Using data envelopment analysis for supplier evaluation with environmental considerations

With the proliferation of outsourcing in global market place, supplier selection has become a key strategic consideration in forming a competitive supply chain. Supplier selection has been recognized as a multi-criteria decision making problem in which suppliers are evaluated according to multiple criteria such as price, quality, delivery and service simultaneously. Facing with excessive pressures from government and customers, increasing number of companies are beginning to consider environmental issues in the procurement and supplier selection process to practice the sustainable development. It is therefore necessary to measure a supplier’s environmental performance. This paper aims to find out what kind of environmental criteria can be applied to assess suppliers overall performances. The multicriteria decision making approach data envelopment analysis (DEA) is applied to help companies to evaluate suppliers’ various environmental performance and other capabilities simultaneously. © 2013 IEEE.published_or_final_versio

CSR and environmental criteria in supplier selection

Session - Green Manufacturing Technology: paper no. M3C1The APIEMS 2012 Conference proceedings' website is located at http://apiems.net/conf2012/The supplier selection issue in today’s world does not simply depend on price anymore. Other non-price criteria such as quality, delivery and overall capability are gradually gaining equal importance. Because of the globalization of trade, the world is becoming an increasingly open and global marketplace where the intense competition is urging companies to reduce the cost and development time of a new product. Companies are forced to take every possible factor into consideration when making the strategic decision to minimize costs and product development time. That means besides taking price into consideration, companies now also has to assess the overall capability of the suppliers, such as production capability, technological capability, company reputation and other factors that are hard to be quantified, in order to make the most informed decision to strive for a balance between lowering profits and rising costs. Different companies have their own ways in carrying out the supplier selection process that aligns with their corporate strategy. This paper is interested in what criteria are used in supplier evaluation and the ranking of the criteria importance. In particular, the focus is the incorporation of corporate social responsibility (CSR) and environmental responsibility (ER) requirements into supplier selection. With the increasing awareness of CSR and ER, large international corporations have been paying more attention in selecting suppliers that are capable of adhering to the practice of sustainability. Hence, this paper aims to find out what criteria or performance indicators are adopted by companies to assess their suppliers, and how much importance CSR and ER contributes to the final decision of the selected supplier. A multi-agent system is implemented with a multi criteria decision making model to incorporate the criteria identified for evaluating supplier performance and selecting the most suitable supplier.published_or_final_versio

Dual fluorescence from aqueous 1-naphthylamine solutions of high pH - Excited-state acidic dissociation of naphthylamine

Dual fluorescence at ca. 447 nm and 545 nm was observed from the aqueous 1-naphthylamine (NA) solutions at pH higher than 13.6. Similar dual fluorescence was also found with sodium 1-naphthylaminoacetate(NAA), but not with N, N-disubstituted 1-aminonaphthalenes such as sodium 1-naphthylaminodiacetate (NADA) and 1-dimethylaminonaphthalene (DMAN). No change in absorption spectra of NA and NAA was observed in this pH region. It was proposed that the dual fluorescence observed with NA and NAA was due to the excited state dissociation of the primary and secondary amines at high pH. From the dual fluorescence intensity ratio pH titration curve, the pK(a)(.)'s of NA and NAA were estimated to be between 14 and 15 which are much lower than the ground state pK(a). The novel approach is such a simple, convenient and frequent analysis technique that it can be widely used in detecting the substitutional derivatives of aminonaphthalene

Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population

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Magnetic resonance imaging with pathological correlation in a case of mantle cell lymphoma of the parotid gland: a case report

<p>Abstract</p> <p>Introduction</p> <p>Mantle cell lymphoma is a rare non-Hodgkin's lymphoma. It is a subtype of B-cell lymphoma with frequent involvement of the bone marrow and the gastrointestinal tract. Isolated parotid gland involvement seldom occurs. Here we report an unusual case of isolated infiltration of the parotid gland by mantle cell lymphoma. The aim of our study is to correlate magnetic resonance imaging findings with the histological features of the disease. To the best of our knowledge, no similar radiological findings of mantle cell lymphoma have been published before.</p> <p>Case presentation</p> <p>A 72-year-old Caucasian woman presented with a painful left parotid enlargement. She was diagnosed with mantle cell lymphoma involving the left submandibular gland seven years prior to presentation. Her whole body CT scan showed the absence of pathologically enlarged lymph nodes. However, a magnetic resonance imaging showed enlargement of her left parotid gland and an abnormal parenchyma with mixed-type solid and cystic lesions. A biopsy of her left parotid gland and subsequent histological examination confirmed a mantle cell lymphoma (common variant) relapse.</p> <p>Conclusion</p> <p>Although rare, the involvement of parotid gland with mantle cell lymphoma must be considered in the differential diagnosis of parotid tumors.</p

A Study of Perturbations in Structure and Elastic Modulus of Bone Microconstituents Using Bimodal Amplitude Modulated-Frequency Modulated Atomic Force Microscopy

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Biomaterials Science and Engineering , copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsbiomaterials.8b01087The authors thank the financial support by National University of Singapore through the Eng-Med Seed Grant (R-265-000-532- 112) and Ministry of Education, Singapore, through National University of Singapore on Academic Research Funding (AcRF) R-265-000-495-112. Y.S. thanks the support of research scholarship from National University of Singapore

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation

Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second transmembrane domain (TM2) with those in P2X1 or P2X4. Replacement of the C-terminus of P2X7 with either P2X1 or P2X4 prevented surface expression of the chimeric receptor. Similarly, chimeric P2X7 containing TM2 from P2X1 or P2X4 had reduced surface expression and no permeability to cationic dyes. Exchanging the N-terminal 10 residues or C-terminal 14 residues of the P2X7 TM2 with the corresponding region of P2X1 TM2 partially restored surface expression and limited pore permeability. To further probe TM2 structure, we replaced single residues in P2X7 TM2 with those in P2X1 or P2X4. We identified multiple substitutions that drastically changed pore permeability without altering surface expression. Three substitutions (Q332P, Y336T, and Y343L) individually reduced pore formation as indicated by decreased dye uptake and also reduced membrane blebbing in response to ATP exposure. Three others substitutions, V335T, S342G, and S342A each enhanced dye uptake, membrane blebbing and cell death. Our results demonstrate a critical role for the TM2 domain of P2X7 in receptor function, and provide a structural basis for differences between purinergic receptors. © 2013 Sun et al

Can the Tumor Deposits Be Counted as Metastatic Lymph Nodes in the UICC TNM Staging System for Colorectal Cancer?

OBJECTIVE: The 7th edition of AJCC staging manual implicitly states that only T1 and T2 lesions that lack regional lymph node metastasis but have tumor deposit(s) will be classified in addition as N1c, though it is not consistent in that pN1c is also an option for pT3/T4a tumors in the staging table. Nevertheless, in this TNM classification, how to classify tumor deposits (TDs) in colorectal cancer patients with lymph node metastasis (LNM) and TDs simultaneously is still not clear. The aim of this study is to investigate the possibility of counting TDs as metastatic lymph nodes in TNM classification and to identify its prognostic value for colorectal cancer patients. METHODS AND RESULTS: In this retrospective study, 513 cases of colorectal cancer with LNM were reviewed. We proposed a novel pN (npN) category in which TDs were counted as metastatic lymph nodes in the TNM classification. Cancer-specific survival according to the npN or pN category was analyzed using Kaplan-Meier survival curves. Univariate and multivariate analyses were performed to identify significant prognostic factors. Harrell's C statistic was used to test the predictive capacity of the prognostic models. The results revealed that the TD was a significant prognostic factor in colorectal cancer. Univariate and multivariate analyses uniformly indicated that the npN category was significantly correlated with prognosis. The results of Harrell's C statistical analysis demonstrated that the npN category exhibited a superior predictive capacity compared to the pN category of the 7th edition TNM classification. Moreover, we also found no significant prognostic differences in patients with or without TD in the same npN categories. CONCLUSIONS: The counting of TDs as metastatic lymph nodes in the TNM classification system is potentially superior to the classification in the 7th edition of the TNM staging system to assess prognosis and survival for colorectal cancer patients

Design, synthesis and biological characterization of novel inhibitors of CD38

Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca 2+ messenger molecule, cyclic ADP-ribose, from NAD +. It is well established that this novel Ca 2+ signaling enzyme is responsible for regulating a wide range of physiological functions. Based on the crystal structure of the CD38/NAD + complex, we synthesized a series of simplified N-substituted nicotinamide derivatives (Compound1-14). A number of these compounds exhibited moderate inhibition of the NAD + utilizing activity of CD38, with Compound4 showing the highest potency. The crystal structure of CD38/Compound4 complex and computer simulation of Compound7 docking to CD38 show a significant role of the nicotinamide moiety and the distal aromatic group of the compounds for substrate recognition by the active site of CD38. Biologically, we showed that both Compounds4 and 7 effectively relaxed the agonist-induced contraction of muscle preparations from rats and guinea pigs. This study is a rational design of inhibitors for CD38 that exhibit important physiological effects, and can serve as a model for future drug development. © 2011 The Royal Society of Chemistry.postprin