Additional file 1 of Assessing the transportability of clinical prediction models for cognitive impairment using causal models

Additional file 1

WGHS active migraineurs (N = 3,003^*) with aura or migraine characteristic.

<p>*An additional 2,119 WGHS participants reported prior but not active migraine compared with 18,172 WGHS participants reported never experiencing migraine.</p

Inheritance model^# selected with the AIC.

#<p>Models (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>): “-” = null, basic, “sub” = subset, “inv. sub” = inverse subset, general.</p>∧<p>Migraine characteristics: aura, pulsation, unipain ( = unilateral pain), sound ( = phonophobia), light ( = photophobia), duration of 4–72 hours ( = longdur), nausea, aggravation by physical activity ( = aggrphys), severity inhibits daily activities ( = inhibit), ≥6 attacks/year ( = freq).</p><p>“*” indicates models with significant LLR test p-values (<0.05) after adjustment for multiple hypothesis testing (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>).</p

Inheritance model^# selected with the BIC.

#<p>Models (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>): “-” = null, basic, “sub” = subset, “inv. sub” = inverse subset.</p>∧<p>Migraine characteristics: aura, pulsation, unipain ( = unilateral pain), sound ( = phonophobia), light ( = photophobia), duration of 4–72 hours ( = longdur), nausea, aggravation by physical activity ( = aggrphys), severity inhibits daily activities ( = inhibit), ≥6 attacks/year ( = freq).</p><p>“*” indicates models with significant LLR test p-values (<0.05) after adjustment for multiple hypothesis testing (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>).</p

Estimates (beta coefficients) for association in the WGHS from logistic models for each of the 12 candidate SNPs as predictors of migraine accompanied by aura or other characteristics (black bars), or not (gray bars).

<p>Significant associations are indicated with “*” (see also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#pgen.1004366.s005" target="_blank">Table S4</a>). Model selection results (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#pgen-1004366-t003" target="_blank">Tables 3</a> & <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#pgen-1004366-t004" target="_blank">4</a>) are indicated with outlines around each plot as follows: Non-null models selected using the BIC are indicated with a heavy red outline, while non-null models selected using the AIC are indicated with a thin black outline. “Subset” or “inverse subset” models (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>) are indicated with a solid outline, “basic” models are indicated with a dotted outline, and “general” models are indicated with a dashed outline. Migraine characteristics considered were aura, pulsating pain ( = pulsate), unilateral pain ( = unipain), phonophobia ( = sound), photophobia ( = light), duration of 4–72 hours ( = longdur), nausea, aggravation by physical activity ( = aggrphys), inhibition of daily activities ( = inhibit), ≥6 attacks/year ( = freq). The rightmost column (actmig) indicates association estimates for active migraineurs, irrespective of status for the characteristics (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>). The order of SNPs is derived from clustering as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#pgen.1004366.s001" target="_blank">Figure S1</a>. See also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004366#s4" target="_blank">Methods</a>.</p

Rezidivierende Infektionen: Pilze, Herpes, Bakterielle Vaginose

Diagnostic (ICD-9) and Procedural (CPT) codes used to generate predictor and outcome variables. (DOCX 17 kb

Flow-chart of inclusions, non-inclusions and exclusions. Neonates are ≤28 days and older children >28 days and less than 8 years.

<p>*ICT - Intensive Care Transport team positioned antenatally for premature births.</p

Supplemental material for The association between migraine and hospital readmission due to pain after surgery: A hospital registry study

<p>Supplemental material for The association between migraine and hospital readmission due to pain after surgery: A hospital registry study by Katharina Platzbecker, Megan Behua Zhang, Tobias Kurth, Maira Isabella Rudolph, Katharina Eikermann-Haerter, Rami Burstein, Matthias Eikermann and Timothy Houle in Cephalalgia</p

The influence of atropine of the change in heart rate during intubation of the two age sub-groups.

<p>The influence of atropine of the change in heart rate during intubation of the two age sub-groups.</p

Multivariable analysis of the change in heart rate during intubation following fall in peripheral oxygen saturation (SpO₂) and after the use of atropine (corrected by the propensity score [PS]). Neonates are ≤28 days and older children >28 days and less than 8 years.

<p>Multivariable analysis of the change in heart rate during intubation following fall in peripheral oxygen saturation (SpO₂) and after the use of atropine (corrected by the propensity score [PS]). Neonates are ≤28 days and older children >28 days and less than 8 years.</p