IMMEDIATE RESTORATION CUSTOM-MADE BY ADDITIVE MANUFACTURING ABOUT DENTAL IMPLANTS: PREDICTABLE RESULTS FOR PINK AND WHITE ESTHETICS

The definition of dental implant failure has evolved from focusing solely on lack of osseointegration to encompass broader concerns such as aesthetics. However, the criteria for aesthetic failure in implant dentistry are not well defined. Although several aesthetic indices have been validated to objectively evaluate clinical outcomes, including failure of an implant-supported crown. In this sense, aesthetic flaws in implant dentistry can be categorized into pink and white tissue flaws. This study aims to describe an extensive rehabilitation protocol where implants were placed using printed surgical guides and adaptations for bone and tissue grafts, facilitating restoration in the aesthetic zone. Key clinical stages and aspects are illustrated through the case of a fractured upper left central incisor, where an implant system was used for immediate patient rehabilitation. By highlighting these crucial steps and considerations, this study underscores the effectiveness of immediate implantation and restoration techniques in achieving optimal aesthetic and functional outcomes in dental rehabilitationThe definition of dental implant failure has evolved from focusing solely on lack of osseointegration to encompass broader concerns such as aesthetics. However, the criteria for aesthetic failure in implant dentistry are not well defined. Although several aesthetic indices have been validated to objectively evaluate clinical outcomes, including failure of an implant-supported crown. In this sense, aesthetic flaws in implant dentistry can be categorized into pink and white tissue flaws. This study aims to describe an extensive rehabilitation protocol where implants were placed using printed surgical guides and adaptations for bone and tissue grafts, facilitating restoration in the aesthetic zone. Key clinical stages and aspects are illustrated through the case of a fractured upper left central incisor, where an implant system was used for immediate patient rehabilitation. By highlighting these crucial steps and considerations, this study underscores the effectiveness of immediate implantation and restoration techniques in achieving optimal aesthetic and functional outcomes in dental rehabilitatio

Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L‐DOPA in a mouse model of Parkinson's disease

Background and Purpose: L-DOPA-induced dyskinesia (LID) remains a major complication of L-DOPA therapy in Parkinson's disease. LID is believed to result from inhibition of substantia nigra reticulata (SNr) neurons by GABAergic striatal projection neurons that become supersensitive to dopamine receptor stimulation after severe nigrostriatal degeneration. Here, we asked if stimulation of direct medium spiny neuron (dMSN) GABAergic terminals at the SNr can produce a full dyskinetic state similar to that induced by L-DOPA. Experimental Approach: Adult C57BL6 mice were lesioned with 6-hydroxydopamine in the medial forebrain bundle. Channel rhodopsin was expressed in striatonigral terminals by ipsilateral striatal injection of adeno-associated viral particles under the CaMKII promoter. Optic fibres were implanted on the ipsilateral SNr. Optical stimulation was performed before and 24 hr after three daily doses of L-DOPA at subthreshold and suprathreshold dyskinetic doses. We also examined the combined effect of light stimulation and an acute L-DOPA challenge. Key Results: Optostimulation of striatonigral terminals inhibited SNr neurons and induced all dyskinesia subtypes (optostimulation-induced dyskinesia [OID]) in 6-hydroxydopamine animals, but not in sham-lesioned animals. Additionally, chronic L-DOPA administration sensitised dyskinetic responses to striatonigral terminal optostimulation, as OIDs were more severe 24 hr after L-DOPA administration. Furthermore, L-DOPA combined with light stimulation did not result in higher dyskinesia scores than OID alone, suggesting that optostimulation has a masking effect on LID. Conclusion and Implications: This work suggests that striatonigral inhibition of basal ganglia output (SNr) is a decisive mechanism mediating LID and identifies the SNr as a target for managing LID.Fil: Keifman, Ettel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Consejo Superior de Investigaciones Científicas; EspañaFil: Ruiz De Diego, Irene. Consejo Superior de Investigaciones Científicas; EspañaFil: Pafundo, Diego Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Paz, Rodrigo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Solís, Oscar. Consejo Superior de Investigaciones Científicas; EspañaFil: Murer, Mario Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Moratalla, Rosario. Consejo Superior de Investigaciones Científicas; Españ

STEP-BY-STEP SYSTEM FOR DENTAL CERAMIC AESTHETIC REHABILITATION OF ANTERIOR TEETH

Stratification in dental ceramics is an essential technique for creating aesthetic and functional dental restorations that accurately mimic the appearance and properties of natural teeth. It requires a deep understanding of the materials used and technical skills to ensure high-quality results. This study aims to describe an extensive rehabilitation protocol, through a short communication, the step-by-step process of the stratification technique. The goal is to explore the different techniques for fabricating ceramic restorations, with a special focus on the stratification technique, reviewing its processing methods and highlighting the advantages and challenges associated with this approach.Stratification in dental ceramics is an essential technique for creating aesthetic and functional dental restorations that accurately mimic the appearance and properties of natural teeth. It requires a deep understanding of the materials used and technical skills to ensure high-quality results. This study aims to describe an extensive rehabilitation protocol, through a short communication, the step-by-step process of the stratification technique. The goal is to explore the different techniques for fabricating ceramic restorations, with a special focus on the stratification technique, reviewing its processing methods and highlighting the advantages and challenges associated with this approach

Modelling of electrical power demand characteristics for composite machine shopps

none2Stochastic models of both the active and reactive electrical power demand of composite industrial plants are obtained from a detailed analysis of the use of individual pieces of equipment. Since the reactive load patterns differ significantly from the active ones, two distinct models should be identified. The load-duration curves are then determined and, in particular, the probability distributions of maximum 15 min average demands are derived. In this way, energy consumption, peak power demand and the optimal power factor correction may be found. The methodology has been successfully applied to the study of a machine-shop comprising more than 200 machines.noneR. Caldon;U. ViaroCaldon, Roberto; U., Viar

Simulazione del carico elettrico di utenze industriali

Viene illustrato un metodo probabilistico per la stima delle ca\uacratteristiche delle richieste di potenza elettrica di utenze industriali con carico ripartito su pi\uf9 macchine. Si mostra come il metodo possa essere im\uacpiegato per valutare i costi dell'energia elettrica corrispondenti a regimi alternativi di utilizzo delle apparecchiature ed in particolare ottenere le indicazioni necessarie al contenimento dei picchi di potenza nelle fasce orarie di punta ed alla migliore correzione del fattore di potenza. Vengono indicati i risultati ottenuti dall'applicazione del metodo ad un impianto in esercizio

Previsione delle curve di massimo carico del sistema elettrico italiano in rapporto ai grandi settori di utenza

La carretta programmazione di nuovi impianti di generazione e di accumula e la determinazione della riserva su cui fare assegnamento rendano di par ticolare importanza l'analisi e la previsione delle curve di carico nei giorni di punta massima annuale, che presentano generalmente anche la maggia re escursione fra i valori massimo e minimo della domanda di potenza. Per individuare possibili effetti di variazioni della struttura tariffaria è inaltre opportuno che tale previsione consideri pure i contributi delle principali categorie di utenza (industria e settori domestico e terziario) alla formazione della pò tenza totale richiesta

Suppression of activity in the forelimb motor cortex temporarily enlarges forelimb representation in the homotopic cortex in adult rats.

After forelimb motor cortex (FMC) damage, the unaffected homotopic motor cortex showed plastic changes. The present experiments were designed to clarify the electrophysiological nature of these interhemispheric effects. To this end the output reorganization of the forelimb motor cortex (FMC) was investigated after homotopic area activity was suppressed in adult rats. FMC output was compared after Lidocaine-induced inactivation (L group) or Quinolinic acid-induced lesion (Q-group) of the contralateral homotopic cortex. In the Q-group of animals, FMC mapping was performed, respectively, three days (Q3D group) and two weeks (Q2W group) after cortical lesion. In each animal, FMC output was assessed by mapping movements induced by intracortical microstimulation (ICMS) in both hemispheres (hemisphere Ipsilateral and Contralateral to injections). Findings demonstrated that in the L-group, the size of forelimb representation was 42.2% higher than in the Control group (P<0.0001). The percentage of dual forelimb-vibrissa movement sites significantly increased over the Controls (P<0.0005). The dual-movement sites occupied a strip of the map along the rostro-caudal border between the forelimb and vibrissa representation. This form of interhemispheric diaschisis had completely reversed, with the recovery of the baseline map, 3 days after the lesion in the contalatreral FMC. This restored forelimb map showed no ICMS-induced changes 2 weeks after the lesion in the contralateral FMC. The present results suggest that the FMCs in the two hemispheres interact continuously through predominantly inhibitory influences that preserve the forelimb representation and the border vs. vibrissa representation