IN VITRO AND IN VIVO REMOVAL OF ORAL ANTIDIABETIC AGENTS (METFORMIN) USING ACTIVATED CARBONS

Diabetes is the most worldwide common chronic disease, according the International Diabetes Federation [1], more than 32 million citizens living in the European Union have diabetes, representing nearly 10% of the population, to which we should add equal number of people suffering from impaired glucose tolerance. Diabetes prevalence is growing at alarming rate worldwide, being of particular relevance the type 2 diabetes. Nowadays 285 million people worldwide live with diabetes and it is expected that this numbers will increase by 20% until 2030 due to obesity and the ageing of the population [1]. This growth leads to an increasing consumption of drugs such as oral antidiabetics. Metformin is one of the active principles most commonly used for this purpose being among the pharmaceuticals with the highest production numbers worldwide to treat type 2 diabetes because is cheap, has high level of tolerance and when used in the prescribed dosage is very secure with minimal side effects. However, in case of overdose of metformin upon a ingestion of more than 10 times the prescribed dosage, accidentally or on propose, lactic acidosis and low blood pressure can occur. Overdoses with metformin are relatively uncommon, but may have serious consequences, if medical attention is not given on time, it may lead to coma and ultimately death Because of its spread use another problem must be taken into consideration, which needs to be addressed, the occurrence of metformin residues in sewage and surface waters due to improper discharge of the non-used tablets to regular garbage [2]. This situation is becoming a serious problem of environmental pollution and public health. This paper reports the use of activated carbon produced from biomass for the removal of metformin in 2 different settings. On one hand, from aqueous solutions and, in another hand, from simulated biological fluids (gastric and intestinal) conjugated with in vivo testing

The development of motor activity: observing spontaneous behavior in fetuses, preterm and term infants

Nowadays, ultrasound examinations in 3D and 4D are promoting the concept of continuity in human motor behavior. The most recent studies on the central nervous have focused both on the general movements of the body and on facial expressions, in order to identify additional evaluation criteria to understand the neuro-behavioral development. The aim of this study is to observe spontaneous motor behavior from the beginning of movement during prenatal life. The observation of human motor behavior is related to the normal function of central nervous system and it can detect early, or even before birth, the integrity of central nervous system (Di Pietro, 2005). In order to describe spontaneous behavior before and after birth, we are going to dedicate the first experiment to code spontaneous motor activity in a group of fetuses and preterm infants at the same gestational age. To code behavior we adopted a new coding scale made by 21 behavioral motor patterns, deriving from the descriptive categories of behavior observed in fetuses, preterm and full-term infants. Comparison between preterm infants and fetuses at the same gestational age was allowed to understand the ontogeny of spontaneous motor activity, but it also helped us to highlight the differences in behavior from the prenatal period to postnatal life. In the second experiment we investigate how appetite condition, as a primary motivational factor, modulates behavior in premature newborns. Results suggest that we can find a modulation in behavior expression also during preterm development and that this modulation is functional to attention seeking and to nutrition. The third experiment compares behavior between full-term and preterm newborns at the same post-conceptional age. Results state there are differences in behavioral motor patterns, as a result of the different behavioral state regulation and coming from the different types of maturational and environmental development. Thanks to these experiments we can confirm that our new behavioral motor patterns coding scale is sensitive to behavior exhibited by fetuses, preterm and full-term infants. Spontaneous behavior is an activity endogenously generated by the CNS which reflects the state of neural development. Behaviors is sensitive to changes in physiological and motivational functions. The study of spontaneous behavior allows us to understand the evolutionary trajectories of specific functions and to inquire into newborn well-being. The value of these observations is twofold, because it opens the way for a new approach both scientific and diagnostic

e-Participation: Promoting Dialogue and Deliberation between Institutions and Civil Society

Information and Communication Technologies (ICT) are increasingly becoming more pervasive of peoples lives, both for individual and collective usage. Hence, it becomes tempting to develop electronic tools that can constitute alternatives to enhance citizenship, in particular tools that can be used in the context of societal debates of public policies. This report explores the conditions to deploying electronic based public participation methodologies and online ICT based participatory processes within public policy processes. It reflects on the challenges, promises and motivations of using ICT to promote dialogue and deliberation among institutions and the civil society. It consists in part of a revision of the techniques and tools commonly used in electronic public participation processes, referring to case studies where these techniques and tools were employed. Special attention was given to cases where the outcome from the public participation process supported a decision process. The conditions of deployment of e-participation processes in public policy formulation were framed within the concept of quality, specifically in the concept of ¿fitness for purpose¿. An electronic tool was designed and implemented, not only featuring dialogue components, but also collaborative ones, as response to some of the identified challenges. Based on the review of e-participation tools and the preliminary usage of the tool developed, a protocol for quality assurance of e-participation tools is offered.JRC.G.9-Econometrics and statistical support to antifrau

JRC Thinkers ‘N’ Tinkers Makerspace - Concept Note

In this concept note, we make the case for creating an in-house makerspace oriented towards the engagement of citizens in technoscientific innovations: the JRC Thinkers ‘N’ Tinkers Makerspace. The idea behind the makerspace is to have a space located in the premises of the JRC that promotes critical thinking and tinkering about technoscientific issues relevant for policy files focusing on their societal implications. We view it as a safe space where we can promote dialogues with civil society through engagements that move beyond discursive methods.JRC.I.1-Modelling, Indicators and Impact Evaluatio

Metric Goodness and Measurement Invariance of the Italian Brief Version of Interpersonal Reactivity Index: A Study With Young Adults

The Interpersonal Reactivity Index (IRI) is a widely used multidimensional measure to assess empathy across four main dimensions: perspective taking (PT) empathic concern (EC) personal distress (PD) fantasy (F). This study aimed to replicate the Italian validation process of the shortened IRI (Interpersonal Reactivity Index) scale in order to confirm its psychometric properties with a sample of young adults. The Gender Measurement Invariance of empathy in this age group was also an objective of the work in order to increase the data on this aspect. A total of 683 Italian university students participated in a non-probabilistic sampling. The 16-item version was confirmed in its four-factor structure but with changes to some items. The model showed good fits with both the CFA and the gender Measurement Invariance. The internal consistency measures were found to be fully satisfactory. Convergent validity was tested by the correlations with the Prosocialness Scale for Adults and The Toronto Alexithymia Scale-20. As hypothesized the measure proved good convergent validity with Prosocialness, i.e., the willingness to assist, help, share, care and empathy with others, and a relevant inverse association with the External Oriented Thinking, characterizing individuals with emotionally poor thinking. This research provided additional evidence for a link between alexithymia and poor empathic abilities in young adults

Crumbling of Amatrice clock tower during 2016 Central Italy seismic sequence: Advanced numerical insights

The dynamic behaviour and the seismic vulnerability of the ancient civic tower of Amatrice, dramatically damaged by the last shocks sequence of 2016 that occurred in Central Italy, have been studied in this paper by means of advanced 3D numerical analyses with the Discrete Element Method (DEM). Thus, a discontinuous approach has been used to assess the dynamic properties and the vulnerability of the masonry structure, through large deformations regulated by the Signorini's law, concerning the impenetrability between the rigid bodies, and by the Coulomb's law, regarding the dry-friction model. Afterward, different values have been assigned to the friction coefficient of the models and real seismic shocks have been applied in the nonlinear analyses. The major purpose of this study is to highlight that relevant data on the real structural behaviour of historical masonry can be provided through advanced numerical analyses. The comparison between the results of the numerical simulation and the survey of the existing crack pattern of the bell tower permitted to validate the approach used. Finally, from the results and conclusions of this case study, it is possible to affirm that the used methodology can be applied to a wide variety of historical masonry structure in Europe

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of synthetic drugs. An increasingly investigated approach is the use of bioactive forages with antiparasitic properties as part of the animal’s diet (nutraceuticals) or as potential sources of novel, natural parasiticides. Chicory (Cichorium intybus) is a multi-purpose crop and one of the most promising bioactive forages in temperate regions, and numerous in vivo trials have explored its potential against parasitic nematodes in livestock. However, it is unclear whether chicory can induce a direct and broad activity against various GI parasites in different livestock species, and the levels of chicory in the diet that are required to exert an efficient antiparasitic effect. Moreover, the mechanisms leading to the reported parasiticidal activity of chicory are still largely unknown, and its bioactive phytochemicals have only recently been investigated. In this review, we summarise the progress in the study of the antiparasitic activity of chicory and its natural bioactive compounds against GI parasites in livestock, through examination of the published literature. The available evidence indicates that feeding chicory can reduce faecal egg counts and/or worm burdens of abomasal nematodes, but not infections with intestinal worms, in ruminants. Highly chicory-rich diets (≥ 70% of chicory dry matter in the diet) may be necessary to directly affect abomasal parasitism. Chicory is known to synthesise several bioactive compounds with potential antiparasitic activity, but most research has been devoted to the role of sesquiterpene lactones (SL). Recent in vitro studies have confirmed direct and potent activity of SL-rich extracts from chicory against different GI helminths of livestock. Chicory SL have also been reported to exhibit antimalarial properties and its potential antiprotozoal activity in livestock remains to be evaluated. Furthermore, the detailed identification of the main antiparasitic metabolites of chicory and their pharmacokinetics need further confirmation. Research gaps and perspectives on the potential use of chicory as a nutraceutical forage and a source of bioactive compounds for parasite control in livestock are discussed

Futures of Work: Perspectives from the Maker Movement

The work presented in this report attempts to explore other realms about the future(s) of work beyond the strongly driven narrative of digital transformation. We have addressed one particular grassroots community, the Maker Movement, which is de facto enabling new models of education, collaborative work, and manufacture. Movements like the Maker Movement can be inspirational of policy making in areas of great complexity and uncertainties as work, employment, jobs are. We suggest that debates about futures of work need to mobilise the imagination, insights and expectations of wide ranges of society. Policy making should be nurturing necessary studies, experiments and conversations until some resilient ideas are found.JRC.I.2-Foresight, Behavioural Insights and Design for Polic