On the Kinetics of Body versus End Evaporation and Addition of Supramolecular Polymers

Although pathway-specific kinetic theories are fundamentally important to describe and understand reversible polymerisation kinetics, they come in principle at a cost of having a large number of system-specific parameters. Here, we construct a dynamical Landau theory to describe the kinetics of activated linear supramolecular self-assembly, which drastically reduces the number of parameters and still describes most of the interesting and generic behavior of the system in hand. This phenomenological approach hinges on the fact that if nucleated, the polymerisation transition resembles a phase transition. We are able to describe hysteresis, overshooting, undershooting and the existence of a lag time before polymerisation takes off, and pinpoint the conditions required for observing these types of phenomenon in the assembly and disassembly kinetics. We argue that the phenomenological kinetic parameter in our theory is a pathway controller, i.e., it controls the relative weights of the molecular pathways through which self-assembly takes place

Cost Based Optimization of Job Allocation in Computational Grids

Computational grids are distributed systems composed of heterogeneous computing resources which are distributed geographically and administratively. These highly scalable systems are designed to meet the large computational demands of many users from scientific and business orientations. Grid computing is a powerful concept, its chief appeal being the ability to make sure all of a resource’s computing power is used. In a grid world, the idle time of hundreds or thousands of resources could be harnessed and rented out to anyone who needed a massive infusion of processing power. First, the architecture of a grid system is presented. The design gives a mathematical model of the grid system for efficiently allocating the grids resources. The challenges faced for optimal job allocation motivate the exploration in optimizing grid resource allocations. We have extensively surveyed the current state of art in this area. A grid server coordinates the job allocation for the grid users and helps to select the best resources for a job among different possible resource offers with the best prices offered. Interaction between grid users and the resources require a mediator that uses different paradigm to communicate the needs of the two parties in terms of performance requirements, timing constraints, price charged etc. A game theoretic bargaining approach is studied to agree upon standard prices. We have implemented various job allocation schemes in computational grids based on the mathematical modeling of the grid system and bargaining protocol with the objective function of optimizing the cost. The performance of the schemes have been analyzed and compared. A new model for job allocation in computational grids has been proposed, for job allocation based on the clustering of resources

Ayurveda Perspective of Rasamanikya and its Role in Skin Disorders: A Review

Rasamanikya is drug used commonly in Ayurveda practice for various therapeutic purposes. Rasamanikya made out of Shuddha Haratala and due to the Manikya (Ruby) colour of formulation it is termed as Rasamanikya. Rasamanikya can be prepared by classical Abhraka Patra method and Sharava Samputa method, etc. It is recommended for the management of Kustha Roga, Shwasa, Phirana Roga, Vicharchika, Bhaganadara and Vatarakta. The classical descriptions on Rasamanikya establish it as drug of choice for skin related health ailments due to its Ayurveda properties and health benefits. Therefore present article reviewed Ayurveda perspective of Rasamanikya and its role in skin disorders.       Keywords: Ayurveda, Rasamanikya, Skin, Disorders, Kustha Rog

An experimental study on micro-structural and geotechnical characteristics of expansive clay mixed with EPS granules

© 2020 Pavement structures constructed on the expansive soil subgrade experience a higher upward pressure compared to any other subgrade material. The upward pressure is caused due to high swelling and shrinkage characteristics of expansive clay soil. The present study has investigated and identified the mechanisms by which a remolded expansive soil can be modified to reduce the upward pressure and swelling (heave). To achieve this, a lightweight, environmentally friendly, and high pressure resistive expanded polystyrene (EPS) granules have been used with expansive soil s from three different locations of Madhya Pradesh state, India. The study has been performed to understand the swelling and strength characteristics of soil with and without the use of EPS (density = 21.6 kg/m3) as per ASTM specifications. The chemical and microstructural components of the expansive soil were investigated using autotuned total reflectance Fourier transform infrared (ATR-FTIR), X-ray diffraction (XRD), and scanning electron microscope (SEM). Several laboratory experiments, including optimum moisture content, maximum dry unit weight, grain-size distribution, liquid limit, plastic limit, shrinkage limit, free swell index, unconfined compressive strength, and pressure swelling tests were carried out on the statically compacted expansive clay soil specimen with and without EPS (0.25%, 0.50%, 1.00%). The maximum addition of EPS was considered as 1% as the very high expansion was observed, and beyond this, further addition of EPS was not feasible. The results show that the swelling pressure, expansion percentage, and time rate of swell decrease, whereas the unconfined compressive strength (UCS) increases with the addition of EPS. The inclusion of EPS in expansive clay soil exponentially reduced the heave and the upward pressure, whereas the maximum UCS was observed at 0.5%

UNDERSTANDING LASUNA AS RASAYANA - A CRITICAL REVIEW

The Medicinal use of Garlic is not new to the world today. Garlic plays important role in daily diet and also helps in maintaining good health thats why it is widely suggested by physicians. Lasuna is a most potent herb used in many conditions mainly used as a Rasayana in Vatavyadhi, Amavata etc. The essential chemical components of Garlic are helpful in daily routine for making physic fit and it acts over Hypercholesterolemia. The wide range of Garlic, health benefits come mainly from its main ingredient, Allicine. This widely researched component of garlic is highly therapeutic and is used in various drugs and pharmaceutics. Many Acharyas used this potent herb in many formulations like Lashoonadi vati, Lashoona ksheera paka etc. Rejuvenation therapy enhances the energy and the person's mental and physical capabilities. A number of studies suggest that rejuvenation therapy is effective in improving the skin complexion, texture, in modulating the voice and in increasing the sensing capacity of the sense organs. Rasayana is that which provides optimum quality of the bodily tissues due to which it provides both mental and physical health, prevents ageing and disease, thus enables to live for a longer period of youthfulness. In current article importance of Garlic is shown as Rasyana, as its indication and properties of Garlic as per Ayurveda suggest its work as Rasayana

Candoia: a platform for building and sharing mining software repositories tools as apps

We propose Candoia, a novel platform and ecosystem for building and sharing Mining Software Repositories (MSR) tools. Using Candoia, MSR tools are built as apps and Candoia ecosystem, acting as an appstore, allows effective sharing. Candoia platform provides, data extraction tools for curating custom datasets for user projects, and data abstractions for enabling uniform access to MSR artifacts from disparate sources, which makes apps portable and adoptable across diverse software project settings of MSR researchers and practitioners. The structured design of a Candoia app and the languages selected for building various components of a Candoia app promotes easy customization. To evaluate Candoia we have built over two dozen MSR apps for analyzing bugs, software evolution, project management aspects, and source code and programming practices showing the applicability of the platform for building a variety of MSR apps. For testing portability of apps across diverse project settings, we tested the apps using ten popular project repositories, such as Apache Tomcat, JUnit, Node.js, etc, and found that apps required no changes to be portable. We performed a user study to test customizability and we found that five of eight Candoia users found it very easy to customize an existing app. Candoia is available for download

Stochastic Lag Time in Nucleated Linear Self-Assembly

Protein aggregation is of great importance in biology, e.g., in amyloid fibrillation. The aggregation processes that occur at the cellular scale must be highly stochastic in nature because of the statistical number fluctuations that arise on account of the small system size at the cellular scale. We study the nucleated reversible self-assembly of monomeric building blocks into polymer-like aggregates using the method of kinetic Monte Carlo. Kinetic Monte Carlo, being inherently stochastic, allows us to study the impact of fluctuations on the polymerisation reactions. One of the most important characteristic features in this kind of problem is the existence of a lag phase before self-assembly takes off, which is what we focus attention on. We study the associated lag time as a function of the system size and kinetic pathway. We find that the leading order stochastic contribution to the lag time before polymerisation commences is inversely proportional to the system volume for large-enough system size for all nine reaction pathways tested. Finite-size corrections to this do depend on the kinetic pathway

Acceptance of COVID-19 Vaccination Among Health Care Workers in India

Background: The coronavirus disease 2019 has been spread almost all over the world in the last two years, including in India. Vaccines are a critical tool in the battle against COVID-19, and India has flagged the largest vaccination drive on 16 January 2021. Although public acceptance was varying, which can lead to non-acceptance. Aim & Objective: To estimate an acceptance of the COVID-19 vaccine and its associated factors. Settings and Design: An analytical cross-sectional study among health care workers in India   Methods & Material: It was conducted using a validated, self-administrated online survey questionnaire, and data were analyzed using SPSS 23 version. The outcome variable was healthcare workers’ acceptance of a COVID-19 vaccine. Results: A total of 450 HCWs participated, including 205(45.6%) women and 245(54.4%) men. A total of 270 (60%) subjects will accept vaccines, while 33.3% were unwilling to accept and wait for vaccines. Male gender (OR=3.14), being married and experienced (OR=11.49), vaccine effectiveness (OR=6.4), vaccine safety (OR=3.4), and past history (OR=2.28) were significantly associated. On applying logistic regression for associated factors, gender (B= -1.145, S.E.= 0.200, Wald 32.748), being married (B= -1.482, S.E.= 0.216, Wald 46.937), for experienced (B= -0.865, S.E.= 0.200, effectiveness (B= -1.856, S.E.= 0.245, Wald 57.431), Safety (B= -1.224, S.E.= 0.202, Wald 36.633) and past history (B= -0.357, S.E.= 0.248, Wald 2.071) found significant. Recommendation: Proper information is crucial and healthcare workers’ attitudes about vaccines are an important factor for acceptance and recommendation of the vaccine to the public for population-wide coverage

Border Security System

This paper presents an idea to secure the border in a simple and more reliable way, The proposed idea has a simple design and has a very high range , it covers a very large border area securing the border area from illegal entries, smuggling ,illegal movement of weapon without much involvement of security forces near border. Afteranalysing the previous attack in our country and the number of accidents happening each year, it is evident that in most of the cases the security force are unaware of the entry of these terrorist hence in order to protect our nation from such attacks and terrorist activity there is a need to implement a security system which will be smart enough to detect these activity and give proper information about each and every activity happening near the border. In this paper, we propose building a security system that can be implemented by using advance feature like obstacle detection, obstacle identification, distance sensing and activity tracking, and quick communication between the source area and control room . If obstacle enters the border it automatically detects the obstacle give warnings and send the record of activity to control room. Also it eliminates the enemy in more efficient and better way