12 research outputs found
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Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal
Urinary type IV collagen excretion in the Japanese general population without diabetes
Urinary type IV collagen (U-Col4) and albumin excretion is evaluated to monitor the development of diabetic kidney disease. However, U-Col4 excretion in the general population without diabetes has not yet been fully elucidated. In this study, 1067 participants without diabetes and with urinary albumin-creatinine ratio <300 mg/gCr (normo- or microalbuminuria) who underwent an annual health examination in 2004 were enrolled and observed for 5 years. They were divided according to the amount of U-Col4 or urinary albumin excreted. The decline in estimated glomerular filtration rate (eGFR) was calculated. In participants with eGFR ≥80 mL/min, abnormal U-Col4 excretion was indicated as a significant independent risk factor for 10% eGFR change per year, which is one of the prognostic factors for the development of end-stage kidney disease. Moreover, in contrast to urinary albumin excretion, U-Col4 excretion was not related to age or kidney function, suggesting that some individuals with abnormal U-Col4 excretion can have an independent hidden risk for the development of kidney dysfunction. In conclusion, it is important to measure U-Col4 excretion in the general population without diabetes to determine changes in renal features in every individual and help detect future complications such as diabetic kidney disease. If U-Col4 excretion is abnormal, kidney manifestation should be carefully followed up, even if the kidney function and urinalysis findings are normal
Distribution of participants with abnormal urinary type IV collagen-creatinine ratio or microalbuminuria in each eGFR group.
<p>Distribution of participants with abnormal urinary type IV collagen-creatinine ratio or microalbuminuria in each eGFR group.</p
Decline in eGFR in participants without diabetes with normo- or microalbuminuria.
<p>Participants with the highest eGFR (≥80 mL/min) had a faster decline in eGFR than those with eGFR <68.1 mL/min. Num.: Number. 95%CI: 95% confidence interval. *<i>P</i> <0.01.</p
Characteristics of participants with or without 10% of eGFR change per year in each group.
<p>Characteristics of participants with or without 10% of eGFR change per year in each group.</p
Characteristics of participants with or without 10% of eGFR change per year in each group.
<p>Characteristics of participants with or without 10% of eGFR change per year in each group.</p
Odds ratios of urinary type IV collagen-creatinine ratio (U-Col4CR) and urinary albumin-creatinine ratio (ACR) for 10% of eGFR change per year in participants with normoalbuminuria only.
<p>Odds ratios of urinary type IV collagen-creatinine ratio (U-Col4CR) and urinary albumin-creatinine ratio (ACR) for 10% of eGFR change per year in participants with normoalbuminuria only.</p
Kaplan-Meier curves to evaluate the prognostic value of urinary type IV collagen-creatinine ratio (U-Col4CR) or urinary albumin-creatinine ratio (ACR) for 10% eGFR change per year.
<p>A: Abnormal urinary type IV collagen-creatinine ratio. N: Normal urinary type IV collagen-creatinine ratio. M: Microalbuminuria. L: Normoalbuminuria.</p