Changes in Sagittal Plane Kinematics and Kinetics after Distal Release of Medial Hamstrings in Cerebral Palsy

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Spasticity: orthopaedic perspectives

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Paediatric Patients with Bone Quality Issues & How to Correct the Problem

Pre-Meeting Course Program — Session 1published_or_final_versio

The immunomodulatory effect of silver nanoparticles is critical for promotion of tendon repair

Poster Session 1: abstract no. 486INTRODUCTION: Full recovery of tendon injury still remains difficult to achieve in modern medicine. Scarring and reduced mechanical properties of the repaired tendon are always the issues for tendon injury. Previously we demonstrated that local injection of silver nanoparticles (AgNPs) in a rat tendon rupture model successfully alleviated inflammation, improved collagen alignment and the tensile property of the repaired tendon at an early time point of 6 weeks [1]. In this study, we would like to investigate the mechanism behind. In the literatures, it was proven that there is a strong link between inflammation and tissue fibrosis in healing [2-6]. In tissue ...postprin

Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications

Footnote in article: Paper submitted as part of the 3rd European Conference on Microfluidics ... 2012We report a facile and robust microfluidic method to fabricate polymeric core-shell microspheres as delivery vehicles for biomedical applications. The characteristics of core-shell microspheres can be precisely and easily tuned by manipulating the microfluidic double emulsion templates. The addition of a shell can significantly improve the versatility as well as functionality of these microspheres as delivery vehicles. We demonstrate that the nature of the shell material plays an important role in the properties of the core-shell delivery vehicles. The release kinetics is significantly influenced by the material of the shell and other characteristics such as the thickness. For example, by adding a poly(lactic-co-glycolic acid) (PLGA) shell to an alginate core, the encapsulation efficiency is enhanced and undesired leakage of hydrophilic actives is prevented. By contrast, adding an alginate shell to PLGA core can lead to a reduction of the initial release rate, thus extending the release period of hydrophobic actives. Microfluidic fabrication enables the generation of precisely controlled core-shell microspheres with a narrow size distribution, which enables the investigation of the relationship between the release kinetics of these microspheres and their characteristics. The approach of using core-shell particles as delivery vehicles creates new opportunities to customize the release kinetics of active ingredients. © 2013 AIP Publishing LLC.published_or_final_versio

Droplet based microfluidic fabrication of designer microparticles for encapsulation applications

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Pitfalls in diagnosing septic arthritis in Hong Kong children: ten years' experience

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Septic arthritis caused by Brucella melitensis in urban Shenzhen, China: a case report

Abstract Introduction: Brucellosis is a systemic infectious disease which is still a challenging medical problem in rural areas such as northern China. It rarely occurs in urban areas such as Shenzhen in southern China. Osteoarticular involvements are frequently seen in brucellosis, and rarely is arthritis the only clinical presentation. We report a case of hip septic arthritis caused by Brucella melitensis in an urban area of Shenzhen, China. Case presentation: A 29-year-old Chinese woman, Han ethnical group presented to our hospital with left hip pain persisting for one month. She had a history of contact with goats one month before admission. Her clinical examination showed marked tenderness and limited movement of her left hip. Further imaging showed effusion of her left hip joint. Inflammatory markers including erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) were raised. Our clinical diagnosis was septic arthritis of the left hip. A left hip arthroscopy was performed and the culture was positive for Brucella melitensis. She returned to normal activity after completing a standard antibiotic regimen, including gentamicin at 120mg daily for 2 weeks, doxycycline at 100mg daily and rifampicin at 450mg for a total of 12 weeks. Conclusions: Brucellosis is endemic in some rural areas of China, but rare in urban areas such as Shenzhen in southern China. However, more cases will be expected in urban areas due to increasing migration within China. Physicians should consider brucellosis as one of the differential diagnosis of arthritis. Early surgical intervention is recommended to prevent further joint destruction.published_or_final_versio

The use of three-dimensional printing technology in orthopaedic surgery: A review

Three-dimensional (3-D) printing or additive manufacturing, an advanced technology that 3-D physical models are created, has been wildly applied in medical industries, including cardiothoracic surgery, cranio-maxillo-facial surgery and orthopaedic surgery. The physical models made by 3-D printing technology give surgeons a realistic impression of complex structures, allowing surgical planning and simulation before operations. In orthopaedic surgery, this technique is mainly applied in surgical planning especially revision and reconstructive surgeries, making patient-specific instruments or implants, and bone tissue engineering. This article reviews this technology and its application in orthopaedic surgery.published_or_final_versio