Synthesis of novel ⍺-arylpropionic acids and their derivatives

1343-1346A series of 2-(6H-benzo[c]chromen-3-yl)propionic acids have been synthesized and evaluated for COX-2 inhibitor activity

Total synthesis of lasofoxifene and nafoxidine

<p>An intramolecular reductive coupling process of diketone with low-valent titanium species to form a dihydronapthalene skeleton was an important step in the synthesis of nafoxidine (<b>1</b>) and lasofoxifene (<b>2</b>). Diketone <b>6</b> was prepared in a convenient, three-step sequence starting from 3-methoxy benzaldehyde in good yields.</p

Novel acid catalysed rearrangement of duloxetine

1695-1698A novel acid catalysed rearrangement of aryl methyl ethers (duloxetine) to diaryl methanes is described

Thermal rearrangement of tert-butylsulfinamide

tert-Butylsulfinamides are unstable above room temperature, and in chlorinated solvents they undergo rearrangement to form the more stable N-(tert-butylthio)-tert-butylsulfonamide

Total Synthesis of an Experimental Antitubercular Drug CDRI-830

<div><p></p><p>The triarylmethane antituberculosis drug CDRI-830 is synthesized. The triarylmethane derivative <b>4</b> is prepared from ether <b>6</b> by a rearrangement process. The total synthesis of the drug CDRI-830 is achieved in a good overall yield of 35% from a simple thiophene derivative <b>8</b>.</p> </div

New Synthesis of (±)-Cherylline and Mono- and Dimethyl Ethers

<div><p></p><p>The synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines is achieved via the ether rearrangement methodology. Subsequent reactions yielded cherylline and ether derivatives of amaryllidaceac alkaloids.</p> </div

Syntheses of 4-Aryl Chromanes: A Rearrangement Approach

<div><p></p><p>4-Aryl chromanes are synthesized from 4-Aryloxy chromanes via a rearrangement methodology.</p></div