4 research outputs found
PESTICIDAS: MECANISMO DE AÇÃO, DEGRADAÇÃO E TOXIDEZ
Este artigo apresenta breve revisão sobre pesticidas
muito utilizados no Brasil em culturas de soja, milho
e cana-de-açúcar. Foram abordados o mecanismo
de ação, a degradação e a toxidez dos herbicidas
glifosato, pendimetalina e atrazina e dos inseticidas
fenitrotion e fipronil. Verificou-se que o modo de ação
desses pesticidas ocorre por meio da inibição de
enzimas específicas como a enolpiruvil shikimato-
3-fosfato sintase (glifosato) e a colinesterase
(fenitrotion), de proteínas como as tubulinas
(pendimetalina), de receptores do sistema nervoso
como o ácido gama aminibutírico (fipronil) e da
inibição da fotossíntese (atrazina). Em relação à
degradação, a rota mais importante para o
desaparecimento dos herbicidas glifosato e atrazina
e do inseticida fenitrotion é a biodegradação. Fipronil,
moderadamente persistente no ambiente, é
degradado pela luz (fotodegradação). Para a
pendimetalina, tanto os microrganismos quanto a
luz são responsáveis pelo desaparecimento desse
composto. A toxidez dos pesticidas varia de acordo
com o grupo químico em que se enquadram, sendo
o efeito tóxico mais agudo para os seres humanos
e outros mamíferos apresentado pelo fenitrotion
(organofosforado)
Polymorphisms in the hypoxia-inducible factor 1 alpha gene in Mexican patients with preeclampsia: A case-control study
<p>Abstract</p> <p>Background</p> <p>Although the etiology of preeclampsia is still unclear, recent work suggests that changes in circulating angiogenic factors play a key role in its pathogenesis. In the trophoblast of women with preeclampsia, hypoxia-inducible factor 1 alpha (HIF-1α) is over-expressed, and induces the expression of non-angiogenic factors and inhibitors of trophoblast differentiation. This observation prompted the study of HIF-1α and its relation to preeclampsia. It has been described that the C1772T (P582S) and G1790A (A588T) polymorphisms of the <it>HIF1A </it>gene have significantly greater transcriptional activity, correlated with an increased expression of their proteins, than the wild-type sequence. In this work, we studied whether either or both <it>HIF1A </it>variants contribute to preeclampsia susceptibility.</p> <p>Results</p> <p>Genomic DNA was isolated from 150 preeclamptic and 105 healthy pregnant women. Exon 12 of the <it>HIF1A </it>gene was amplified by PCR, and the genotypes of <it>HIF1A </it>were determined by DNA sequencing.</p> <p>In preeclamptic women and controls, the frequencies of the T allele for C1772T were 4.3 vs. 4.8%, and the frequencies of the A allele for G1790A were 0.0 vs. 0.5%, respectively. No significant differences were found between groups.</p> <p>Conclusion</p> <p>The frequency of the C1772T and G1790A polymorphisms of the <it>HIF1A </it>gene is very low, and neither polymorphism is associated with the development of preeclampsia in the Mexican population.</p
Metabolic Glucose Status and Pituitary Pathology Portend Therapeutic Outcomes in Acromegaly
Proceedings of the 4th World Conference on Research Integrity
CITATION: O’Brien, S. P., et al. 2016. Proceedings of the 4th World Conference on Research Integrity. Research Integrity and Peer Review, 1:9, doi:10.1186/s41073-016-0012-9.The original publication is available at https://researchintegrityjournal.biomedcentral.comThese Proceedings contain the abstracts of the presentations given at the 4th World Conference in concurrent sessions, partner symposia, and poster sessions. Also included are summaries of the discussions in three focus tracks, which allowed delegates to consider and work on questions about the roles of funders, institutions, and countries in improving research systems and strengthening research integrity. Videos of the plenary presentations are available at the conference website (www.wcri2015.org).https://researchintegrityjournal.biomedcentral.com/articles/10.1186/s41073-016-0012-