Knowledge management: Using a knowledge requirements framework to enhance UK health sector supply chains

The gaps of mismatch both knowledge and understanding of beneficiaries and solution providers at the initial stage of developing projects have led to the failures of many projects including supply chains (SC) and related information technology systems (ITS) projects (Lyytinen and Hirschheim, 1987) . The aims of this paper are first, to address theoretical framework by bridging the gaps of different types of knowledge. Second, to establishing business requirements and the flow of information in supply chains between beneficiaries and solution providers in the long and complicated supply chains of the UK’s Health Sector. On the basis of brief introduction to knowledge, knowledge management and supply chain, the paper presents a practical framework that has been developed through critical and relevant literatures in the above three subject areas. Techniques and Tools stem from both management science and information systems were used to provide a possible solution for the problem in bridging the gaps of mismatch knowledge and understanding at the initial stage of identifying requirements in projects through knowledge sharing and transfer

Taking Tasers Seriously: The Need for Better Regulation of Stun Guns in New York

This report analyzes 851 Taser incident reports from eight police departments across the state as well as 10 departments' policies and guidelines for using the weapons, which deliver up to 50,000 volts of electricity and have caused the deaths of more than a dozen New Yorkers in recent years. The report concludes that police officers throughout New York State are consistently misusing and overusing Tasers

Effect of screening abdominal ultrasound examination on the decision to pursue advanced diagnostic tests and treatment in dogs with neurologic disease.

BackgroundAbdominal ultrasound examinations (AUS) are commonly performed before advanced neurodiagnostics to screen for diseases that might affect diagnostic plans and prognosis.ObjectivesDescribe the type and frequency of abnormalities found by AUS in dogs presenting with a neurological condition, identify risk factors associated with abnormalities, and evaluate treatment decisions based on findings.AnimalsSeven hundred and fifty-nine hospitalized dogs.MethodsRetrospective study. Medical records of dogs presented from 2007 to 2009 for neurologic disease were searched for signalment, neuroanatomic localization, and AUS findings. Whether dogs had advanced neurodiagnostics and treatment was analyzed.ResultsFifty-eight percent of dogs had abnormal findings on AUS. Probability of abnormalities increased with age (P < 0.001). Nondachshund breeds had higher probability of abnormal AUS than dachshunds (odds ratio [OR] = 1.87). Eleven percent of dogs did not have advanced neurodiagnostics and in 1.3%, this was because of abnormal AUS. Dogs with ultrasonographic abnormalities were less likely than dogs without to have advanced neurodiagnostics (OR = 0.3 [95% confidence interval [CI]: 0.17, 0.52]), however, the probability of performing advanced diagnostics was high regardless of normal (OR = 0.95 [95% CI: 0.92, 0.97]) or abnormal (OR = 0.85 [95% CI: 0.81, 0.88]) AUS. Treatment was more often pursued in small dogs and less often in dogs with brain disease.Conclusions and clinical importanceFindings from screening AUS had a small negative effect on the likelihood of pursuing advanced neurodiagnostics. Although it should be included in the extracranial diagnostic workup in dogs with significant history or physical examination abnormalities, AUS is considered a low-yield diagnostic test in young dogs and dachshunds

Continuous Nowhere Differentiable Functions

In this presentation we study functions that are continuous everywhere on their domain but differentiable nowhere.  One such function is the function whose graph is called the Kiesswetter curve.  First we construct the curve and the piece-wise function that represents that curve.  We prove several key properties of the function that gives us insight to why this function is continuous on the unit interval.  We then prove the continuity and nondifferentiability of the function

School gardening in early childhood education in Oman: a pilot project with grade 2 students

While school gardens are familiar in many Western contexts and research has reported significant pedagogical and affective is correct benefits of these resources, there is limited reporting of their use in non-western contexts. A pilot school gardening project involving a quasi-experimental mixed method design was undertaken in the Sultanate of Oman with several Grade 2 and Grade 7 classes to determine if this resource might provide benefits in this particular context. This paper reports on the findings for the Grade 2 cohort. While these findings were somewhat mixed and need to be treated tentatively given that the study was a pilot, they do suggest that school gardens in Oman could provide affective and possible health benefits for students. The potential health benefits could be particularly significant because the Omani population is beginning to exhibit a rapid increase in “lifestyle diseases,” most notably diabetes and cardiovascular illnesses. These illnesses appear to be linked to poor dietary habits and a more sedentary lifestyle among the younger generation

Introducing school gardens to the Omani context: a preliminary study with grade 7 classes

The Sultanate of Oman is beginning to experience a rapid increase in ‘lifestyle’ diseases, most notably diabetes and cardiovascular diseases. These may be linked to increasing poor dietary habits, and a more sedentary lifestyle, amongst the younger generation. In a number of Western contexts, school gardens have been shown to improve not only student attitudes to diet but also improved learning and affective outcomes. A pilot school gardening project involving a mixed method quasi-experimental design was undertaken in Oman with a number of Grade 7 classes. While the outcomes of this study should be treated tentatively, the quantitative findings indicate that employing school gardens as an educational resource might improve learning outcomes in the area of science skill development. The qualitative findings suggested that the project had a positive impact on the affective domain of students and in some cases encouraged them to pursue healthier eating habits

Altmetrics and the Scholarly Legacy

When using altmetrics to investigate the impact of a scholar's work, researchers and librarians are typically cautioned that altmetrics will be less useful for older works of scholarship. This is because it is difficult to collect social media and other attention retroactively, and the numbers will be lower if the work was published before social media marketing and promotion were widely accepted in a field. In this poster, we show that altmetrics can provide useful information about older works in the form of documenting renewed attention to past scholarship as part of a scholar's legacy. Using the PlumX profile of the late Dr. Thomas E. Starzl, often referred to as "the father of modern transplantation", we describe two cases where altmetrics provided information about renewed interest in his works: a controversy about race and genetics, and posthumous remembrances by colleagues of his contributions to a field

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH

Background Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug resistance and co-infection with HIV/AIDS. Tuberculosis control requires new drugs that act at novel drug targets to help combat resistant forms of Mycobacterium tuberculosis and reduce treatment duration. Methodology/Principal Findings Our approach was to modify the naturally occurring and synthetically challenging antibiotic thiolactomycin (TLM) to the more tractable 2-aminothiazole-4-carboxylate scaffold to generate compounds that mimic TLM's novel mode of action. We report here the identification of a series of compounds possessing excellent activity against M. tuberculosis H37Rv and, dissociatively, against the β-ketoacyl synthase enzyme mtFabH which is targeted by TLM. Specifically, methyl 2-amino-5-benzylthiazole-4-carboxylate was found to inhibit M. tuberculosis H37Rv with an MIC of 0.06 µg/ml (240 nM), but showed no activity against mtFabH, whereas methyl 2-(2-bromoacetamido)-5-(3-chlorophenyl)t​hiazole-4-carboxylateinhibited mtFabH with an IC50 of 0.95±0.05 µg/ml (2.43±0.13 µM) but was not active against the whole cell organism. Conclusions/Significance These findings clearly identify the 2-aminothiazole-4-carboxylate scaffold as a promising new template towards the discovery of a new class of anti-tubercular agents

Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research

INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp). METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [ RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests. DISCUSSION: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research. HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses

Unexpected Diagnosis of Both Adenocarcinoma of the Colon and Metastatic Lobular Carcinoma of the Breast in the Gastrointestinal Tract

Breast cancer rarely metastasises to the gastrointestinal tract. Lobular carcinoma more commonly metastasises to the uterus and appendages, peritoneum, and gastrointestinal tract than other types of breast cancer, while ductal carcinoma has a propensity to metastasise to the lungs, liver, and brain. We describe the case of a patient with no known history of breast cancer, whose primary presentation of lobular breast cancer was with malignant small intestinal and colonic strictures, with coexisting previously undiagnosed adenocarcinoma of the colon