Complete nucleotide sequence of a potato isolate of strain group C of Potato virus Y from 1938

The complete genomic sequence of an isolate (PRI-509) of the C strain of Potato virus Y (PVYC), which was originally isolated from potato in 1938, was elucidated. The genomic RNA of PRI-509 consists of 9699 nucleotides, with the capacity to encode a polyprotein of 3061 amino acids with a molecular mass of 337 kDa

Tomato chocolàte virus: a new plant virus infecting tomato and a proposed member of the genus Torradovirus

A new virus was isolated from a tomato plant from Guatemala showing necrotic spots on the bases of the leaves and chocolate-brown patches on the fruits. Structural and molecular analysis showed the virus to be clearly related to but distinct from the recently described Tomato torrado virus (ToTV) and Tomato marchitez virus (ToMarV), both members of the genus Torradovirus. The name tomato chocolàte virus is proposed for this new torradovirus

CO2 and non-CO2 balanced environmental scores module for flight performance evaluation and optimisation

The SESAR2020 exploratory research (ER4) programme CREATE (Grant 890898) developed a climate and weather aware Concept of Operations (ConOps) which encompasses a multi-aircraft 4D trajectory optimisation framework, which utilises a CO2 and non-CO2 balanced Environmental Scores Module (ESM) for the en-route flight phase. The ESM provides a computational method to evaluate the “greenness” of aircraft trajectories. Some components related to the internal ESM scoring are based on expert judgement, which is in line with the technology readiness level (TRL) 1 of the solution. Fast-time simulations were performed to demonstrate the proof-of-concept of the ESM in a multi-aircraft tactical optimisation scenario in the North-Atlantic region. The results show that, because of the simplicity of the metric, the ESM could be well used for trajectory optimisation and tactical replanning, and most likely as well as flight and ATC sector environmental performance evaluations.The work presented in this paper has received funding from the SESAR Joint Undertaking (JU) under grant agreement No 890898, corresponding to the project “Innovative Operations and Climate and Weather Models to Improve ATM Resilience and Reduce Impacts” (SESAR-H2020-ER4 CREATE) within the European Union's Horizon 2020 research and innovation program.Peer ReviewedPostprint (published version

Alternative 4D trajectories for the avoidance of weather- and contrail-sensitive volumes

We present a framework to generate, in a multi-aircraft environment, 4D optimized trajectories in a scenario with several weather constraints obtained with advanced weather prediction models. We focus on the trajectory optimization module of this framework, which is based on a point-mass representation of the aircraft. By tuning some of the parameters of this module, we compute several alternative trajectories avoiding these constraints both laterally and vertically. The experiment conducted involves flights crossing the North Atlantic region, while in the en-route phase. This preliminary framework is also used to run the experiments in multiple cycles or consecutive time periods, assuming different update times for the weather constraints, and choosing the best trajectory per flight and per cycle. The ultimate goal of the framework is to develop innovative procedures in the air traffic management system to reduce the climate and environmental impact of aviation, while increasing the resilience of air operations to weather phenomena.Peer ReviewedPostprint (published version

A clinical decision aid to discern patients without and with midfacial and mandibular fractures that require treatment (the REDUCTION-II study):a prospective multicentre cohort study

Purpose: To assess the diagnostic accuracy of physical examination findings and to construct clinical decision aids to discern emergency department patients without and with midfacial and mandibular fractures that require treatment. Methods: A prospective multicentre cohort study was conducted in four hospitals in the Netherlands. Consecutive maxillofacial trauma patients were included whereupon each patient underwent a standardized physical examination consisting of 15 and 14 findings for midfacial and mandibular trauma, respectively. The primary outcome was the decision whether to treat during the emergency department stay or within 24 h of admission. The diagnostic accuracy was calculated for the individual physical examination findings and ensuing clinical decision aids with the focus being on detecting midfacial and mandibular fractures that require active treatment. Results: A total of 766 midfacial trauma patients were identified of whom 339 (44.3%) had midfacial fractures. Of those, 74 (21.8%) required active treatment. A total of 280 mandibular trauma patients were identified of whom 66 (23.6%) had mandibular fractures. Of those, 37 (56.0%) required active treatment. The decision aid for midfacial trauma consisting of facial depression, epistaxis, ocular movement limitation, palpable step-off, objective malocclusion and tooth mobility or avulsion had a sensitivity of 97.3 (90.7–99.3), a specificity of 38.6 (35.0–42.3), and a negative predictive value of 99.3 (97.3–99.8). The decision aid for mandibular trauma consisting of mouth opening limitation, jaw movement pain, objective malocclusion and tooth mobility or avulsion resulted in a sensitivity of 100.0 (90.6–100.0), a specificity of 39.1 (33.2–45.4), and a negative predictive value of 100.0 (96.1–100.0). Conclusion: The clinical decision aids successfully identified midfacial and mandibular trauma patients requiring active fracture treatment and so may be useful in preventing unnecessary radiological procedures in the future. Trial Registration: The study was registered at ClinicalTrials.gov with the identifier NCT03314480

A “Calvinist” Theory of Matter? Burgersdijk and Descartes on res extensa

In the Dutch debates on Cartesianism of the 1640s, a minority believed that some Cartesian views were in fact Calvinist ones. The paper argues that, among others, a likely precursor of this position is the Aristotelian Franco Burgersdijk (1590-1635), who held a reductionist view of accidents and of the essential extension of matter on Calvinist grounds. It seems unlikely that Descartes was unaware of these views. The claim is that Descartes had two aims in his Replies to Arnauld: to show the compatibility of res extensa and the Catholic transubstantiation but also to differentiate the res extensa from some views of matter explicitly defended by some Calvinists. The association with Calvinism will be eventually used polemically against Cartesianism, for example in France. The paper finally suggests that, notwithstanding the points of conflict, the affinities between the theologically relevant theories of accidents, matter and extension ultimately facilitated the dissemination of Cartesianism among the Calvinists

No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial

Contains fulltext : 71117.pdf (publisher's version ) (Open Access)BACKGROUND: The objective of this study was to determine whether treatment with the nonselective nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows cognitive decline in patients with Alzheimer's disease (AD). METHODOLOGY/PRINCIPAL FINDINGS: This double-blind, randomized, placebo-controlled trial was conducted between May 2000 and September 2005 in two hospitals in the Netherlands. 51 patients with mild to moderate AD were enrolled into the study. Patients received 100 mg indomethacin or placebo daily for 12 months. Additionally, all patients received omeprazole. The primary outcome measure was the change from baseline after one year of treatment on the cognitive subscale of the AD Assessment Scale (ADAS-cog). Secondary outcome measures included the Mini-Mental State Examination, the Clinician's Interview Based Impression of Change with caregiver input, the noncognitive subscale of the ADAS, the Neuropsychiatric Inventory, and the Interview for Deterioration in Daily life in Dementia. Considerable recruitment problems of participants were encountered, leading to an underpowered study. In the placebo group, 19 out of 25 patients completed the study, and 19 out of 26 patients in the indomethacin group. The deterioration on the ADAS-cog was less in the indomethacin group (7.8+/-7.6), than in the placebo group (9.3+/-10.0). This difference (1.5 points; CI -4.5-7.5) was not statistically significant, and neither were any of the secondary outcome measures. CONCLUSIONS/SIGNIFICANCE: The results of this study are inconclusive with respect to the hypothesis that indomethacin slows the progression of AD

Transition Guidelines for A-SMGCS

These Transition Guidelines for Advanced Surface Movement Guidance and Control System (A SMGCS) are intended for use by the stakeholders: airport, ANSP (Air Navigation Service Provider), airline, and industry. The guidelines give an overview of the main STEPS, but not necessarily all steps, for the introduction of and transition to A SMGCS operations at an airport. They address the technical, operational, administrative, training and licensing aspects. The guidelines are no international standard that needs to be obeyed for certification on an A SMGCS, but represents an overview of steps that are considered appropriate by the EMMA consortium. It recognises that alternative means may be available