CV tissues and by evidence that ghrelin mediates CV activities in animals and in humans. Moreover, low Ghr plasma levels have been reported in pathological conditions characterized by high cardiovascular risk. In the present study, we investigated Ghr effect on proliferation of human aortic endothelial cell (HAEC) and involved transduction pathways. Our results indicate that ghrelin elicited proliferation in a dose-dependent manner (EC(50) about of 5 nmol/L) in cultured HAEC, and that this effect was inhibited by the receptor antagonist (D-Lys3)-GHRP-6. Western blot experiments documented an activation of external receptor activated kinases (ERK1/2) and Akt in a dose-dependent fashion, as well as involvement of the cAMP pathway in ERK1/2 phosphorylation. Experiments conducted with appropriate pharmacological inhibitors to investigate Ghr-induced HAEC proliferation confirmed the involvement of ERK1/2 and 13P/Akt pathways, as well as the role of AMP cyclase/PKA pathway in ERK1/2 phosphorylation. Our results indicate that Ghr promotes HAEC proliferation, and thus may be a protective factor against vascular damage. The low ghrelin serum levels reported in insulin-resistant states may not be able to effectively counteract endothelial cell injury. (C) 2008 Elsevier Inc. All rights reserved

Multidimensional indexing structure for use with linear optimization queries

Linear optimization queries, which usually arise in various decision support and resource planning applications, are queries that retrieve top N data records (where N is an integer greater than zero) which satisfy a specific optimization criterion. The optimization criterion is to either maximize or minimize a linear equation. The coefficients of the linear equation are given at query time. Methods and apparatus are disclosed for constructing, maintaining and utilizing a multidimensional indexing structure of database records to improve the execution speed of linear optimization queries. Database records with numerical attributes are organized into a number of layers and each layer represents a geometric structure called convex hull. Such linear optimization queries are processed by searching from the outer-most layer of this multi-layer indexing structure inwards. At least one record per layer will satisfy the query criterion and the number of layers needed to be searched depends on the spatial distribution of records, the query-issued linear coefficients, and N, the number of records to be returned. When N is small compared to the total size of the database, answering the query typically requires searching only a small fraction of all relevant records, resulting in a tremendous speedup as compared to linearly scanning the entire dataset

Effects of NSAIDs and paracetamol (acetaminophen) on protein kinase C epsilon translocation and on substance P synthesis and release in cultured sensory neurons.

Celecoxib, diclofenac, ibuprofen, and nimesulide are nonsteroidal anti-inflammatory drugs (NSAIDs) very commonly used for the treatment of moderate to mild pain, together with paracetamol (acetaminophen), a very widely used analgesic with a lesser anti-inflammatory effect. In the study reported here, we tested the efficacy of celecoxib, diclofenac, and ibuprofen on preprotachykinin mRNA synthesis, substance P (SP) release, prostaglandin E(2) (PGE(2)) release, and protein kinase C epsilon (PKC\u25b) translocation in rat cultured sensory neurons from dorsal root ganglia (DRGs). The efficacy of these NSAIDs was compared with the efficacy of paracetamol and nimesulide in in vitro models of hyperalgesia (investigated previously). While nimesulide and paracetamol, as in previous experiments, decreased the percentage of cultured DRG neurons showing translocation of PKC\u25b caused by 100 nM thrombin or 1 \u3bcM bradykinin in a dose-dependent manner, the other NSAIDs tested did not have a significant effect. The amount of SP released by peptidergic neurons and the expression level of preprotachykinin mRNA were assessed in basal conditions and after 70 minutes or 36 hours of stimulation with an inflammatory soup (IS) containing potassium chloride, thrombin, bradykinin, and endothelin-1. The release of SP at 70 minutes was inhibited only by nimesulide, while celecoxib and diclofenac were effective at 36 hours. The mRNA basal level of the SP precursor preprotachykinin expressed in DRG neurons was reduced only by nimesulide, while the increased levels expressed during treatment with the IS were significantly reduced by all drugs tested, with the exception of ibuprofen. All drugs were able to decrease basal and IS-stimulated PGE(2) release. Our study demonstrates novel mechanisms of action of commonly used NSAIDS

Methods and apparatus for extraction and tracking of objects from multi-dimensional sequence data

An object tracking technique is provided which, given: (i) a potentially large data set; (ii) a set of dimensions along which the data has been ordered; and (iii) a set of functions for measuring the similarity between data elements, a set of objects are produced. Each of these objects is defined by a list of data elements. Each of the data elements on this list contains the probability that the data element is part of the object. The method produces these lists via an adaptive, knowledge-based search function which directs the search for high-probability data elements. This serves to reduce the number of data element combinations evaluated while preserving the most flexibility in defining the associations of data elements which comprise an object

Pre-training Intent-Aware Encoders for Zero- and Few-Shot Intent Classification

Intent classification (IC) plays an important role in task-oriented dialogue systems as it identifies user intents from given utterances. However, models trained on limited annotations for IC often suffer from a lack of generalization to unseen intent classes. We propose a novel pre-training method for text encoders that uses contrastive learning with intent psuedo-labels to produce embeddings that are well-suited for IC tasks. By applying this pre-training strategy, we also introduce the pre-trained intent-aware encoder (PIE). Specifically, we first train a tagger to identify key phrases within utterances that are crucial for interpreting intents. We then use these extracted phrases to create examples for pre-training a text encoder in a contrastive manner. As a result, our PIE model achieves up to 5.4% and 4.0% higher accuracy than the previous state-of-the-art pre-trained sentence encoder for the N-way zero- and one-shot settings on four IC datasets

Studio preliminare sulla struttura genetica di <i>Patella ferruginea</i> Gmelin, 1791 (Mollusca, Gastropoda), nell'Area Marina Protetta (AMP) dell'Isola dell'Asinara mediante ISSR

L'istituzione delle AMP consente adeguate misure di conservazione dell'ambiente marino. L'efficacia di tale protezione dovrebbe essere verificata attraverso programmi di monitoraggio, utilizzando specie che siano facili da identificare e analizzare in modo non distruttivo. In tale contesto è stata individuata Patella ferruginea, che risulta essere l'invertebrato marino più minacciato del Mediterraneo occidentale. L'obiettivo dello studio è quello di stimare i livelli di diversità genetica e flusso genico di alcune popolazioni di P. ferruginea dell'AMP dell'Isola dell'Asinara. È stato prelevato il materiale biologico di 10 esemplari da 3 diversi siti, tramite escissione di piccole quantità di tessuto muscolare, seguendo un protocollo da noi sperimentato sulla specie P. ulyssiponensis. Il protocollo assicura la sopravvivenza degli esemplari campionati. L'analisi genetica è stata condotta attraverso la genotipizzazione di un subcampione di individui per ciascun sito utilizzando la tecnica ISSR (Inter-Simple Sequence Repeat). I risultati indicano una notevole uniformità genetica tra gli individui appartenenti a ciascun sito, contrapposta ad una moderata eterogeneità genetica tra gli individui appartenenti ai tre siti. Questi fatti suggeriscono inoltre che P. ferruginea possa aver subito erosione genetica negli anni passati in relazione alla sua raccolta, e che i livelli di flusso genico non siano elevati anche su piccola scala geografica