Premature sexual initiation - a problem or an everyday occurrence for today's adolescents

Human sexuality is a component of a holistic being, a biopsychosocial state, defined by the World Health Organization as health. It is manifested in aspects of relationship, desire, sexual behavior, orientation, among others.  Every year, more and more reports say that the age of sexual initiation is shifting towards younger years. It is worth noting that, according to analyses, the sexuality of the young does not differ from that of the 20th century. In boys, the motivation to engage in sexual activity is usually lust, in girls it is love and emotion. This condition is influenced by many factors: biological, genetic, environmental, family, as well as psychological factors like personality and temperament. The health care system should promote appropriate sexual behavior, along with sex education and awareness of the consequences of risky behavior, including those related to venereal aspects

Design and assembling problems on the example of Denver’s international airport development and the possibility of solutions in design stage

In the paper a process of designing and assembling complicated steel structure is described. The object is a glass roof over the railroad terminal. The object’s body makes it impossible to assemble elements of the structure on the building site just having a structural 2D drawing. It was essential to create visual animation illustrating the chronology, in what way the particular elements of the structure should be assembled to achieve the effect assumed by the architects. However, the architectonic form of the whole object was so interesting and valuable that it is worth to destine investment means and time to achieve the desired aim

Media as a determinant of the sexuality of young Poles

Objective of the work: The aim of this study is to learn about the influence of the media on the sexuality of young Poles. Material and methods: The diagnostic survey method and the survey technique were used, based on the research tool which was the original questionnaire. 310 respondents, different in terms of sex, faith, place of residence and education, current family situation, aged from 16 to 21, participated in the study. Statistical analysis was carried out with the use of Exel 2019 and the SPSS Statisctics package, version 25, using the ANOVA analysis of variance and the Mann-Whitney and H Kruskal-Wallis t-tests. The data collection stage was carried out in the period from October to December 2019, via the Internet. Results and conclusions: Both men and women participating in the study view sexual, erotic and pornographic content in the mass media available to them, but women viewed pornographic content significantly less often than men. The main source of knowledge about sexuality for young Poles is the Internet. Television is relatively rare. Most of the respondents find it difficult to assess whether the media is a credible source of information on human sexuality. Most of the survey participants believe that the media content does not accelerate sexual initiation and does not affect their attitude towards sex. Believers were much less likely to support the credibility of mass media in the context of sexuality than non-believers. Key words: sexuality, sexual behavior, youth, medi

Search for ABCB1 modulators among 2-amine-5-arylideneimidazolones as a new perspective to overcome cancer multidrug resistance

Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (groups A and B), were designed and obtained in a three- or four-step synthesis, involving the Dimroth rearrangement. The new compounds were tested for their inhibition of the ABCB1 efflux pump in both sensitive (parental (PAR)) and ABCB1-overexpressing (MDR) T-lymphoma cancer cells in a rhodamine 123 accumulation assay. Their cytotoxic and antiproliferative effects were investigated by a thiazolyl blue tetrazolium bromide (MTT) assay. For active compounds, an insight into the mechanisms of action using either the luminescent Pgp-Glo™ Assay in vitro or docking studies to human Pgp was performed. The safety profile in vitro was examined. Structure–activity relationship (SAR) analysis was discussed. The most active compounds, representing both 2-substituted- (11) and Dimroth-rearranged 3-substituted (18) imidazolone topologies, displayed 1.38–1.46 fold stronger efflux pump inhibiting effects than reference verapamil and were significantly safer than doxorubicin in cell-based toxicity assays in the HEK-293 cell line. Results of mechanistic studies indicate that active imidazolones are substrates with increasing Pgp ATPase activity, and their dye-efflux inhibition via competitive action on the Pgp verapamil binding site was predicted in silico

Premature sexual initiation - a problem or an everyday occurrence for today's adolescents

Human sexuality is a component of a holistic being, a biopsychosocial state, defined by the World Health Organization as health. It is manifested in aspects of relationship, desire, sexual behavior, orientation, among others.  Every year, more and more reports say that the age of sexual initiation is shifting towards younger years. It is worth noting that, according to analyses, the sexuality of the young does not differ from that of the 20th century. In boys, the motivation to engage in sexual activity is usually lust, in girls it is love and emotion. This condition is influenced by many factors: biological, genetic, environmental, family, as well as psychological factors like personality and temperament. The health care system should promote appropriate sexual behavior, along with sex education and awareness of the consequences of risky behavior, including those related to venereal aspects

The level of physical activity in the lifestyle of physical education students

Subject: The level of physical activity in the lifestyle of physical education students Introduction: Physical activity is defined as voluntary and spontaneous physical activity practiced during leisure time. Thanks to it, the body can function properly and develop on many levels. It plays an important role in social and physical development, as well as intellectual and emotional development. It finds its place in the fight against civilization diseases, it is also beneficial in resisting many other diseases.    Aim: The aim of the article is to assess the level of physical activity of physical education students of various specializations.   Material and methods: The research was conducted among students of physical education at the University of Rzeszów. 60 people took part in them - 38 women and 22 men aged 19-30. The respondents answered anonymously to 18 closed, single-choice questions.   Results: The majority of students are engaged in physical activity outside a college, and 65% of it is at amateur level activity. The most common reason why respondents take up physical activity is to improve the functional fitness of the body. 58% of the respondents undertook physical activity more than 3 times a week.   Conclusions: Most of the respondents do physical activity outside of their studies. The most common reason for taking up physical activity among the respondents was the improvement of the functional fitness of the body, and the factors influencing the fact that students are physically active were to the greatest extent sports activitiesSubject: The level of physical activity in the lifestyle of physical education students Introduction: Physical activity is defined as voluntary and spontaneous physical activity practiced during leisure time. Thanks to it, the body can function properly and develop on many levels. It plays an important role in social and physical development, as well as intellectual and emotional development. It finds its place in the fight against civilization diseases, it is also beneficial in resisting many other diseases.   Aim: The aim of the article is to assess the level of physical activity of physical education students of various specializations.   Material and methods: The research was conducted among students of physical education at the University of Rzeszów. 60 people took part in them - 38 women and 22 men aged 19-30. The respondents answered anonymously to 18 closed, single-choice questions.   Results: The majority of students are engaged in physical activity outside a college, and 65% of it is at amateur level activity. The most common reason why respondents take up physical activity is to improve the functional fitness of the body. 58% of the respondents undertook physical activity more than 3 times a week.   Conclusions: Most of the respondents do physical activity outside of their studies. The most common reason for taking up physical activity among the respondents was the improvement of the functional fitness of the body, and the factors influencing the fact that students are physically active were to the greatest extent sports activities   Key words: physical activity; lifestyle; physical education; student

Selected school solutions in the field of a healthy lifestyle among children and adolescents

Introduction and aim: Lifestyle is the daily behaviors, habits and activities adopted by people. It is one of the factors that largely determines the state of human health. It is important to pay attention to what habits and activities we implement in our lives. The source of behaviors are usually attitudes and values acquired in the family and the nearest social environment. The basic categories of pro-health behaviours are related to physical health, psychosocial health, health prevention and avoiding harmful behaviours, preventing an illness and supporting recovery. Anti-health behaviors contribute to health disorders, negative impacts in emotional, physical and psychosocial sphere. The aim of the study was to present selected school solutions in the field of pro-healthy lifestyle among children and adolescents, the influence of pro-healthy lifestyle and assessment of the implementation of health education at schools. Material and method: 85 children and adolescents in the age range of 10-19+ years participated in the study. Twenty-three students in the age range of 10-12 years, 27 students in the age range of 13-16 years and 35 students in the age range of 17-19+ years were surveyed. Twenty-eight males and 57 females took the survey. Results: Respondents most often engage in physical activity 2-3 times per week. The vast majority of respondents actively participate in physical education classes at school as well as undertake extracurricular physical activity. The most popular activities are cycling and team games. The main source of knowledge about pro-healthy lifestyle among children and adolescents is the Internet and the least popular is the press. Conclusions: The majority of students know what a pro-healthy lifestyle is, while less than half of the respondents have no such knowledge. The researched gain knowledge about the way of promoting pro-healthy lifestyle by school, most often through the organization of "Health Day". The majority of children and adolescents participate in extracurricular physical activity, while the rest of the respondents do not undertake such activity

Construction of bionanoparticles with the use of a recombinant DNA vector-enzymatic system, containing artificial poliepitopic proteins, for the delivery of new generation vaccines

DNA/RNA amplification technologies, such as the Polymerase Chain Reaction have revolutionized modern biology, medical diagnostics and forensic analyses, among others. A number of alternative nucleic acids amplification methods have been developed, tailored to specific applications. Here we present a refined version of a DNA fragment amplification technology, which enables the construction of ordered concatemers in a head-to-tail-orientation. A very high number of DNA segments, at least 500 copies, can be consecutively linked. Other key features include: (i) the application of a dedicated vector-enzymatic system, including selected subtype IIS restriction endonucleases, which has been designed to automatically generate long Open Reading Frames and (ii) an amplification-expression vector with a built-in strong transcription promoter along with optimal translation initiation signals, which allow for a high level of expression of the constructed artificial poliepitopic protein. This highly advanced technology makes it possible to obtain ordered polymers of monomeric, synthetic or natural, DNA far beyond the capabilities of current chemical synthesis methods. The constructed poliepitopic proteins are further used for construction of several types of nanoparticles, including inclusion bodies and bacteriophages, containing multiple genetic fusion with poliepitopic proteins.The technology offers significant advances in a number of scientific, industrial and medical applications, including new vaccines and tissue pro-regenerative methods. The technology is protected by an international patent application and is available for licensing. Acknowledgments: project was supported by National Center for Research and Development, Warsaw, Poland, grant no STRATEGMED1/235077/9/NCBR/2014 and POIG.01.04.00-22-140/12; Jagiellonian Center for Innovation, Krakow, Poland; SATUS VC, Warsaw, Poland and BioVentures Institute Ltd, Poznan, Poland