Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime

The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine. Keywords: N-Benzyl piperidin 4-one oxime, meristamatic cells, mitotic index

Synthesis, characterization and thrombolytic activity of n-benzyl piperidin 4-one phenyl hydrazone

The aim of this study was to synthesize, characterization and thrombolytic activity of    N-Benzyl piperidin 4-one phenyl hydrazone derivative. Check the purity of all the synthesized compounds using thin layer chromatography. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to thrombolytic activity. The thrombolytic activity was observed in 2 different concentrations of N-Benzyl piperidin 4-one phenyl hydrazone. Our findings support the reported therapeutic use of this compound as a thrombolytic agent in the Indian system of medicine. Keywords: N-Benzyl piperidin 4-one phenyl hydrazone, thrombolytic activity, streptokinase

Biology and management of mealybug, Paracoccus marginatus Williams and Granara de Willink on Jatropha curcas L.

Jatropha cultivation is gaining importance as potential source of biofuel. Recently Paracoccus marginatus has been found to cause serious damage on Jatropha. Studies on the biology and management of P. marginatus at GKVK, Bangalore revealed that the females had three nymphal instars without any pupal stage, while the male had three nymphal instars besides, pre-pupal and pupal stages. The total nymphal period for female ranged from 14 to 21 days, (mean- 17.32±1.6 days) while for male the range was 16 to 23 days, (mean- 18.9±1.3 days). Bisexual and parthenogenetic modes of reproduction were observed. The fecundity of the female mealybug ranged from 248 to 967, with an average of 618.9±19 eggs. Evaluation of insecticides revealed that during first spray and second spray, mean per cent reduction of mealy bug population was highest in profenophos 0.05% (68.05 and 79.35) followed by buprofezin 0.025% (63.61 and 72.69). Least per cent reduction of mealy bug was observed in the NSKE 5% (17.94 and 25.77) treatment

T cell phenotypes in COVID-19 - a living review

COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of activation and exhaustion. However, antigen-specific T cell responses are emerging as a crucial mechanism for both clearance of the virus and as the most likely route to long-lasting immune memory that would protect against re-infection. Therefore, T cell responses are also of considerable interest in vaccine development. Furthermore, persistent alterations in T cell subset composition and function post-infection have important implications for patients’ long-term immune function. In this review, we examine T cell phenotypes, including those of innate T cells, in both peripheral blood and lungs, and consider how key markers of activation and exhaustion correlate with, and may be able to predict, disease severity. We focus on SARS-CoV-2-specific T cells to elucidate markers that may indicate formation of antigen-specific T cell memory. We also examine peripheral T cell phenotypes in recovery and the likelihood of long-lasting immune disruption. Finally, we discuss T cell phenotypes in the lung as important drivers of both virus clearance and tissue damage. As our knowledge of the adaptive immune response to COVID-19 rapidly evolves, it has become clear that while some areas of the T cell response have been investigated in some detail, others, such as the T cell response in children remain largely unexplored. Therefore, this review will also highlight areas where T cell phenotypes require urgent characterisation

The role and uses of antibodies in COVID-19 infections: a living review

Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity

Real-Time Implementation of Locality Sensitive Hashing Using NI WSN and LabVIEW for Outlier Detection in Wireless Sensor Networks

Abstract Outlier detection is one of the major challenges in wireless sensor networks. To the best of our knowledge, not many have evaluated the performance of outlier detection algorithms in real time. This paper proposes a real time hardware implementation of outlier detection using locality sensitive hashing algorithm for temperature data and evaluated both in indoor and outdoor environments. NI WSN 3202 programmable nodes and NI 9792 programmable gateway is used for hardware implementation of the algorithm and LabVIEW TM software is used for programming the nodes. The LSH technique detects outliers based on the threshold value. Hence the outlier detection accuracy and precision are analyzed for various threshold values and the optimal threshold value is selected

Cutaneous manifestations of internal malignancy

Background: Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases) or nonspecific lesions. Aims: The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy. Materials and Methods: 750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC) and marker studies. Results: Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93%) patients. Conclusion: Cutaneous metastases (specific lesions) were seen in 20 patients (2.66%): contiguous in 6 (0.8%), and non-contiguous in 14 (1.86%). Nonspecific skin changes were seen in 32 patients (4.26%). None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis

OLMSTED SYNDROME: REPORT OF TWO CASES

Olmsted syndrome is an uncommon genetic disorder with symmetrical, diffuse, transgredient, mutilating palmoplantar keratoderma and periorificial hyperkeratosis. Olmsted syndrome in a female patient is particularly rare, and we report two unrelated female patients of Olmsted syndrome, who presented with perioral hyperkeratosis and palmoplantar keratoderma. One of our patients also had woolly hair from birth and flexion contracture of a digit, while the other had pseudoainhum. There was no cardiac involvement. Hence, the diagnosis of Olmsted syndrome was made