Research Report - October 2009. Elaboration of the Module: Definition of the Programme

Alternative innovative didactic methodology is needed to reduce premature school drop out,particularly of young people at risk of exclusion, such as migrants, ethnic groups and children/teenagers from difficult socio-economic background). The key point is to modify the way to deliver learning. Cultural enrichment through young interestas such as music and art, use of technologies, social competencies, problem-solving skills incomputer science, autonomy and sense of purpose may help childhood and adolescence to achieve an improved engagement in school and a sense of educational accomplishmen

Fourth order gravity and experimental constraints on Eddington parameters

PPN-limit of higher order theories of gravity represents a still controversial matter of debate and no definitive answer has been provided, up to now, about this issue. By exploiting the analogy between scalar-tensor and fourth-order theories of gravity, one can generalize the PPN-limit formulation. By using the definition of the PPN-parameters $\gamma$ and $\beta$ in term of the $f(R)$ derivatives, we show that a family of third-order polynomial theories, in the Ricci scalar $R$, turns out to be compatible with the PPN-limit and the deviation from General Relativity theoretically predicted agree with experimental data.Comment: 7 pages, 3 figure

Reconciling dark energy models with f(R) theories

Higher order theories of gravity have recently attracted a lot of interest as alternative candidates to explain the observed cosmic acceleration without the need of introducing any scalar field. A critical ingredient is the choice of the function f(R) of the Ricci scalar curvature entering the gravity Lagrangian and determining the dynamics of the universe. We describe an efficient procedure to reconstruct f(R) from the Hubble parameter $H$ depending on the redshift z. Using the metric formulation of f(R) theories, we derive a third order linear differential equation for f(R(z)) which can be numerically solved after setting the boundary conditions on the basis of physical considerations. Since H(z) can be reconstructed from the astrophysical data, the method we present makes it possible to determine, in principle, what is the f(R) theory which best reproduces the observed cosmological dynamics. Moreover, the method allows to reconcile dark energy models with f(R) theories finding out what is the expression of f(R) which leads to the same H(z) of the given quintessence model. As interesting examples, we consider "quiessence" (dark energy with constant equation of state) and the Chaplygin gas.Comment: 15 pages, 4 figures, accepted for publication on Physical Review

A screening method for ranking chemicals by their fate and behaviour in the environment and potential toxic effects in humans following non-occupational exposure

A large number of chemicals are released intentionally or unintentionally into the environment each year. These include thousands of substances that are currently listed worldwide and several hundred new substances added annually (Mücke et al., 1986). When these compounds are used, they can reach microorganisms, plants, animals and man either in their original state or in the form of reaction and degradation products via air, water, soil or foodstuffs. Hence environmental chemicals can occur in practically all environmental compartments and ecosystems. It is not feasible to conduct assessments of human exposure and possible associated health effects for all chemicals. Even if the necessary resources were available, reliable data for a quantitative evaluation are likely to be absent in most cases. This has led to the development of schemes for prioritising compounds likely to be of environmental significance. Such schemes can be used to direct future research efforts towards the prioritised compounds. This study was commissioned by the Department of Health (DH) as part of a broader research activity that aims to identify key priority chemicals of concern to human health at routine levels of environmental exposure. The main pathways of human exposure are shown in Figure 1.1. A review of the principal prioritisation schemes used by different organisations to assess the significance of chemical release into the environment has been conducted by the MRC Institute for Environment and Health (IEH, 2003). This review showed that the approaches used by different organisations vary widely, depending on the initial reasons for which the schemes were developed. The basic information presented in the review was used to develop a simple screening method for ranking chemicals. The model used in this prioritisation scheme is outlined in Figure 1.2. The main purpose in developing the prioritisation scheme for DH was to develop a dedicated priority setting method capable of identifying chemicals in air, water, soil and foodstuffs that might pose a significant risk to human health following low level environmental exposure. The methodology was developed in order to identify compounds that required further assessment and those that had data gaps. More detailed risk assessments were conducted at a later stage on those compounds prioritised as being of high importancea. The screening methodology was developed for ‘existing chemicals’ as these are of greatest concern because data on their toxicity and/or fate and behaviour are often unknownb. The production of a priority list was designed to highlight compounds that required further regulatory measures to reduce exposure of the general population and for which an in-depth risk characterisation would be necessary to assist in the evaluation and implementation of activities for reducing environmental risks. This might include an assessment of the costs of such risks to human health and the costs of reduction measures. As the scheme also aimed to identify data gaps that might warrant further investigation, the application of default categories for chemicals with no data was also considered. The overall aim was to develop a screening methodology that is quick, clear and simple to use and that can easily be revised to take into account new information on compounds as and when it becomes available. a Benzene (IEH Report on Benzene in the Environment, R12); 4,6-dichlorocresol, hexachloro-1,3-butadiene, tetrachlorobenzene, 2,4,6-trichlorophenol (reports to DH; available from MRC Institute for Environment and Health b ‘Existing Substances’ are those that were placed in the European Union (EU) market before 1981. Prior to 1981 regulatory requirements were related to products intended for certain uses (e.g. veterinary medicines) and did not require assessment of the hazardous properties of any substance before they were released into the market. For substances placed on the market after 1981 (classified as ‘New Substances’) there is a legal requirement to conduct such assessments. Regulatory agencies require the collection of extensive documentation for safety before a chemical, for example, can be used in foods or commercial products. IEH Web Report W14, posted March 2004 at http://www.le.ac.uk/ieh/ 4 This report describes how physicochemical properties and toxicological data were incorporated into a screening model to assess the potential fate and transfer of chemicals between different environmental compartments and to predict the potential human exposure to toxic chemicals through the inhalation of contaminated air and the ingestion of water and food. It must be stressed, however, that the method devised is a simple screening process and that a more detailed assessment is necessary to determine the potential transfer through the foodchain of a chemical and the full extent of any adverse health effects. Sections 2 and 4 present the physicochemical properties, toxicological data and algorithms used to screen the compounds. Section 3 summarises the groups of chemicals that were included in the screening process. The results of the prioritisation scheme and comments on their limitations and constraints are presented in Section 5

T-cell responses in oiled guillemots and swans in a rehabilitation setting

This article has been accepted for publication in the Archives of Environmental Contamination and Toxicology. The final version can be accessed from the link below.This article has been made available through the Brunel Open Access Publishing Fund.Aquatic birds are commonly affected by oil spills. Despite rehabilitation efforts, the majority of rehabilitated common guillemots (Uria aalge) do not survive, whereas mute swans (Cygnus olor) tend to have higher post-release survival. Polyaromatic hydrocarbons (PAHs) present in crude oil and diesel are immunotoxic in birds affecting cell-mediated responses to immunogens. Because it is a target of PAH toxicity, T-lymphocyte response to controlled mitogen administration (phytohemagglutinnin test) was investigated in a scoping study as a potentially useful minimally invasive in vivo test of cell-mediated immunity. The test was performed on 69 mute swans and 31 common guillemots stranded on the Norfolk and Lincolnshire coastline and inland waterways in England (UK)either due to injury or to contamination with crude or diesel oil. T-lymphocyte response was significantly decreased in swans with greater oil scores. T-lymphocyte responses were also decreased in guillemots, but this finding was not statistically significant

Designing sustainable medical devices

Stakeholders in the medical device manufacturing industry are becoming more concerned about the environmental impact of their products and processes. The consumers are also becoming more aware of the negative impact that manufacturers can have on the environment. Government initiatives continue to increase environmental awareness through the development of new policy and legislation, encouraging industry to become more accountable for the environmental impact of their products and operations. The ISO 14001 standard, Environmental Management Systems-Requirements with Guidance for Use, sets guidelines to enable businesses to recognize the environmental effects of their products and processes. Departments can use the tool to set targets to lower the environmental impact and identify areas of high environmental concern when designing, purchasing, and marketing products. Research in these areas will be used to develop the environmental scoring tool to aid in the design of future sustainable medical devices

The Rainbow Prim Algorithm for Selecting Putative Orthologous Protein Sequences

We present a selection method designed for eliminating species redundancy in clusters of putative orthologous sequences, to be applied as a post-processing procedure to pre-clustered data obtained from other methods. The algorithm can always zero-out the cluster redundancy while preserving the number of species of the original cluster