If not for profit, for what and how? Interuniversity Attraction Pole (IAP) on Social Enterprise (SOCENT) 2012-2017 Developing a Model of Social Entrepreneurship: A Grounded Study Approach

Abstract Abstract Abstract Abstract Within the past decade, much has been written on the topic of social entrepreneurship. However, the extant social entrepreneurship literature is predominantly either conceptua

METHOD AND SYSTEM FOR CONTROLLED INFORMATION DISCLOSURE BASED ON USER CONTEXT USING PRINCIPLES OF JUST-IN-TIME AND JUST-ENOUGH-ACCESS

The present disclosure discloses a system and method to controlled information disclosure based on user context using principles of Just-In-Time and Just-Enough-Access, during package transportation. The system includes a unique identifier generator module for receiving transportation information, associated with a package, and generates a machine-readable unique identifier. The generated unique identifier is stored in a database and placed on the package. Upon receiving the package at the shipper sites, the unique identifier on the package is scanned using a scanning device with a GPS module and the information is provided to a computing unit, for computing and retrieving information about the next location. Finally, after scanning the unique identifier, at a final location at the time of delivery, the computing unit may invalidate the unique identifier, to prevent unnecessary information reveal about the recipient/sender. Thus, the security problems that arise due to unauthorised information access are eliminated

Limousine Service Management: Capacity Planning with Predictive Analytics and Optimization

The limousine service in luxury hotels is an integral component of the whole customer journey in the hospitality industry. One of the largest hotels in Singapore manages a fleet of both in-house and outsourced vehicles around the clock, serving 9000 trips per month on average. The need for vehicles may scale up rapidly, especially during special events and festive periods in the country. The excess demand is met by having additional outsourced vehicles on standby, incurring millions of dollars of additional expenses per year for the hotel. Determining the required number of limousines by hour of the day is a challenging service capacity planning problem. In this paper, a recent transformational journey to manage this problem in the hotel is introduced, driving up to S\$3.2 million of savings per year with improved service level. The approach builds on widely available open-source statistical and spreadsheet optimization tools, along with robotic process automation, to optimize the schedule of its fleet of limousines and drivers, and to support decision-making for planners/controllers to drive sustained business value

Association of Caucasian-identified variants with colorectal cancer risk in Singapore Chinese

Background: Genome-wide association studies (GWAS) in Caucasians have identified fourteen index single nucleotide polymorphisms (iSNPs) that influence colorectal cancer (CRC) risk. Methods: We investigated the role of eleven iSNPs or surrogate SNPs (sSNPs), in high linkage disequilibrium (LD, r2≥0.8) and within 100 kb vicinity of iSNPs, in 2,000 age- and gender-matched Singapore Chinese (SCH) cases and controls. Results: Only iSNP rs6983267 at 8q24.21 and sSNPs rs6695584, rs11986063, rs3087967, rs2059254, and rs7226855 at 1q41, 8q23.3, 11q23.1, 16q22.1 and 18q21.1 respectively showed evidence of association with CRC risk, with odds ratios (OR) ranging from 1.13 to 1.40. sSNP rs827401 at 10p14 was associated with rectal cancer risk (OR = 0.74, 95% CI 0.63-0.88) but not disease prognosis (OR = 0.91, 95% CI 0.69-1.20). Interestingly, sSNP rs3087967 at 11q23.1 was associated with CRC risk in men (OR = 1.34, 95% CI 1.14-1.58) but not women (OR = 1.07, 95% CI: 0.88-1.29), suggesting a gender-specific role. Half of the Caucasian-identified variants, including the recently fine-mapped BMP pathway loci, BMP4, GREM1, BMP2 and LAMA 5, did not show any evidence for association with CRC in SCH (OR ~1; p-value >0.1). Comparing the results of this study with that of the Northern and Hong Kong Chinese, only variants at chromosomes 8q24.21, 10p14, 11q23.1 and 18q21.1 were replicated in at least two out of the three Chinese studies. Conclusions: The contrasting results between Caucasians and Chinese could be due to different LD patterns and allelic frequencies or genetic heterogeneity. The results suggest that additional common variants contributing to CRC predisposition remained to be identified. © 2012 Thean et al

Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain

<p>Abstract</p> <p>Background</p> <p>Morphine consumption can vary widely between individuals even for identical surgical procedures. As mu-opioid receptor (OPRM1) is known to modulate pain perception and mediate the analgesic effects of opioid compounds in the central nervous system, we examined the influence of two OPRM polymorphisms on acute post-operative pain and morphine usage in women undergoing elective caesarean delivery.</p> <p>Results</p> <p>Data on self-reported pain scores and amount of total morphine use according to patient-controlled analgesia were collected from 994 women from the three main ethnic groups in Singapore. We found statistically significant association of the OPRM 118A>G with self-administered morphine during the first 24-hour postoperative period both in terms of total morphine (p = 1.7 × 10^-5) and weight-adjusted morphine (p = 6.6 × 10^-5). There was also significant association of this OPRM variant and time-averaged self-rated pain scores (p = 0.024). OPRM 118G homozygotes used more morphine and reported higher pain scores than 118A carriers. Other factors which influenced pain score and morphine usage include ethnicity, age and paying class.</p> <p>Conclusion</p> <p>Our results suggest that ethnicity and OPRM 118A>G genotype are independent and significant contributors to variation in pain perception and postoperative morphine use in patients undergoing cesarean delivery.</p

Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells

10.1186/1749-8546-6-4Chinese Medicine6