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The immunomodulatory effect of silver nanoparticles is critical for promotion of tendon repair

Abstract

Poster Session 1: abstract no. 486INTRODUCTION: Full recovery of tendon injury still remains difficult to achieve in modern medicine. Scarring and reduced mechanical properties of the repaired tendon are always the issues for tendon injury. Previously we demonstrated that local injection of silver nanoparticles (AgNPs) in a rat tendon rupture model successfully alleviated inflammation, improved collagen alignment and the tensile property of the repaired tendon at an early time point of 6 weeks [1]. In this study, we would like to investigate the mechanism behind. In the literatures, it was proven that there is a strong link between inflammation and tissue fibrosis in healing [2-6]. In tissue ...postprin

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