Reliability Analysis of Metro Door System Based on Fuzzy Multi-State Bayesian Network

Considering the shortcomings of the fault tree analysis (FTA) method in the reliability analysis of metro door systems, Bayesian network (BN) and fuzzy theory were introduced to establish the failure probability model of a metro door system. A fault tree of the metro door system was established based on the structure of the metro door, the operation data record and the practical experience of relevant engineers. The BN of the metro door system was constructed based on the fault tree. For the problem that the prior probabilities of root nodes with missing data were unavailable, fuzzy theory was introduced to convert the expert language values on these missing data nodes to corresponding prior probabilities, which were substituted into the BN along with the root nodes whose prior probabilities were obtained from the operation fault data to calculate the leaf node probability. Cause analysis of the metro door system was performed with bi-directional reasoning of BN, which provided a way to find the key factors that caused door faults and the metro door system fault probabilities

Circ_0008234 regulates the biological process of gallbladder carcinoma by targeting the miR-204-5p/FGFR2 axis

Background. Gallbladder carcinoma (GBC) is a common cancer disease with high mortality. Circular RNA_0008234 (circ_0008234) has been shown to play a key role in many tumors, including GBC. However, the function between circ_0008234 and microRNA-204-5p (miR-204-5p) in the progression of GBC has not been clarified. Methods. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expressions of circ_0008234, miR-204-5p and fibroblast growth factor receptor-2 (FGFR2) in GBC cells and tissues. Western blot was used to detect the expression of relative proteins. Cell proliferation, apoptosis, invasion and migration were detected by 3-(4, 5-dimethylthiazol2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, thymidine analog 5-ethynyl-2’-deoxyuridine (EdU) assay, flow cytometry, transwell assay and wound healing assay. Mechanically, the interaction of miR-2045p with circ_0008234/FGFR2 was notarized by dualluciferase reporter assay. A xenotransplantation model was established to study the role of circ_0008234 in vivo. Results. Circ_0008234 and FGFR2 were highly expressed in GBC tissues and cells. Silencing circ_0008234 down-regulated cell proliferation, migration and invasion of NOZ and SGC-996 cells, while miR-204-5p inhibitors reversed these effects. In addition, overexpression of FGFR2 restored the cell malignant behavior of GBC cells inhibited by miR-2045p mimic. Animal experiments confirmed the anti-tumor effect of silenced circ_0008234 in vivo. Conclusion: Circ_0008234 mediated GBC via the miR-204-5p/FGFR2 axis, providing a novel targeted therapy for gallbladder carcinom

Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study

Table S1. The nutrient composition, energy ratio and fatty acid profiles of experimental diets. Table S2. Primers used in this study. Figure S3. The weekly body weight change of experiment animals. Table S4. Differentially expressed genes between WD group and CON group. Table S5. Differentially expressed genes between FOH group and WD group. Table S6. Upregulated DEGs (FOH vs. WD) implicated in the enrichedgene ontology processes. Table S7. Downregulated DEGs (FOH vs. WD) implicated in the enrichedgene ontology processes. (ZIP 236 kb

Metrics in Master Planning Low Impact Development for Grand Rapids Michigan

Planners, designers, citizens, and governmental agencies are interested in measuring and assessing urban design treatments that are environmentally sensitive across numerous environmental design issues such as stormwater, adapting to climate change, wildlife suitability, visual quality, and maintaining soil productivity. This chapter examines a case study in the Grand Rapids Michigan, exploring design ideas for the extension of a medical campus and adjoining areas. The results of the case study present newly derived equations to assess soil productivity. The results of the soil equation development indicate that the soil productivity of an area has two primary dimensions, forming an annual plant preference cluster, a woody plant preference cluster, and a wetland plant preference cluster, where each soil setting requires a different soil profile. The equations explain between 90 and 97% of the variance and are definitive (p-value<.001). The environmental variables examined in the study, including the soil productivity, indicate that the developed master plan for the site is significantly better than traditional approaches and the existing site characteristics (p-value < 0.05)

2-(1H-Benzotriazol-1-yl)-1-(2-chloro­benzo­yl)ethyl 4-methyl­benzoate

In the mol­ecule of the title compound, C23H18ClN3O3, the essentially planar benzotriazole ring makes dihedral angles of 52.93 (1) and 85.21 (1)°, respectively, with the chloro­phenyl and tolyl rings. The crystal packing is stabilized by π–π [centroid-to-centroid distance 3.830 (2) Å, interplanar distance 3.705 Å, slippage 0.968 Å]; C—H⋯π⋯tolyl ring inter­actions are also present

Cyclic nonlinear interferometry with entangled non-Gaussian spin states

We propose an efficient nonlinear readout scheme for entangled non-Gaussian spin states (ENGSs) based on the intrinsic quasi-cyclic dynamics of interacting spin-1/2 systems. We focus on two well-known spin models of twist-and-turn (TNT) and two-axis-counter-twisting (TACT), where ENGS can be generated by spin dynamics starting from unstable fixed points. In the TNT model, non-Gaussian probe state evolves directly back to the vicinity of initial state during the subsequent time-forward evolution for path recombining, accompanied by quantum magnification of encoded signal and refocusing of the associated quantum noise. Based on low-order moment measurement, we find the optimal metrological gain nearly saturates the quantum Cramer-Rao bound (QCRB) and follows the Heisenberg scaling. For the TACT case, the QCRB can also be nearly approached when the state converges to either of the two unstable fixed points, respectively corresponding to the initial state or its orthogonal coherent state. The latter case goes beyond previous studies where tracing back to or crossing the initial states is mostly considered. The present protocol does not require time-reversal as in typical nonlinear interferometries, and it also avoids complicated measurement of nonlinear observables or full probability distributions. The operational approach we discuss presents a practical way for realizing high-precision and detection-noise-robust quantum metrology with ENGS.Comment: 10 pages, 6 figure

Special Libraries, November 1922

Volume 13, Issue 9https://scholarworks.sjsu.edu/sla_sl_1922/1008/thumbnail.jp