10 research outputs found
Comparative evaluation of biochemical parameters during urinary infection in Maltese and Belgian shepherd dogs
Urinary tract infections can
be uncomfortable, painful and even
dangerous for most dog breeds. Clinical
signs are often nonspecific and insufficient
for diagnosis. Urinalysis in combination
with biochemical parameters and urine
culture is the best combination of clinical
findings for diagnosis of urinary tract
infections. The incidence of urinary tract
infections in dogs population is growing and
27% of dogs develop an urinary tract
infection through their life. Urinary
infections occur more often in the elderly
than in younger dogs. More than 70% of all
urinary tract infections are infections with
one bacterial species. Biochemical profile is
important aspect for diagnosis
establishment, but due to the nature of
action infection by different agents may be
considered as individual case. The main aim
of this research was to analyse biochemical
parameters of Maltese and Belgian
Shepherd (Malinois) dog breed, who were
affected by urinary tract infections. Urea
concentration was elevated in Malinois,
while urea, phosphates, albumins and
alkaline phosphatase activity were elevated
in Maltese dogs. Statistical analysis showed
differences in concentrations of urea,
creatinine, phosphates, so as alanine
aminotransferase, alkaline phosphatase and
amylase activity between compared breeds
during acute urinary infections. Maltese
dogs are less resistant to bacterias, that
causes urinary tract infections, and have
lower chance to maintain homeostasis of
biochemical parameters in blood during
urinary bacterial infections, in comparison
to Maltese dogs
Effects of trivalent and hexavalent dietary chromium on blood biochemical profile in Japanese quails
Trivalent chromium is an essential trace element for humans and animals and it is the final product of hexavalent chromium reduction in the cell. It is an integral part of the glucose-tolerance factor, which increases the systemic impact of insulin. The aim of this study was to analyse the effect of trivalent and hexavalent chromium on selected biochemical parameters in Japanese quails. Birds were divided into three groups: group I (control group, n=12), group II (treated with trivalent chromium, n=12) and group III (treated with hexavalent chromium, n=12). During 20 days of follow-up, control and ex-perimental groups of quails had identical diet; chromium was added daily into the food (5 mg/kg) and water (5 mg/L) of the experimental groups. Glucose concentrations were the highest in Group III, while lowest glucose concentrations were obtained in Group I. There were higher differencies regar¬ding blood biochemical parameters between control group and quails treated with Cr(VI). Our results showed that hexavalent chromium had negative effects on biochemical parameters in quails, while treatment with Cr(III) showed minor fluctuations in concentrations or activities of blood biochemical parameters
Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature
<p>Abstract</p> <p>Background</p> <p>Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.</p> <p>Methods</p> <p>We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.</p> <p>Results and discussion</p> <p>Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.</p> <p>Conclusion</p> <p>The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.</p
Comparative Evaluation of Biochemical Parameters During Urinary Infection in Maltese and Belgian Shepherd Dogs
Urinary tract infections can
be uncomfortable, painful and even
dangerous for most dog breeds. Clinical
signs are often nonspecific and insufficient
for diagnosis. Urinalysis in combination
with biochemical parameters and urine
culture is the best combination of clinical
findings for diagnosis of urinary tract
infections. The incidence of urinary tract
infections in dogs population is growing and
27% of dogs develop an urinary tract
infection through their life. Urinary
infections occur more often in the elderly
than in younger dogs. More than 70% of all
urinary tract infections are infections with
one bacterial species. Biochemical profile is
important aspect for diagnosis
establishment, but due to the nature of
action infection by different agents may be
considered as individual case. The main aim
of this research was to analyse biochemical
parameters of Maltese and Belgian
Shepherd (Malinois) dog breed, who were
affected by urinary tract infections. Urea
concentration was elevated in Malinois,
while urea, phosphates, albumins and
alkaline phosphatase activity were elevated
in Maltese dogs. Statistical analysis showed
differences in concentrations of urea,
creatinine, phosphates, so as alanine
aminotransferase, alkaline phosphatase and
amylase activity between compared breeds
during acute urinary infections. Maltese
dogs are less resistant to bacterias, that
causes urinary tract infections, and have
lower chance to maintain homeostasis of
biochemical parameters in blood during
urinary bacterial infections, in comparison
to Maltese dogs
Intraoperative transfusion practices in Europe
BACKGROUND:
Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe.
METHODS:
We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013.
RESULTS:
The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl(-1) and increased to 9.8 (1.8) g dl(-1) after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2).
CONCLUSION:
Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl(-1)), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold.
CLINICAL TRIAL REGISTRATION: NCT 01604083
Intraoperative transfusion practices in Europe
© 2016 The Author. Published by Oxford University Press on behalf of the British Journal of Anaesthesia.Background: Transfusion of allogeneic blood influences outcome after surgery. Despite widespread availability of transfusion guidelines, transfusion practices might vary among physicians, departments, hospitals and countries. Our aim was to determine the amount of packed red blood cells (pRBC) and blood products transfused intraoperatively, and to describe factors determining transfusion throughout Europe. Methods: We did a prospective observational cohort study enrolling 5803 patients in 126 European centres that received at least one pRBC unit intraoperatively, during a continuous three month period in 2013. Results: The overall intraoperative transfusion rate was 1.8%; 59% of transfusions were at least partially initiated as a result of a physiological transfusion trigger- mostly because of hypotension (55.4%) and/or tachycardia (30.7%). Haemoglobin (Hb)- based transfusion trigger alone initiated only 8.5% of transfusions. The Hb concentration [mean (sd)] just before transfusion was 8.1 (1.7) g dl-1 and increased to 9.8 (1.8) g dl-1 after transfusion. The mean number of intraoperatively transfused pRBC units was 2.5 (2.7) units (median 2). Conclusions: Although European Society of Anaesthesiology transfusion guidelines are moderately implemented in Europe with respect to Hb threshold for transfusion (7-9 g dl-1), there is still an urgent need for further educational efforts that focus on the number of pRBC units to be transfused at this threshold