2,599 research outputs found
DEVELOPMENT, CHARACTERIZATION, AND EVALUATION OF SELEGILINE BIONANOSUSPENSIONS USING BUCHANANIA LANZAN AS BIOSTABILIZER
Objective: Development and evaluation of selegiline-loaded bio-nanosuspensions using biopolymer which was isolated from seeds of Buchanania lanzan (Chironji), used as biostabilizer and compared with standard polymer.
Methods: The selegiline-loaded bio-nanosuspensions were prepared using novel biopolymer and standard stabilizer (hydroxypropyl methylcellulose) by sonication solvent evaporation method with different ratios (1%, 2%, 3%, 4%, and 5%) and evaluated for particle size, polydispersity index, zeta potential, pH stability studies, percentage entrapment efficacy, in vitro drug release, and stability studies.
Results: The prepared selegiline bio-nanosuspensions were subjected to the best formulation based on comparison of above-mentioned evaluation parameters, so Fb2 (2%) formulation was found to be the best formulation showing an R2=0.9842, T50% of 32 h and T80% of 70 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release, and Fs5 (5%) formulation was found to be the best formulation showing an R2=0.9564, T50% of 25 h and T80% of 60 h, respectively. According to the release kinetics, the best fit model was found to be Peppas-Korsmeyer with Fickian diffusion (Higuchi matrix) as the mechanism of drug release. The biopolymer provided excellent stability for the formulation and resulting particle size for the best formulation was found to be 360 nm. The best formulation was found to be polydispersity index of 0.43 with zeta potential of −5.12 mV.
Conclusion: The prepared bio-nanosuspensions using biopolymer were found to be safe and compatible with the novel drug delivery for the treatment of depression in comparison of standard polymer
SMART INNOVATIVE APPROACH FOR DESIGNING FLUVOXAMINE LOADED BIO-NANOSUSPENSION FOR THE MANAGEMENT OF DEPRESSION
Objective: Design and evaluation of fluvoxamine loaded bio-nanosuspensions using biopolymer which was isolated from the wood of Santalum album used as the stabilizer.Methods: The main aim of the present investigation was to obtain an ocular drug delivery system with improved stability using biopolymer. The fluvoxamine loaded Bio-nanosuspension was prepared using novel biopolymer isolated from Santalum album by sonication solvent evaporation method with different ratios (1%, 2%, 3%, 4% and 5%) and evaluated for particle size, polydispersity index, zeta potential, pH stability studies, %entrapment efficacy, in vitro drug release, stability studies.Results: The prepared bio-nanosuspension was subjected to the best formulation based on the comparison of above-mentioned evaluation parameters, so Fb3 (3%) formulation was found to be the best formulation showing an R2 value of 0.9744, T50% of 31.3 h and T80% of 50.1 h respectively. According to the release kinetics, the best fit model was found to be Peppas Korsmeyer with Fickian Diffusion (Higuchi Matrix) as the mechanism of drug release. Santalum album provided excellent stability for the formulation, and resulting particle size for the best formulation was found to be 196 nm. The bio-nanosuspension had Polydispersity Index (PDI) of 0.19 with zeta potential of-20mV.Conclusion: The prepared bio-nanosuspension was found to be safe and compatible with the ophthalmic delivery for treatment of depression
High-pressure x-ray diffraction study of bulk and nanocrystalline PbMoO4
We studied the effects of high-pressure on the crystalline structure of bulk
and nanocrystalline scheelite-type PbMoO4. We found that in both cases the
compressibility of the materials is highly non-isotropic, being the c-axis the
most compressible one. We also observed that the volume compressibility of
nanocrystals becomes higher that the bulk one at 5 GPa. In addition, at 10.7(8)
GPa we observed the onset of an structural phase transition in bulk PbMoO4. The
high-pressure phase has a monoclinic structure similar to M-fergusonite. The
transition is reversible and not volume change is detected between the low- and
high-pressure phases. No additional structural changes or evidence of
decomposition are found up to 21.1 GPa. In contrast nanocrystalline PbMoO4
remains in the scheelite structure at least up to 16.1 GPa. Finally, the
equation of state for bulk and nanocrystalline PbMoO4 are also determined.Comment: 18 pages, 4 figure
Spin-lattice coupling mediated giant magnetodielectricity across the spin reorientation in Ca2FeCoO5
The structural, phonon, magnetic, dielectric, and magneto dielectric
responses of the pure bulk Brownmillerite compound Ca2FeCoO5 are reported. This
compound showed giant magneto dielectric response (10%-24%) induced by strong
spin-lattice coupling across its spin reorientation transition (150-250 K). The
role of two Debye temperatures pertaining to differently coordinated sites in
the dielectric relaxations is established. The positive giant
magneto-dielectricity is shown to be a direct consequence of the modulations in
the lattice degrees of freedom through applied external field across the spin
reorientation transition. Our study illustrates novel control of
magneto-dielectricity by tuning the spin reorientation transition in a material
that possess strong spin lattice coupling.Comment: 7 pages, 12 figure
AUTOMATIC DETECTION OF ACCESS POINT LOCATION USING MACHINE LEARNING AND PRIOR MODEL CALIBRATION
Knowledge of the correct location of an access point (AP) is of vital importance within a wireless ecosystem. Techniques are presented herein that support a new AP location identification method that uses prior model calibrations and machine learning (ML) techniques to detect an AP’s location using either received signal strength indicator (RSSI) data or fine time measurement (FTM) protocol data. Among other things, the new method is faster and more accurate than conventional trilateration methods
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The Chandrayaan-2 Large Area Soft X-ray Spectrometer (CLASS)
The CLASS experiment on Chandrayaan-2, the second Indian lunar mission, aims tomap the abundance of the major rock forming elements on the lunar surface using the technique of X-ray fluorescence during solar flare events. CLASS is a continuation of the successful C1XS [1] XRF experiment on Chandrayaan-1. CLASS is designed to provide lunar mapping of elemental abundances with a nominal spatial resolution of 25 km (FWHM) from a 200 km polar, circular orbit of Chandrayaan-2
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