Marine sponge and octocoral-associated bacteria show versatile secondary metabolite biosynthesis potential and antimicrobial activities against human pathogens

Marine microbiomes are prolific sources of bioactive natural products of potential pharmaceutical value. This study inspected two culture collections comprising 919 host-associated marine bacteria belonging to 55 genera and several thus-far unclassified lineages to identify isolates with potentially rich secondary metabolism and antimicrobial activities. Seventy representative isolates had their genomes mined for secondary metabolite biosynthetic gene clusters (SM-BGCs) and were screened for antimicrobial activities against four pathogenic bacteria and five pathogenic Candida strains. In total, 466 SM-BGCs were identified, with antimicrobial peptide- and polyketide synthase-related SM-BGCs being frequently detected. Only 38 SM-BGCs had similarities greater than 70% to SM-BGCs encoding known compounds, highlighting the potential biosynthetic novelty encoded by these genomes. Cross-streak assays showed that 33 of the 70 genome-sequenced isolates were active against at least one Candida species, while 44 isolates showed activity against at least one bacterial pathogen. Taxon-specific differences in antimicrobial activity among isolates suggested distinct molecules involved in antagonism against bacterial versus Candida pathogens. The here reported culture collections and genome-sequenced isolates constitute a valuable resource of understudied marine bacteria displaying antimicrobial activities and potential for the biosynthesis of novel secondary metabolites, holding promise for a future sustainable production of marine drug leads.info:eu-repo/semantics/publishedVersio

Telessaúde Covid: caracterização sociodemográfica, clínico-epidemiológica e indicadores do telemonitoramento em Viçosa-MG

Em 2020, a Universidade Federal de Viçosa e a Gestão Municipal implementaram o projeto de extensão Telessaúde Covid para o enfrentamento da pandemia. O objetivo é fazer uma análise descritiva dos quatorze meses de atuação do projeto. Realizou-se análise descritiva da caracterização sociodemográfica, clínico-epidemiológica e indicadores do serviço. Foram atendidos 6.898 pacientes, predominando o gênero feminino e adultos jovens. Os sinais e sintomas mais frequentes foram cefaleia, tosse, coriza, dor de garganta, dor muscular e febre. O RT-PCR foi o teste realizado pela maioria e 31,6% dos pacientes foram positivos. O serviço concluiu o encerramento de 91,5% dos atendimentos. O Telessaúde Covid foi relevante para o contingenciamento da Covid-19, com número expressivo de atendimentos, e contemplou a missão social da universidade pública, transformando o modelo assistencial e reorientando o processo de formação e ação profissional de estudantes e profissionais de saúde