215 research outputs found
Identifying and characterizing a “consumer medical vocabulary”.
Problem: To identify and analyze similarities and differences between professional, intennediary ("media"), and lay medical vocabularies (e.g., myocardial infarction vs. heart attack)
Returns to buying upward revision and selling downward revision stocks: evidence from Canada.
Purpose: The purpose of this paper is to investigate the role of earnings forecast revisions by equity analysts in predicting Canadian stock returns Design/methodology/approach: The sample covers 420 Canadian firms over the period 1998-2009. It analyses investors’ reactions to 27,271 upward revisions and 32,005 downward revisions of analysts’ forecasts for Canadian quoted companies. To test whether analysts’ earnings forecast revisions affect stock return continuation, forecast revision portfolios similar to Jegadeesh and Titman (2001) are constructed. The paper analyses the returns gained from a trading strategy based on buying the strong upward revisions portfolio and short selling the strong downward revisions portfolio. It also separates the sample into upward and downward revisions. Findings: The authors find that new information in the form of analyst forecast revisions is not impounded efficiently into stock prices. Significant returns persist for a trading strategy that buys stocks with recent upward revisions and short sells stocks with recent downward revisions. Good news is impounded into stock prices more slowly than bad news. Post-earnings forecast revisions drift is negatively related to analyst coverage. The effect is strongest for stocks with greatest number of upward revisions. The introduction of the better disclosure standards has made the Canadian stock market more efficient. Originality/value: The paper adds to the limited evidence on the effect of analyst forecast revisions on the returns of Canadian stocks. It sheds light on the importance of analysts’ earnings forecast information and offers support for the investor conservatism and information diffusion hypotheses. It also shows how policy can improve market efficiency
The impacts of stock characteristics and regulatory change on mutual fund herding in Taiwan.
This article analyses the trading activity of Taiwanese open-end equity mutual fund herding behaviour over the period of 1996-2008. We found evidence of both directional and directionless herding. We also found that sell-side fund herding leads to price stabilization, whereas buy-side herding results in prices adjusting slowly. We found that the abolition of qualified foreign institutional investor (QFII) has reduced directionless and sell-side herding but has had no effect on buy-side herding
The impact of economic freedom on financial analysts' earnings forecast: Evidence from the Asia-Pacific region
This study investigates the impact of economic freedom (EcF) on analysts’ earnings forecast (AEF) accuracy. EcF is measured from five aspects: Government, Protection, Money, Trade, and Regulation. With the sample of 7,014 firms from 12 economies in the Asia-Pacific region over the 18-year period, this study finds an optimistic bias in AEFs. The optimistic bias is stronger for large firms, value firms, stock with high analyst coverage, and low dispersion in AEFs. Also, the optimistic bias is stronger from analysts in economies with less EcF than in more freedom ones. Analysts are making more accurate earnings forecasts for firms in economies with more EcF. In addition, the study finds the optimism bias reduced the earnings forecast accuracy. These findings may suggest that an increase of EcF would lead to more transparent financial statements, which further reduces the analysts’ forecast bias
Shifts in stability and control effectiveness during evolution of Paraves support aerial maneuvering hypotheses for flight origins
The capacity for aerial maneuvering shaped the evolution of flying animals.
Here we evaluate consequences of aviaian morphology for aerial performance
(1,2) by quantifying static stability and control effectiveness of physical
models (3) for numerous taxa sampled from within the lineage leading to birds
(Paraves, 4). Results of aerodynamic testing are mapped phylogenetically (5-9)
to examine how maneuvering characteristics correlate with tail shortening,
fore- and hindwing elaboration, and other morphological features (10). In the
evolution of the Avialae we observe shifts from static stability to inherently
unstable aerial planforms; control effectiveness also migrated from tails to
the forewings. These shifts suggest that some degree of aerodynamic control and
and capacity for maneuvering preceded the evolution of strong power stroke. The
timing of shifts also suggests some features normally considered in light of
development of a power stroke may play important roles in control.Comment: 12 pages, 6 figures, 1 supplemental figures and 5 supplemental table
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Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.
ObjectivesThe intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated.DesignTo examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp+/+) and knockout (Cnlp-/-) mice underwent cecal-ligation and puncture (CLP) followed by the assessment of septic mortality and morbidity as well as histological, biochemical, immunological, and transcriptomic analyses in the ileal tissues. We also evaluated the prophylactic and therapeutic efficacies of vitamin D3 (an inducer of endogenous cathelicidin) in the CLP-induced murine polymicrobial sepsis model.ResultsThe ileal expression of cathelicidin was increased by three-fold after CLP, peaking at 4 h. Knockout of Cnlp significantly increased 7-day mortality and was associated with a higher murine sepsis score. Alcian-blue staining revealed a reduced number of mucin-positive goblet cells, accompanied by reduced mucin expression. Increased number of apoptotic cells and cleavage of caspase-3 were observed. Cnlp deletion increased intestinal permeability to 4kD fluorescein-labeled dextran and reduced the expression of tight junction proteins claudin-1 and occludin. Notably, circulating bacterial DNA load increased more than two-fold. Transcriptome analysis revealed upregulation of cytokine/inflammatory pathway. Depletion of Cnlp induced more M1 macrophages and neutrophils compared with the wild-type mice after CLP. Mice pre-treated with cholecalciferol (an inactive form of vitamin D3) or treated with 1alpha, 25-dihydroxyvitamin D3 (an active form of VD3) had decreased 7-day mortality and significantly less severe symptoms. Intriguingly, the administration of cholecalciferol after CLP led to worsened 7-day mortality and the associated symptoms.ConclusionsEndogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and macrophages in polymicrobial sepsis. Our data suggested that 1alpha, 25-dihydroxyvitamin D3 but not cholecalciferol is a potential therapeutic agent for treating sepsis
Photoconductivity of biased graphene
Graphene is a promising candidate for optoelectronic applications such as
photodetectors, terahertz imagers, and plasmonic devices. The origin of
photoresponse in graphene junctions has been studied extensively and is
attributed to either thermoelectric or photovoltaic effects. In addition, hot
carrier transport and carrier multiplication are thought to play an important
role. Here we report the intrinsic photoresponse in biased but otherwise
homogeneous graphene. In this classic photoconductivity experiment, the
thermoelectric effects are insignificant. Instead, the photovoltaic and a
photo-induced bolometric effect dominate the photoresponse due to hot
photocarrier generation and subsequent lattice heating through electron-phonon
cooling channels respectively. The measured photocurrent displays polarity
reversal as it alternates between these two mechanisms in a backgate voltage
sweep. Our analysis yields elevated electron and phonon temperatures, with the
former an order higher than the latter, confirming that hot electrons drive the
photovoltaic response of homogeneous graphene near the Dirac point
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