1,524 research outputs found
Nasal pathologies in patients with obstructive sleep apnoea
Nasal obstruction is a frequent condition in patients with obstructive sleep apnoea (OSA). Nasal obstruction leads to mouth breathing, which
is thought to destabilise the upper airway to aggravate the condition. Three conditions could be considered as the cause of the nasal breathing
obstruction: anatomical conditions of the nose (septum deviation, hypertrophy of the inferior turbinates), chronic rhinosinusitis (CRS) and
chronic nasal inflammation caused by allergic rhinitis or non-allergic cellular rhinitis. In this prospective study, we present an evaluation of
all these possible rhino-sinusal aspects in OSA patients to correlate different nasal pathologies with nasal obstruction. Fifty patients with a
diagnosis of OSA were enrolled in the study. In 70% of OSA patients, nasal obstruction was confirmed by clinical evaluation and rhinomanometry testing. Normal rhino-sinus aspects were present in only 20% of OSAS patients, whereas one or more pathological rhino-sinus
conditions were present in the remaining 80%. The percentage of OSA patients with a diagnosis of allergic rhinitis and non-allergic rhinitis
was 18% and 26% respectively. Non-allergic rhinitis with neutrophils (NARNE) was the most frequent type of cellular rhinitis diagnosed
in OSA patients (20% of cases). The results of the present study support and extend the observation that rhinitis is present in OSA patients.
Mucosal inflammation caused by these conditions could be the cause of upper airway patency impairment inducing nasal mucosa swellin
Precision electroweak calculation of the charged current Drell-Yan process
We present a detailed study of the charged current Drell-Yan process, which includes the exact O(alpha) electroweak corrections properly matched with leading-log effects due to multiple-photon emission, as required by the experiments at the Tevatron and the LHC. Numerical results for the relevant observables of single W boson production at hadron colliders are presented. The impact of the radiative corrections and of some sources of theoretical uncertainty is discussed in detail. The calculation has been implemented in the new version of the event generator HORACE, which is available for precision simulations of the charged current Drell-Yan process
Electroweak corrections to the charged current Drell-Yan process
A concise review about the status of the calculation of radiative corrections to the Drell-Yan processes is presented. The effect of matching together exact electroweak O(alpha) corrections with higher-order QED effects due to multiple photon emission is displayed in some physical distributions in the charged current channel, which have obtained with the new version of the event generator HORACE
The natural evolution of endoscopic approaches in skull base surgery: robotic-assisted surgery?
The current surgical trend is to expand the variety of minimally invasive approaches and, in particular, the possible applications of robotic systems in head and neck surgery. This is particularly intriguing in skull base regions. In this paper, we review the current literature and propose personal considerations on the role of robotic techniques in this field. A brief description of our personal preclinical experience on skull base robotic dissection represents the basis for further considerations. We are convinced that the advantages of robotic surgery applied to the posterior cranial fossa are similar to those already clinically experienced in other areas (oropharynx, tongue base), in terms of tremor-free, bimanual, precise dissection: the implementation of instruments for bony work and resolving current drawbacks will definitely increase the applicability of such a system in forthcoming years
Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells
Testosterone by promoting different metabolic pathways contributes to short-term homeostasis of skeletal muscle, the largest insulin-sensitive tissue and the primary site for insulin-stimulated glucose utilization. Despite evidences indicate a close relationship between testosterone and glucose metabolism, the molecular mechanisms responsible for a possible testosterone-mediated insulin-like effects on skeletal muscle are still unknown
Swept source optical coherence tomography findings in a severe traumatic maculopathy following firework ocular injury
A screening mechanism for extra W and Z gauge bosons
We generalize a previous construction of a fermiophobic model to the case of
more than one extra and gauge bosons. We focus in particular on the
existence of screening configurations and their implication on the gauge boson
mass spectrum. One of these configurations allows for the existence of a set of
relatively light new gauge bosons, without violation of the quite restrictive
bounds coming from the parameter. The links with Bess and
degenerate Bess models are also discussed. Also the signal given here by this
more traditional gauge extension of the SM could help to disentangle it from
the towers of Kaluza-Klein states over and gauge bosons in extra
dimensions.Comment: 23 pages, 1 figure, extended discussion on precision tests. To appear
in International Journal of Modern Physics
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Translation of Anticancer Efficacy From Nonclinical Models to the Clinic
Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing human cancer pathophysiology and end with challenges in generating robust translatable preclinical end points. A comprehensive approach that considers clinically relevant mouse models with both an integrated biomarker strategy and a complementary modeling and simulation effort will strengthen the current oncology drug development paradigm
Noncommutative Electrodynamics
In this paper we define a causal Lorentz covariant noncommutative (NC)
classical Electrodynamics. We obtain an explicit realization of the NC theory
by solving perturbatively the Seiberg-Witten map. The action is polynomial in
the field strenght , allowing to preserve both causality and Lorentz
covariance. The general structure of the Lagrangian is studied, to all orders
in the perturbative expansion in the NC parameter . We show that
monochromatic plane waves are solutions of the equations of motion to all
orders. An iterative method has been developed to solve the equations of motion
and has been applied to the study of the corrections to the superposition law
and to the Coulomb law.Comment: 13 pages, 2 figures, one reference adde
Risk factors for obstructive sleep apnea syndrome in children: state of the art
The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS). Although the etiopathogenesis of adult OSAS is well known, many aspects of this syndrome in children are still debated. Its prevalence is about 2% in children from 2 to 8 years of age, mostly related to the size of the upper airways adenoid tissue. Several risk factors linked to the development of OSAS are typical of the pediatric age. The object of this paper is to analyze the state of the art on this specific topic, discussing its implications in terms of diagnosis and management
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