4 research outputs found

    Das LĂ€ndliche als kulturelle Kategorie: aktuelle kulturwissenschaftliche Perspektiven auf Stadt-Land-Beziehungen

    Get PDF
    Das LĂ€ndliche hat Konjunktur. Zwischen medialer »Landlust« und realem Strukturwandel in den lĂ€ndlichen RĂ€umen Europas differenziert es sich dynamisch aus. Idylle oder Problemregion? Arbeitsort oder Freizeitpark? ReprĂ€sentationen und lebensweltliche Erfahrungen des LĂ€ndlichen avancieren zu einem alltagskulturellen Konfliktfeld, auf dem sich vor einem historischen Hintergrund elementare Problemlagen der Gegenwart und die KomplexitĂ€t von kulturellen Land-Stadt-Beziehungen spiegeln.Die BeitrĂ€ge des Bandes liefern hierzu Einsichten aus der Forschungsperspektive der EuropĂ€ischen Ethnologie und rahmen das Thema damit fĂŒr historische und gegenwartsbezogene Kulturanalysen begrifflich, methodisch und theoretisch

    Wallaceochromis gen. nov, a new chromidotilapiine cichlid genus (Pisces: Perciformes) from West Africa

    No full text
    Lamboj, Anton, Trummer, Franziska, Metscher, Brian D. (2016): Wallaceochromis gen. nov, a new chromidotilapiine cichlid genus (Pisces: Perciformes) from West Africa. Zootaxa 4144 (1): 124-130, DOI: http://doi.org/10.11646/zootaxa.4144.1.

    Nicotinamide for the treatment of heart failure with preserved ejection fraction

    Get PDF
    Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD(+)). Elevating NAD(+) by oral supplementation of its precursor, nicotinamide, improved diastolic dysfunction induced by aging (in 2-year-old C57BL/6J mice), hypertension (in Dahl salt-sensitive rats), or cardiometabolic syndrome (in ZSF1 obese rats). This effect was mediated partly through alleviated systemic comorbidities and enhanced myocardial bioenergetics. Simultaneously, nicotinamide directly improved cardiomyocyte passive stiffness and calcium-dependent active relaxation through increased deacetylation of titin and the sarcoplasmic reticulum calcium adenosine triphosphatase 2a, respectively. In a long-term human cohort study, high dietary intake of naturally occurring NAD(+) precursors was associated with lower blood pressure and reduced risk of cardiac mortality. Collectively, these results suggest NAD(+) precursors, and especially nicotinamide, as potential therapeutic agents to treat diastolic dysfunction and HFpEF in humans
    corecore