A multicentre, randomised, parallel‐group, double‐blind, vehicle‐controlled and open‐label, active‐controlled study (versus amorolfine 5%), to evaluate the efficacy and safety of terbinafine 10% nail lacquer in the treatment of onychomycosis

Background: Onychomycosis is a difficult-to-treat fungal nail infection whose treatment can involve systemic or topical antifungal approaches. Objectives: To assess the efficacy and safety of terbinafine 10% nail lacquer in distal-lateral subungual onychomycosis (DLSO). Patients/methods: Patients with mild-to-moderate DLSO were randomised (3:3:1) to receive double-blind topical terbinafine 10% (n = 406) or its vehicle (n = 410) administered once daily for 4 weeks and then once weekly for 44 weeks, or open-label topical amorolfine 5% (n = 137) for 48 weeks, with a 12-week follow-up period. The primary efficacy endpoint, complete cure rate at Week 60, was a composite of negative potassium hydroxide (KOH) microscopy, negative culture for dermatophytes and no residual clinical involvement of the target big toenail. Results: Complete cure rates at Week 60 in the terbinafine, vehicle and amorolfine groups were 5.67%, 2.20% and 2.92%, respectively (odds ratio (OR) vs vehicle = 2.68; 95% confidence intervals (CI): 1.22-5.86; p = .0138). Statistically significant differences in responder (negative KOH and negative culture and ≤10% residual clinical involvement) and mycological cure rates (negative KOH and negative culture) at Week 60 were obtained between terbinafine and vehicle. Terbinafine was well-tolerated with no systemic adverse reactions identified; the most common topical adverse reactions were erythema and skin irritation. Conclusions: Terbinafine 10% nail lacquer was an effective treatment for mild-to-moderate onychomycosis improving both clinical and mycological criteria compared with vehicle. Furthermore, there may be some benefits compared to the currently available topical agent, amorolfine 5%. Treatment was well-tolerated and safe

Foro Valenciano para la abolición de la prostitución: medidas y propuestas para su erradicación

El informe "Foro valenciano para la abolición de la prostitución: medidas y propuestas para su erradicación" recoge las aportaciones y el trabajo realizado por las personas Expertas que han colaborado en el marco de la RESOLUCIÓN de 25 de febrero de 2021, de la consellera de Justicia, Interior y Administración Pública por la que se crea y regula la composición y funcionamiento del Foro Valenciano para la abolición de la prostitución. Entre las aportaciones recogidas y las medidas articuladas se encuentran las realizadas por la profesora de Derecho Constitucional de la UA, Dra. Concepción Torres, integradas en el Panel de personas Expertas del Grupo 2. Propuestas de reformas jurídico-administrativa y penal (Anexo I).Conselleria de Justicia, Interior y Administración Pública de la Generalitat Valencian