General principles of contract law (1993)

This publication outlines some general principles of law that govern the performance of contracts.Reviewed October 1, 1993

Liability of farm employers (1980)

Farm owners and operators who hire employees increase their potential liability. The farm employer may be held liable for the acts of employees, as well as for injuries to them. This guide discusses generally the farm employer's exposure to liability and steps that could be taken to protect against such liability.Revised 7/80/12M

Marital trusts

"Estate planning provides for orderly distribution of your assets during your life and at death. Estate planning also minimizes the impact that federal and state transfer taxes can have on your estate. This guide takes a look at the estate planning tool called the marital trust. The marital trust can reduce federal estate taxes and provide for professional management of assets passed on to heirs at death."--First page.Stephen F. Matthews and Timothy W. Triplett (Department of Agricultural Economics, College of Agriculture)8/78/8

Your rights under condemnation in Missouri

File: Agr. Econ 3."Each year federal, state and local government units condemn many acres of land. Farmers and others faced with this prospect must be familiar with the meaning and procedures of condemnation."--First page.Stephen F. Matthews and Timothy W. Triplett (Department of Agricultural Economics, College of Agriculture)Rev. 4/77/8

Suitability of external controls for drug evaluation in Duchenne muscular dystrophy

OBJECTIVE: To evaluate the suitability of real-world data (RWD) and natural history data (NHD) for use as external controls in drug evaluations for ambulatory Duchenne muscular dystrophy (DMD). METHODS: The consistency of changes in the 6-minute walk distance (Δ6MWD) was assessed across multiple clinical trial placebo arms and sources of NHD/RWD. Six placebo arms reporting 48-week Δ6MWD were identified via literature review and represented 4 sets of inclusion/exclusion criteria (n = 383 patients in total). Five sources of RWD/NHD were contributed by Universitaire Ziekenhuizen Leuven, DMD Italian Group, The Cooperative International Neuromuscular Research Group, ImagingDMD, and the PRO-DMD-01 study (n = 430 patients, in total). Mean Δ6MWD was compared between each placebo arm and RWD/NHD source after subjecting the latter to the inclusion/exclusion criteria of the trial for baseline age, ambulatory function, and steroid use. Baseline covariate adjustment was investigated in a subset of patients with available data. RESULTS: Analyses included ∼1,200 patient-years of follow-up. Differences in mean Δ6MWD between trial placebo arms and RWD/NHD cohorts ranged from -19.4 m (i.e., better outcomes in RWD/NHD) to 19.5 m (i.e., worse outcomes in RWD/NHD) and were not statistically significant before or after covariate adjustment. CONCLUSIONS: We found that Δ6MWD was consistent between placebo arms and RWD/NHD subjected to equivalent inclusion/exclusion criteria. No evidence for systematic bias was detected. These findings are encouraging for the use of RWD/NHD to augment, or possibly replace, placebo controls in DMD trials. Multi-institution collaboration through the Collaborative Trajectory Analysis Project rendered this study feasible

Lifetime gifts

"Estate planning provides for orderly distribution of your assets during your lifetime and at death. Estate planning also minimize the impact that federal and state transfer taxes can have on your estate. This guide has information on lifetime gifts as one of the various legal tools available to the estate planner."--First page.Stephen F. Matthews and Timothy W. Triplett (Department of Agricultural Economics, College of Agriculture)New 8/78/8

Should you incorporate your farm?

"Because of high estate, gift, inheritance, and income taxes and other reasons, many Missouri farmers are interested in forms of business organizations that help minimize taxes and maximize the inheritance for their children and other heirs. Three basic forms of farm business organizations are (1) sole proprietorship, (2) partnership, and (3) corporation."--First page.Stephen F. Matthews and Timothy W. Triplett (Department of Agricultural Economics, College of Agriculture)Revised 5/79/12