31 research outputs found

    Limit Theorems for the Donsker Delta Function : an Example

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    Limit theorems of the type of the law of large numbers and the central limit theorem are established (in the sense of Hida distributions) for the composition of the Dirac distribution with the stochastic exponential of Brownian motion

    Law of large numbers and central limit theorem for Donsker's delta function of diffusions I

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    Limit theorems in the space of Hida distributions, similar to the law of large numbers and the central limit theorem, are shown for composites of the Dirac distribution with solutions of one-dimensional, non-degenerate Itô equations

    The Enskog process for hard and soft potentials

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    The density of a moderately dense gas evolving in a vacuum is given by the solution of an Enskog equation. Recently we have constructed in [ARS17] the stochastic process that corresponds to the Enskog equation under suitable conditions. The Enskog process is identified as the solution of a McKean-Vlasov equation driven by a Poisson random measure. In this work, we continue the study for a wider class of collision kernels that includes hard and soft potentials. Based on a suitable particle approximation of binary collisions, the existence of an Enskog process is established

    Multi-objective Optimisation of Multi-robot Task Allocation with Precedence Constraints

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    Efficacy of the multi-robot systems depends on proper sequencing and optimal allocation of robots to the tasks. Focuses on deciding the optimal allocation of set-of-robots to a set-of-tasks with precedence constraints considering multiple objectives. Taguchi’s design of experiments based parameter tuned genetic algorithm (GA) is developed for generalised task allocation of single-task robots to multi-robot tasks. The developed methodology is tested for 16 scenarios by varying the number of robots and number of tasks. The scenarios were tested in a simulated environment with a maximum of 20 robots and 40 multi-robot foraging tasks. The tradeoff between performance measures for the allocations obtained through GA for different task levels was used to decide the optimal number of robots. It is evident that the tradeoffs occur at 20 per cent of performance measures and the optimal number of robot varies between 10 and 15 for almost all the task levels. This method shows good convergence and found that the precedence constraints affect the optimal number of robots required for a particular task level

    MENCA experiment aboard India’s Mars Orbiter Mission

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    The Mars Exospheric Neutral Composition Analyser (MENCA) aboard the Indian Mars Orbiter Mission (MOM) is a quadrupole mass spectrometer-based experiment. Making use of the highly elliptical and low inclination (~150°) orbit of MOM, MENCA will conduct in situ measurements of the composition and radial distribution of the Martian neutral exosphere in the 1–300 amu mass range in the equatorial and low latitudes of Mars. The functionality of MENCA has been tested during the Earth-bound and heliocentric phases of MOM before its operation in the Martian orbit. This article describes the scientific objectives, instrument details, design and development, test and evaluation, and calibration of the MENCA instrument

    Repeat-Associated Fission Yeast-Like Regional Centromeres in the Ascomycetous Budding Yeast Candida tropicalis.

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    The centromere, on which kinetochore proteins assemble, ensures precise chromosome segregation. Centromeres are largely specified by the histone H3 variant CENP-A (also known as Cse4 in yeasts). Structurally, centromere DNA sequences are highly diverse in nature. However, the evolutionary consequence of these structural diversities on de novo CENP-A chromatin formation remains elusive. Here, we report the identification of centromeres, as the binding sites of four evolutionarily conserved kinetochore proteins, in the human pathogenic budding yeast Candida tropicalis. Each of the seven centromeres comprises a 2 to 5 kb non-repetitive mid core flanked by 2 to 5 kb inverted repeats. The repeat-associated centromeres of C. tropicalis all share a high degree of sequence conservation with each other and are strikingly diverged from the unique and mostly non-repetitive centromeres of related Candida species--Candida albicans, Candida dubliniensis, and Candida lusitaniae. Using a plasmid-based assay, we further demonstrate that pericentric inverted repeats and the underlying DNA sequence provide a structural determinant in CENP-A recruitment in C. tropicalis, as opposed to epigenetically regulated CENP-A loading at centromeres in C. albicans. Thus, the centromere structure and its influence on de novo CENP-A recruitment has been significantly rewired in closely related Candida species. Strikingly, the centromere structural properties along with role of pericentric repeats in de novo CENP-A loading in C. tropicalis are more reminiscent to those of the distantly related fission yeast Schizosaccharomyces pombe. Taken together, we demonstrate, for the first time, fission yeast-like repeat-associated centromeres in an ascomycetous budding yeast
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