Perturbation resilience for the facility location problem

We analyze a simple local search heuristic for the facility location problem using the notion of perturbation resilience: an instance is γ-perturbation resilient if all costs can be perturbed by a factor of γ without changing the optimal solution. We prove that local search for FLP succeeds in finding the optimal solution for γ-perturbation resilient instances for γ≥3, and we show that this is tight

Themadag 'Management bodemstructuur', 14 juni 1990

IMAG NRLO congres bodemonderzoe

Targeted therapies in head and neck cancer

Dongen, G.A.M.S. van [Promotor]Leemans, C.R. [Promotor]Bree, R. de [Copromotor

Electroporation Therapy in Soft Tissue Sarcoma: A Potentially Effective Novel Treatment

Purpose. Examination of the potential of electroporation therapy (EPT) in a patient with metastatic soft tissue sarcoma. Patient. A 24-year-old male who underwent extensive resection and postoperative radiotherapy for a malignant peripheral nerve sheath tumor in the right infratemporal fossa with intracranial extension and invasion of the maxillary sinus and mandible had a recurrence in the scar of his craniotomy for which he was initially treated with doxorubicin. After discontinuation of doxorubicin he developed a metastatic mass at the same site for which he was treated with electroporation therapy. Method. The subcutaneous metastasis was infiltrated with bleomycin and electroporated. Results. Gradually the tumor became increasingly necrotic and demarcated from surrounding tissue. After 10 weeks no tumor was seen anymore. The wound healed secondarily. Discussion. Intralesional bleomycin followed by EPT is potentially effective, well tolerated, and easy to perform in well accessible soft tissue sarcoma sites

Grote impact verbod neonicotinoïden

Dringend alternatieven nodig voor de beheersing van vergelingsziekte in de suikerbietenteelt. De ziekte kan de opbrengst ernstig schaden