Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release

Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications

Nanogels, or nanostructured hydrogels, are one of the most interesting materials in biomedical engineering. Nanogels are widely used in medical applications, such as in cancer therapy, targeted delivery of proteins, genes and DNAs, and scaffolds in tissue regeneration. One salient feature of nanogels is their tunable responsiveness to external stimuli. In this review, thermosensitive nanogels are discussed, with a focus on moieties in their chemical structure which are responsible for thermosensitivity. These thermosensitive moieties can be classified into four groups, namely, polymers bearing amide groups, ether groups, vinyl ether groups and hydrophilic polymers bearing hydrophobic groups. These novel thermoresponsive nanogels provide effective drug delivery systems and tissue regeneration constructs for treating patients in many clinical applications, such as targeted, sustained and controlled release

Novel Scoring System for Prediction of Cardiac Syndrome X in Women with Typical Angina and a Positive Exercise Tolerance Test

A major diagnostic challenge for cardiologists is to distinguish cardiac syndrome X (CSX) from obstructive coronary artery disease in women with typical angina and a positive exercise tolerance test (ETT). We performed this study to develop a scoring system that more accurately predicts CSX in this patient population. Data on 976 women with typical angina and a positive ETT who underwent coronary angiography at our center were randomly divided into derivation and validation datasets. We developed a backward stepwise logistic regression model that predicted the presence of CSX, and a scoring system was derived from it. The derivation dataset (809 patients) was calibrated by uing a Hosmer-Lemeshow goodness-of-fit test (8 degrees of freedom; χ2=12.9; P=0.115), and the area under the curve was 0.758. The validation dataset (167 patients) was calibrated in the same way (8 degrees of freedom; χ2=9.0; P=0.339), and the area under the curve was 0.782. Independent predictors of CSX were age \u3c55 years; negative histories of smoking, diabetes mellitus, hyperlipidemia, hypertension, or familial premature coronary artery disease; and highly positive ETTs. A total score \u3e9.5 was the optimal cutoff point for differentiating CSX from obstructive coronary artery disease. Our proposed scoring system is a simple, objective, and accurate system for distinguishing CSX from obstructive coronary artery disease in women with typical angina and positive ETTs. It may help determine which of these patients need invasive coronary angiograms or noninvasive tests like computed tomographic coronary angiography

A Comparative Study of Reflections of Resistance in the Poetry of Malek-o-Shoara Bahar and Amal Donqol

Resistance literature is usually created in the conditions of oppression, inner despotism, lack of social and individual freedom, defiance of law, and foreign aggression. Since the old times to the period of Constitutionalism in Iran, and the contemporary Arab Movement, Iran and Egypt have produced valuable works in resistance literature due to their outstanding resistance to indoor injustice, foreign aggression and cultural attacks. In Iran, resistance literature has a flourishing in Constitutionalism era, and poets like Mirzadeh Eshghi, Seyed Ashrafodin Gilani, Aref Ghazvini, Farokhi Yazdi, and Bahar are the most active in this field; as for the contemporary Egyptian-Arabic Movement, poets like Hafez Ebrahim, Marouf Al-Rassafi, Mohammad Mahdi Al-Javaheri, Mahmoud Darvish, Ebrahim Toqan, and Amal Donqol are among the celebrated ones. Malek-o-Shoara Bahar and Amal Donqol are political and liberal elite poets of Iran and Egypt who fought culturally against autarchy and colonizers. Based on the American school of comparative criticism, this study tries to illustrate resistance literature during Constitutionalism era in Iran, and the era of the Arab Movement

Preparation of Chitosan Nanoparticles Loaded by Dexamethasone Sodium Phosphate: Chitosan nanoparticles loaded by dexamethasone

Biodegradable nanoparticulate carriers, have important potential applications for administration of therapeutic molecules. Chitosan based nanoparticles have attracted a lot of attention upon their biological properties such as biodegradability, biocom-patibility and bioadhesivity. The aim of the present investigation was to describe the synthesis and characterization of novel biodegradable nanoparticles based on chitosan for encapsulation of dexamethasone sodium phosphate. To achieve this objective, ionic gelation method were used. Drug containing nanoparticles were prepared with different amounts of drug. The mean size and size distribution of nanoparticles were measured by dynamic laser light scattering. The mean particle size, varied in the range of 250-350 nm. Values of loading capacity and loading efficiency varied between 33.7%-72.2% and 44.5%-76.0% for prepared nanoparticles