A Single‐Cell Perspective of the Mammalian Liver in Health and Disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/1/hep31149_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/2/hep31149.pd

Optical sensor based on hybrid LPG/FBG in D-fiber for simultaneous refractive index and temperature measurement

A dual-parameter optical sensor has been realized by UV-writing a long-period and a Bragg grating structure in D-fiber. The hybrid configuration permits the detection of the temperature from the latter and measuring the external refractive index from the former responses, respectively. The employment of the D-fiber allows as effective modification and enhancement of the device sensitivity by cladding etching. The grating sensor has been used to measure the concentrations of aqueous sugar solutions, demonstrating the potential capability to detect concentration changes as small as 0.01%

Mass Ratio Distribution of Hierarchical Triple Systems from the LAMOST-MRS Survey

Hierarchical triple-star systems consists of three components organised into an inner binary ($M_{1}$,$M_{2}$) and a more distant outer tertiary ($M_{3}$) star. The LAMOST Medium-Resolution Spectroscopic Survey (LAMOST-MRS) has offered a great sample for the study of triple system populations. We used the Peak Amplitude Ratio (PAR) method to obtain the mass ratio ($q_\mathrm{{in}}$, $q_\mathrm{{out}}$) of a triple system from its normalised spectrum. By calculating Cross-Correlation Function (CCF), we determined the correlation between the mass ratio $q_\mathrm{{out}}$ ($M_{3}$/($M_{1}$+$M_{2}$)) and the amplitude ratio ($A_{3}$/($A_{1}$+$A_{2}$)). We derived $q_\mathrm{{in}}$ of $0.5-1.0$ and $q_\mathrm{{out}}$ between 0.2 and 0.8. By fitting a power-law function of the corrected $q_\mathrm{{in}}$ distribution, the $\gamma_\mathrm{{in}}$ are estimated to be $-0.654\pm2.915$, $4.304\pm1.125$ and $11.371\pm1.309$ for A, F and G type stars. The derived $\gamma_\mathrm{{in}}$-values increase as the mass decrease, indicating that less massive stars are more likely to have companion stars with similar masses. By fitting a power-law function of the corrected $q_\mathrm{{out}}$ distribution, the ${\gamma_\mathrm{{out}}}$ are estimated to be $-2.016\pm0.172$, $-1.962\pm0.853$ and $-1.238\pm0.141$ for G, F and A type stars, respectively. The ${\gamma_\mathrm{{out}}}$-values show a trend of growth toward lower primary star masses

hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/1/hep30921-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/2/hep30921.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/3/hep30921_am.pd

Prognostic and therapeutic implications of iron-related cell death pathways in acute myeloid leukemia

Acute myeloid leukemia (AML) is a blood cancer that is diverse in terms of its molecular abnormalities and clinical outcomes. Iron homeostasis and cell death pathways play crucial roles in cancer pathogenesis, including AML. The objective of this study was to examine the clinical significance of genes involved in iron-related cell death and apoptotic pathways in AML, with the intention of providing insights that could have prognostic implications and facilitate the development of targeted therapeutic interventions. Gene expression profiles, clinical information, and molecular alterations were integrated from multiple datasets, including TCGA-LAML and GSE71014. Our analysis identified specific molecular subtypes of acute myeloid leukemia (AML) displaying varying outcomes, patterns of immune cell infiltration, and profiles of drug sensitivity for targeted therapies based on the expression of genes involved in iron-related apoptotic and cell death pathways. We further developed a risk model based on four genes, which demonstrated promising prognostic value in both the training and validation cohorts, indicating the potential of this model for clinical decision-making and risk stratification in AML. Subsequently, Western blot analysis showed that the expression levels of C-Myc and CyclinD1 were significantly reduced after CD4 expression levels were knocked down. The findings underscore the potential of iron-related cell death pathways as prognostic biomarkers and therapeutic targets in AML, paving the way for further research aimed at understanding the molecular mechanisms underlying the correlation between iron balance, apoptosis regulation, and immune modulation in the bone marrow microenvironment

Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors

<p>Abstract</p> <p>Background</p> <p>Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL.</p> <p>Methods</p> <p>The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano staging system for gastrointestinal non-Hodgkin's lymphoma.</p> <p>Results</p> <p>The predominant pathologic subtype among Chinese patients with PGL in our study was diffuse large B cell lymphoma (DLBCL), followed by mucosa-associated lymphoid tissue (MALT) lymphoma. Among the 57 patients with gastric DLBCL, 20 patients (35.1%) were classified as the germinal center B cell-like (GCB) subtype and 37 patients (64.9%) as the non-GCB subtype. The 83 patients had a five-year overall survival (OS) and event-free survival (EFS) of 52% and 59%, respectively. Cox regression analysis showed that stage-modified international prognostic index (IPI) and performance status (PS) were independent predictors of survival. In the 67 B-cell lymphoma patients who received chemotherapy, 36 patients treated with rituximab (at least 3 cycles) had a mean OS of 72 months (95% CI 62-81) versus 62 months (95% CI 47-76) for patients without rituximab treatment (P = 0.021).</p> <p>Conclusion</p> <p>The proportion of Chinese gastric DLBCL cases with non-GCB subtype was higher than the GCB subtype. Stage-modified IPI and PS were effective prognostic factors in Chinese patients with PGL. Our data suggested that primary gastric B-cell lymphoma might have an improved outcome with rituximab in addition to chemotherapy. More studies are necessary, preferentially large prospective randomized clinical trials to obtain more information on the impact of the rituximab in the primary gastric B-cell lymphoma.</p

Research on a new fiber-optic axial pressure sensor of transformer winding based on fiber Bragg grating

Abstract Based on the principle of the fiber Bragg grating, a new type of fiber-optic pressure sensor for axial force measurement of transformer winding is designed, which is designed with the structure of bending plate beam, the optimization of the packaging process, and material of the sensor. Through the calibration experiment to calibrate the sensor, the field test results of the Taikai transformer factory show that the sensitivity of the sensor is 0.133 pm/kPa and the repeatability error is 2.7% FS. The data of the fiber-optic pressure sensor in different positions maintain consistent and repeatable, which can meet the requirement of the real-time monitoring of the axial force of transformer winding