Inverse comorbidity: the power of paradox in the advancement of science

Research on comorbidity and multimorbidity is finally receiving the attention it deserves, particularly considering the magnitude and impact they have on health and the delivery of healthcare [1,2]. Numerous studies have demonstrated that individuals with Down’s syndrome, Parkinson’s disease, schizophrenia, diabetes, anorexia nervosa, Alzheimer’s disease, allergy related diseases, multiple sclerosis or Huntington’s disease (among other health problems) are protected against many forms of cancer, including solid tumors, smoking-related tumors and prostate cancer. This apparent anti-cancer effect, which we have termed inverse cancer comorbidity, has been observed in many serious CNS and immune disorders, and is the subject of active research [3–5].Journal of Comorbidity 2013;3(1):1–3

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015

Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015

FINDINGS: Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0-42·8) in 1990 to 53·7 (52·2-55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015

BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures

Pla d'acció en salut mental, drogodependències i conductes addictives. Comunitat Valenciana 2023-2026

L'exposició permanent i acumulativa a situacions adverses globals està descompensant a persones amb malaltia mental però també ens avisa que qualsevol pot aconseguir la condició de persona depressiva, addicta, bevedora, angoixada, amb deterioració cognitiva o amb intenció de #morir. Davant aquesta preocupació, La Generalitat Valenciana i la Universitat de València arriben a un acord de col·laboració per a l'elaboració del Pla d'Acció en Salut Mental, Drogodependències i Conductes Addictives de la Comunitat Valenciana (2023-2026) a través d'un procés deliberatiu i participatiu en el qual s'ha atorgat un paper protagonista a la ciutadania. El resultat d'aquest pla són 8 grans accions que s'han definit a partir del resultat de les dues grans fases del procés: la Convenció Ciutadana sobre Salut Mental i la implicació directa de 148 agents clau en la recollida de propostes.The permanent and cumulative exposure to adverse global situations is decompensating people with mental illness, but it also warns us that anyone can become depressed, addicted, a drinker, anguished, with cognitive impairment or with the intention of dying. Given this concern, the Generalitat Valenciana and the University of Valencia reach a collaboration agreement for the preparation of the Action Plan on Mental Health, Drug Addiction and Addictive Behaviours of the Valencian Community (2023-2026) through a deliberative and participatory process in which citizens have a leading role. The result of this plan are 8 major actions that have been defined based on the result of the two major phases of the process: the Citizen Convention on Mental Health and the direct involvement of 148 key agents in the collection of proposals

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.

BACKGROUND: In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030. We provide an analysis of 33 health-related SDG indicators based on the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015

Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015

Plan de acción en salud mental, drogodependencias y conductas adictivas. Comunitat Valenciana 2023-2026

La exposición permanente y acumulativa a situaciones adversas globales está descompensando a personas con enfermedad mental pero también nos avisa que cualquiera puede alcanzar la condición de persona depresiva, adicta, bebedora, angustiada, con deterioro cognitivo o con intención de morirse. Ante esta preocupación, La Generalitat Valenciana y la Universidad de Valencia llegan a un acuerdo de colaboración para la elaboración del Plan de Acción en Salud Mental, Drogodependencias y Conductas Adictivas de la Comunidad Valenciana (2023-2026) a través de un proceso deliberativo y participativo en el que se ha otorgado un papel protagonista a la ciudadanía. El resultado de este plan son 8 grandes acciones que se han definido a partir del resultado de las dos grandes fases del proceso: la Convención Ciudadana sobre Salud Mental y la implicación directa de 148 agentes clave en la recogida de propuestas.The permanent and cumulative exposure to adverse global situations is decompensating people with mental illness, but it also warns us that anyone can become depressed, addicted, a drinker, anguished, with cognitive impairment or with the intention of dying. Given this concern, the Generalitat Valenciana and the University of Valencia reach a collaboration agreement for the preparation of the Action Plan on Mental Health, Drug Addiction and Addictive Behaviours of the Valencian Community (2023-2026) through a deliberative and participatory process in which citizens have a leading role. The result of this plan are 8 major actions that have been defined based on the result of the two major phases of the process: the Citizen Convention on Mental Health and the direct involvement of 148 key agents in the collection of proposals

Aproximación psicopatológica a El Quijote (según la nosología psiquiátrica actual).

Se analiza la psicopatología de Don Quijote y se revisan los estudios previos sobre el personaje, tanto desde la perspectiva médica como la literaria. Considerando el enfoque de la nosología psiquiátrica actual, Don Quijote cumpliría criterios para un Trastorno Delirante y esto se argumenta en base a la génesis del delirio, la sintomatología y los rasgos formales del delirio. Asimismo, se propone el diagnóstico de Trastorno Psicótico Compartido para la pareja protagonista (Don Quijote y Sancho