Складові компоненти забезпечення прав та свобод людини в досудових стадіях кримінального процесу України

Третьякова, М. В. Складові компоненти забезпечення прав та свобод людини в досудових стадіях кримінального процесу України / М. В. Третьякова // Вісник Харківського національного університету внутрішніх справ. – 2008. – Вип. 43. – С. 106-115.Розглянуто складові компоненти (а саме – принципи кримінально-процесуального права, рішення в кримінальному судочинстві, процесуальні дії та заходи процесуального примусу), взаємодіючи між собою, в рівній мірі забезпечують належне функціонування механізму забезпечення прав і свобод людини в досудових стадіях кримінального процесу. Рассмотрены компоненты (а именно - принципы уголовно-процессуального права, решение в уголовном судопроизводстве, процессуальные действия и меры процессуального принуждения), взаимодействуя между собой, в равной степени обеспечивают надлежащее функционирование механизма обеспечения прав и свобод человека в досудебных стадиях уголовного процесса. The constituent components (namely - principles of criminal procedure law, decisions in criminal proceedings, procedural actions and measures of procedural coercion) are considered, interacting with each other, equally ensuring the proper functioning of the mechanism of ensuring human rights and freedoms in the pre-trial stages of criminal proceedings

Designing of rational structure of range of insulating protective clothing on the basis of the principles of transformation

The aim of this work is to develop a range structure of insulating change of clothes with predictable characteristics for the employees of nuclear power plants (NPP). It was applied a systematic approach to solve the assigned tasks, which made it possible to use the principles of transformation through the gradual changes in design and complete of protective clothing. The implementation of the assigned tasks was carried out using the method of structural optimization of construction of insulating protective clothing. The rational structure of range of insulating change of clothes with predictable coefficient of protection, weight and cost was formed on the basis of the principles of transformation by the method of structural optimization. It was obtained the formula for calculation of protection coefficient under constraints on weight, cost, number of material layers (taking into consideration the non-linearity of the objective function), under constraints and discretization of initial information for the packages of protective clothing. Structural and logical matrix for insulating change of protective clothing was formed. There were proposed a structure of insulating change of clothing for NPP employees, structural and technological solutions for the products from the product range. Task-oriented selection of modules and methods of their transformation within the designed object was carried out

Fashion design in a multicultural space

The collective monograph contains the results of the synthesis of theoretical materials, as well as the authors` applied research developments on the design of the clothes of different assortment and purpose, made from different materials considering the modern scientific methods

Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

The c-MET receptor can be overexpressed, amplified, or mutated in solid tumours including small cell lung cancer (SCLC). In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal transduction was detected, namely adducin-α [S724], adducin-γ [S662], CREB [S133], ERK1 [T185/Y187], ERK1/2 [T202/Y204], ERK2 [T185/Y187], MAPKK (MEK) 1/2 [S221/S225], MAPKK (MEK) 3/6 [S189/S207], RB [S612], RB1 [S780], JNK [T183/Y185], STAT3 [S727], focal adhesion kinase (FAK) [Y576/S722/S910], p38α-MAPK [T180/Y182], and AKT1[S473] and [T308]. Conversely, inhibition of phosphorylation by HGF in protein kinase C (PKC), protein kinase R (PKR), and also CDK1 was identified. Phosphoantibody-based immunohistochemical analysis of SCLC tumour tissue and microarray established the role of c-MET in SCLC biology. This supports a role of c-MET activation in tumour invasive front in the tumour progression and invasion involving FAK and AKT downstream. The c-MET serves as an attractive therapeutic target in SCLC, as shown through small interfering RNA (siRNA) and selective prototype c-MET inhibitor SU11274, inhibiting the phosphorylation of c-MET itself and its downstream molecules such as AKT, S6 kinase, and ERK1/2. Investigation of mechanisms of invasion and, ultimately, metastasis in SCLC would be very useful with these signal transduction molecules

Lactic acid fermentation as a tool to enhance the antioxidant properties of Myrtus communis berries

Background: Myrtle (Myrtus communis L.) is a medicinal and aromatic plant belonging to Myrtaceae family, which is largely diffused in the Mediterranean areas and mainly cultivated in Tunisia and Italy. To the best of our knowledge, no studies have already considered the use of the lactic acid fermentation to enhance the functional features of M. communis. This study aimed at using a selected lactic acid bacterium for increasing the antioxidant features of myrtle berries, with the perspective of producing a functional ingredient, dietary supplement or pharmaceutical preparation. The antioxidant activity was preliminarily evaluated through in vitro assays, further confirmed through ex vivo analysis on murine fibroblasts, and the profile of phenol compounds was characterized. Results: Myrtle berries homogenate, containing yeast extract (0.4%, wt/vol), was fermented with Lactobacillus plantarum C2, previously selected from plant matrix. Chemically acidified homogenate, without bacterial inoculum and incubated under the same conditions, was used as the control. Compared to the control, fermented myrtle homogenate exhibited a marked antioxidant activity in vitro. The radical scavenging activity towards DPPH increased by 30%, and the inhibition of linoleic acid peroxidation was twice. The increased antioxidant activity was confirmed using Balb 3 T3 mouse fibroblasts, after inducing oxidative stress, and determining cell viability and radical scavenging activity through MTT and DCFH-DA assays, respectively. The lactic acid fermentation allowed increased concentrations of total phenols, flavonoids and anthocyanins, which were 5–10 times higher than those found for the non-fermented and chemically acidified control. As shown by HPLC analysis, the main increases were found for gallic and ellagic acids, and flavonols (myricetin and quercetin). The release of these antioxidant compounds would be strictly related to the esterase activities of L. plantarum. Conclusions: The lactic acid fermentation of myrtle berries is a suitable tool for novel applications as functional food dietary supplements or pharmaceutical preparations

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

BACKGROUND: A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors. PRESENTATION OF THE HYPOTHESIS: Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by glial cells are among the distal causes in the genotype-to-phenotype chain leading to the development of schizophrenia. These factors include neuregulin, insulin-like growth factor I, insulin, epidermal growth factor, neurotrophic growth factors, erbB receptors, phosphatidylinositol-3 kinase, growth arrest specific genes, neuritin, tumor necrosis factor alpha, glutamate, NMDA and cholinergic receptors. A genetically and epigenetically determined low baseline of glial growth factor signaling and synaptic strength is expected to increase the vulnerability for additional reductions (e.g., by viruses such as HHV-6 and JC virus infecting glial cells). This should lead to a weakening of the positive feedback loop between the presynaptic neuron and its targets, and below a certain threshold to synaptic destabilization and schizophrenia. TESTING THE HYPOTHESIS: Supported by informed conjectures and empirical facts, the hypothesis makes an attractive case for a large number of further investigations. IMPLICATIONS OF THE HYPOTHESIS: The hypothesis suggests glial cells as the locus of the genes-environment interactions in schizophrenia, with glial asthenia as an important factor for the genetic liability to the disorder, and an increase of prolactin and/or insulin as possible working mechanisms of traditional and atypical neuroleptic treatments

Cancer Biomarker Discovery: The Entropic Hallmark

Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases

Правовые основы обеспечения безопасности субъектов, которые ведут уголовный процесс

Третьякова, М. В. Правові основи забезпечення безпеки суб’єктів, що ведуть кримінальний процес [Електронний ресурс] / М. В. Третьякова // Форум права. – 2010. – № 2. – С. 508–512. – Режим доступу: http://www.nbuv.gov.ua/e-journals/FP/2010- 2/10tmvvkp.pdf.Третьякова М. В. "Правові основи забезпечення безпеки суб’єктів, що ведуть кримінальний процес." Форум права 2 (2010): 508-512.Розглядаються питання забезпечення безпеки суб’єктів кримінально-процесуальної діяльності, зокрема, які ведуть кримінальний процес. Зосереджується увага на висвітленні проблем правової регламентації забезпечення безпеки працівників суду, правоохоронних органів та їх близьких родичів у кримінальному судочинстві за чинним законодавством України.The questions of providing of safety of subjects of criminal procedure activity are considered, in particular, which conduct criminal procedure. Attention is concentrated on the problems of legal regulation of providing of safety of employees of court, law enforcement organs and their near relation in a criminal trial in obedience to the working labor legislation of Ukraine.Рассматриваются вопросы обеспечения безопасности субъектов криминально-процессуальной деятельности, в частности, которые ведут уголовный процесс. Сосредоточивается внимание на освещении проблем правовой регламентации обеспечения безопасности работников суда, правоохранительных органов и их близких родственников в уголовном судопроизводстве согласно действующего законодательства Украины

Классификация субъектов уголовно-процессуальной деятельности на основании обеспечения прав и свобод

Третьякова, М. В. Класифікація суб’єктів кримінально-процесуальної діяльності на підставі забезпечення прав та свобод / М. В. Третьякова // Вісник Харківського національного університету внутрішніх справ. – 2007. – Вип. 39. – С. 183-187.Запропоновано класифікацію суб’єктів кримінально-процесуальної діяльності на підставі забезпечення прав та свобод. A classification of subjects of criminal procedure activities on the basis of ensuring rights and freedoms is proposed. Предложена классификация субъектов уголовно-процессуальной деятельности на основании обеспечения прав и свобод

Development of nuclear technologies in the Institute for Nuclear Research, National Academy of Sciences of Ukraine

Results obtained in the Institute for Nuclear Research of NAS of Ukraine on the development and use of nu-clear technologies implemented in the course of the fulfillment of budget themes, scientific-technical and techno-logical projects as well as innovative programs were outlined