Pautas a seguir para reducir el impacto del estrés calórico en la crianza artificial de terneros

Las altas temperaturas sumadas a la humedad ambiente producen en las crianzas artificiales de terneros situaciones de estrés calórico que muchas veces llegan a la muerte de los animales. El objetivo de este trabajo es brindar algunas pautas de manejo adecuado para que las personas dedicadas a la crianza puedan mitigar los efectos del estrés térmico.EEA Manfredi. AER San Francisco.Fil: Manelli, Daniel. SanCor Cooperativas Unidas Ltda.; ArtentinaFil: Suero, Marta María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Manfredi. Agencia de Extensión Rural San Francisco; ArgentinaFil: Centeno, A. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Manfredi. Agencia de Extensión Rural San Francisco; Argentin

Chemical composition, antibacterial and repellent activities of Azorella trifurcata, Senecio pogonias, and Senecio oreophyton essential oils

The antibacterial and insect-repellent activities of the essential oils (EOs) from Argentinian medicinal plants Azorella trifurcata (Gaertn.) Pers., Senecio cfr. oreophyton J. Remy and Senecio cfr. pogonias Cabrera, were investigated. All EOs showed good repellent properties against Triatoma infestans Klug, the vector of the Chagas disease, with percent repellence values between 60% and 70% at 24 hours compared with positive control N-N diethyl-m-methylbenzamide (DEET) and moderate activity against the bacteria tested with minimum inhibitory concentrations (MICs) values between 31.2 and 2000 μg/ml. The Azorella trifurcata, Senecio pogonias and S. oreophyton EOs, obtained by hydrodistillation, were characterized by GC-FID and GC/MS analyses. Spathulenol (38.2%), myrtenyl acetate (8.4%) and α-terpineol (4.5%), limonene (9.8%) and α-thujene (5.4%) were the main constituents in the EO of Azorella trifurcata. The Senecio pogonias and S. oreophyton EOs are characterized by a high content of monoterpenes hydrocarbons (92% and 95.1%, respectively) with α-pinene, the main component in both oils. To our knowledge, the essential oil composition from Andean medicinal plants A. trifurcata, Senecio pogonias and S. oreophyton collected in central Andean slopes are reported for first time.Fil: López, Sandra Beatriz. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Lima, Beatriz Viviana. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Agüero, María Belén. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López, María Liza. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hadad, Martín Ariel. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Caballero, Duilio. Provincia de San Juan. Hospital Marcial Quiroga; ArgentinaFil: Stariolo, Raúl Luis. Ministerio de Salud. Secretaría de Programas Sanitarios. Subsecretaría de Programas de Prevención y Promoción. Coordinación Nacional de Control de Vectores; ArgentinaFil: Suero, Eduardo. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentin

Una propuesta de proyecto interdisciplinar en la formación inicial del profesorado de Educación Infantil

Se presenta un proyecto interdisciplinar enmarcado en la asignatura de Formación Básica Salud Infantil: Educación motriz y artística de 12 créditos, correspondiente al primer curso de Grado de Educación Infantil, dentro del módulo Infancia, Salud y Alimentación; este proyecto surge por la necesidad de establecer un marco común de cohesión de las tres áreas implicadas: expresión corporal, musical y visual-plástica. La experiencia que aquí se presenta ha sido llevada a cabo en el periodo 2010-2017 en el Centro de Estudios Universitarios Cardenal Spínola CEU (centro adscrito a la Universidad de Sevilla). Con la intención de optimizar e integrar las tres áreas, el profesorado implicado propuso un tratamiento conjunto de la asignatura, en una colaboración interdisciplinar e interdepartamental. Bajo esta perspectiva, se realizaron procesos de diseño, organización, temporalización e implementación de la asignatura en paralelo, buscando la convergencia y favoreciendo la implementación del proyecto, como una zona común de las tres áreas. Se presenta la evolución del proyecto a lo largo de los siete años, los procesos metodológicos para su implementación y el material generado para la valoración y evaluación de las competencias de los estudiantes.Presents an interdisciplinary project framed in the course of training basic Child Health: motor and artistic education of 12 credits, corresponding to the first course of degree in Early Childhood Education, within the module for Children, Health and Nutrition; this project arises from the need to establish a common framework of cohesion of the three areas involved: corporal expression, musical and visual-plastic. The experience presented here has been carried out in the period 2010-2017 in the Center of University Studies Cardenal Spínola CEU (center attached to the University of Seville). With the intention to optimize and integrate the three areas, the teachers involved proposed a joint treatment of the subject, in an interdisciplinary and interdepartmental collaboration. Under this perspective, design processes, organization, timing and implementation of the subject in parallel, looking for the convergence and promoting the implementation of the project, such as a common area of all three parts. The evolution of the project over the seven years, the methodological processes for its implementation and the material generated for the assessment and evaluation of the competencies of the students

Laparoscopic vs. Open Approach in Emergent Inguinal Hernia: Our Experience and Review of Literature

There is currently no consensus or homogeneous recommendation about the role of the laparoscopic approach in emergent inguinal hernia surgery. The aim of this manuscript is showing our experience and results of laparoscopic approach for emergent groin hernia repair comparing with open approach. A retrospective review of a prospectively maintained database between January 2011 and December 2021 of acute incarcerated groin hernia that were operated at Virgen del Rocio University Hospital. In this period, they were identified 463 patients with groin hernia that required an emergency repair. 454 patients underwent open surgery (group 1) and 36 patients underwent laparoscopic approach (TAPP procedure) (group 2). Median length stay was 1 day in lap group and 2 days in open approach. Reintervention was necessary in 20 cases (4.40%) from group 1 and one (2.27%) from group 2. In laparoscopic approach, no mortality was described but in open approach, 10 patients (2.20%) died. Globally, 58 cases (12.77%) from group 1 and six patients (16.66%) from group 2 presented any complication. Wound infection was higher in group of open repairs (5.94% vs. 2.77%). Non-surgical complications were higher in open approach (19 vs. 0). There is no statistical significance in any of these items. Laparoscopic approach is a safe, feasible and effective therapeutic option for the treatment of incarcerated groin hernia that require emergency surgery, but prospective and randomized comparative studies are needed to establish the best approach

Influence of cytogenetic and molecular findings on prognosis and response to treatment of patients with acute myeloid leukemia

La mayoría de las determinaciones moleculares detalladas según la ELN2017 resultan de difícil acceso en nuestro medio y el cariotipo mantiene su importancia al indicar el tratamiento de los pacientes con leucemia mieloide aguda. Nuestro objetivo fue evaluar la influencia del cariotipo y de los hallazgos moleculares disponibles en relación a la supervivencia global (SG) y respuesta al tratamiento. Se realizó un análisis retrospectivo de 688 pacientes (pertenecientes a 11 instituciones, diagnosticados entre ene-13/jun-19), de los cuales 592 (86%) fueron evaluables. Los 196 pacientes (p) con cariotipo alterado, 104 (55%) vinculables a síndromes mielodisplásicos, mostraron una distribución heterogénea según los nueve sistemas aplicados (adverso: rango 47%-CECOG-SWOG-MDACC hasta 99%-Keating). La mayoría de los sistemas fueron útiles para predecir SG, con superioridad para el definido por CECOG-SWOG-MDACC (intermedio 10 m vs adverso 6 m, HR1,6 p=0,007) y entre aquéllos que recibieron un trasplante de células progenitoras hematopoyéticas (TCPH) (intermedio no alcanzada-NA vs adverso 14,5 m, HR2,5 p=0,053). En cuanto al tratamiento con agentes hipometilantes en 1ª línea (N 41, a fin de homogeneizar), excluyendo o no a los que recibieron TCPH (N 4), ninguno fue útil para diferenciar SG (9 m), tasas de remisiones completas (RC) ni mejor respuesta. Al evaluar quimioterapia, los sistemas CECOG-SWOG-MDACC y ELN2010 fueron los mejores predictores censurando (13 vs 8 m, p=0,023 y 15 vs 8 m, p=0,018) o no hasta el TCPH (p=0,009 y p=0,005). Sin embargo, sólo el primero fue útil para diferenciar tasas de RC (51/70, 73% vs 28/54, 52%, p=0,023). Finalmente, se compararon los hallazgos frente a la t(15;17) (N 77, SG NA) tomando la categorización del CECOG-SWOG-MDACC para los cariotipos alterados: CBF (N 65, SG NA) HR1,6 p=0,184; cariotipo-normal/NPM1+/FLT3- (N 26, SG NA) HR2,3, p=0,057; cariotipo-normal/NPM1-/FLT3- (N 102, SG 14 m) HR4,2, p<0,001; cariotipo-alterado/intermedio (N 101, 10 m) HR5,6, p<0,001; cariotipo-normal/NPM1-/FLT3+ (N 21, 9 m) HR6,1, p<0,001; cariotipo-alterado/adverso (N 88, 6 m) HR8,2, p<0,001 y cariotipo-normal/NPM1+/FLT3+ (N 12, SG 7 m) HR9,9, p<0,001 (CEPBA disponible en N 62, no evaluable). La mayoría de los riesgos se incrementaron al excluir los TCPH. Los resultados obtenidos comprueban el buen pronóstico de los pacientes con t(15;17), rearreglos CBF y de NPM1+ con cariotipo normal. Mientras que la detección de FLT3+ se asoció con un pronóstico adverso, independiente de NPM1+. El sistema definido por el CECOG-SWOG-MDACC, el cual considera de mal pronóstico a los cariotipos complejos y -5/-7, es el que mejor refleja los parámetros evaluados. Sin embargo, las alteraciones recomendadas por la ELN2010 reord3q, 5q-, t(6;9); 11q23v y 17p-, también influirían en la SG frente al tratamiento con quimioterapia en 1ª línea.The ELN2017 stratification has proved useful in predicting the outcome for acute myeloid leukemia (AML). However, some molecular determinations detailed are limited in use in our media and the karyotype remains an important factor regarding therapy. Our aim was to evaluate the predictive capacity of different cytogenetic and molecular findings on the outcome of patients with AML. Data was informative in 592 patients (pt) (from a retrospective cohort of 688 pt diagnosed in 11 Argentine centers between Jan/13-Jun/19). The overall survival (OS) concerning genetic data was different: t(15;17), 77 pt, not reached (NR); CBF rearrangements, 65 pt, NR; normal karyotype, 254 pt, 13 m, and abnormal karyotype, 196 pt, 8 m; p<0.001. Regarding normal karyotype, combined data according to the ELN2010 showed differences in the outcome: NPM1+/FLT3-, 26 pt, NR; NPM1-/FLT3- , 102 pt, 14 m; NPM1-/FLT3+, 21 pt, 9 m; NPM1+/ FLT3+, 12 pt, 7 m; p=0.025 (CEPBA available 62 pt, no evaluable). Adverse karyotypes were heterogeneously distributed among 9 systems: 47% CECOG-SWOGMDACC to 99% Keating-classification, and 104 (55%) with changes related to myelodysplastic syndromes. The CECOG-SWOG-MDACC showed superiority to differentiate between intermediate vs adverse for OS (10 vs 6 m, p=0.004; HR1.6, p=0.007, Cox’s regression) and, in the limit, for those who undergone hematopoietic stem cell transplantation (HSCT) (NA vs 15 m, p=0.033; HR 2.5, p=0.053). Regarding hypomethylating agents (41 pt) as first line therapy none was useful to differentiate OS (9 m), complete remission (CR) or best response. When chemotherapy was evaluated, the CECOG-SWOG-MDACC and ELN2010 were similar censoring (13 vs 8 m, p=0.023 and 15 vs 8 m, p=0.018) or not censoring at HSCT (14 vs 8 m, p=0.009, and 16 vs 8 m, p=0.005). However, only the first one made a difference in CR rates (73% vs 52%, p=0.023), with a tendency for any therapy (p=0.057). Finally, all findings were compared, selecting t(15;17) as reference and applying the CECOGSWOG-MDACC: CBF HR1.6 p=0.184; normal karyotype NPM1+/FLT3- HR2.3, p=0.057; normal karyotype NPM1-/FLT3- HR4.2, p<0.001; intermediate HR5.6, p<0.001; normal karyotype NPM1-/ FLT3+ HR6.1, p<0.001; normal karyotype NPM1+/ FLT3+ HR9.9, p<0.001, and adverse HR8.2, p<0.001. These HRs increased when excluding HSCT, especially for FLT3+. Our results are in agreement with the favorable outcome of t(15;17), CBF rearrangement and NPM1+/FLT3- in those with normal karyotype, whereas FLT3+ was an adverse finding. Complex karyotypes, -5 and -7, according CECOG-SWOGMDACC, were associated with shorter OS and lower CR. However, when rearr3q, 5q-, t(6;9), 11q23v and 17p- were also included, according to ELN2010, they account for a shorter OS in those treated with chemotherapyFil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Correa, Walter A.. Hospital Italiano; Argentina. Hospital Italiano de La Plata; ArgentinaFil: Gonzalez, Natalia Jacqueline. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; ArgentinaFil: Ferrari, Luciana. Fundación Para Combatir la Leucemia; ArgentinaFil: Dick, Hernán. Hospital Italiano de La Plata; ArgentinaFil: Cranco, Santiago. Instituto Alexander Fleming.; Argentina. Hospital Pediatrico Alexander Fleming; ArgentinaFil: Moirano, María. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martín; ArgentinaFil: Rapan, Leticia. Sanatorio “Sagrado Corazón”; ArgentinaFil: Oliveira, Natalia. Hospital Nacional Profesor Alejandro Posadas; ArgentinaFil: Kornblihtt, Laura Inés. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Suero, Alejandro. Unidad Asistencial "Dr. César Milstein"; ArgentinaFil: Navickas, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Gimenez Conca, Alberto. Hospital Italiano; Argentin

Leucemias Agudas

Sobre: Leucemia linfoblástica aguda; Linfoma linfoblástico; Leucemia mieloide aguda; Leucemia promielocítica aguda y situaciones especiales.Fil: Agriello, Evangelina Edith. No especifíca;Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Bullorsky, Laura. No especifíca;Fil: Cazap, Nicolás. No especifíca;Fil: Cranco, Santiago. No especifíca;Fil: Dick, Hernán. No especifíca;Fil: Fernandez, Isolda. No especifíca;Fil: Fischman, Laura. No especifíca;Fil: Funes, María Eugenia. No especifíca;Fil: Gimenez Conca, Alberto. No especifíca;Fil: González, Jacqueline. No especifíca;Fil: Lang, Cecilia. No especifíca;Fil: Mela Osorio, María José. No especifíca;Fil: Navickas, Alicia. No especifíca;Fil: Oliveira, Natalia. No especifíca;Fil: Rey, Irene. No especifíca;Fil: Rivas, Marta. No especifíca;Fil: Suero, Alejandro. No especifíca;Fil: Zanella, Lorena. No especifíca

Feedback-guided exercises performed on a tablet touchscreen improve return to work, function, strength and healthcare usage more than an exercise program prescribed on paper for people with wrist, hand or finger injuries: a randomised trial

Question In people with bone and soft tissue injuries of the wrist, hand and/or fingers, do feedback-guided exercises performed on a tablet touchscreen hasten return to work, reduce healthcare usage and improve clinical recovery more than a home exercise program prescribed on paper? Design Randomised, parallel-group trial with concealed allocation, assessor blinding and intention-to-treat analysis. Participants Seventy-four workers with limited functional ability due to bone and soft tissue injuries of the wrist, hand and/or fingers. Intervention Participants in the experimental and control groups received the same in-patient physiotherapy and occupational therapy. Participants in the experimental group received a home exercise program using the ReHand tablet application, which guides exercises performed on a tablet touchscreen with feedback, monitoring and progression. Participants in the control group were prescribed an evidence-based home exercise program on paper. Outcome measures The primary outcome was the time taken to return to work. Secondary outcomes included: healthcare usage (number of clinical appointments); and functional ability, pain intensity, and grip and pinch strength 2 and 4 weeks after randomisation. Results Compared with the control group, the experimental group: returned to work sooner (MD –18 days, 95% CI –33 to –3); required fewer physiotherapy sessions (MD –7.4, 95% CI –13.1 to –1.6), rehabilitation consultations (MD –1.9, 95% CI –3.6 to 0.3) and plastic surgery consultations (MD –3.6, 95% CI –6.3 to –0.9); and had better short-term recovery of functional ability and pinch strength. Conclusion In people with bone and soft-tissue injuries of the wrist, hand and/or fingers, prescribing a feedback-guided home exercise program using a tablet-based application instead of a conventional program on paper hastened return to work and improved the short-term recovery of functional ability and pinch strength, while reducing the number of required healthcare appointments

An Exercise and Educational and Self-management Program Delivered With a Smartphone App (CareHand) in Adults With Rheumatoid Arthritis of the Hands: Randomized Controlled Trial.

Rheumatoid arthritis (RA) is a prevalent autoimmune disease that usually involves problems of the hand or wrist. Current evidence recommends a multimodal therapy including exercise, self-management, and educational strategies. To date, the efficacy of this approach, as delivered using a smartphone app, has been scarcely investigated. This study aims to assess the short- and medium-term efficacy of a digital app (CareHand) that includes a tailored home exercise program, together with educational and self-management recommendations, compared with usual care, for people with RA of the hands. A single-blinded randomized controlled trial was conducted between March 2020 and February 2021, including 36 participants with RA of the hands (women: 22/36, 61%) from 2 community health care centers. Participants were allocated to use the CareHand app, consisting of tailored exercise programs, and self-management and monitoring tools or to a control group that received a written home exercise routine and recommendations, as per the usual protocol provided at primary care settings. Both interventions lasted for 3 months (4 times a week). The primary outcome was hand function, assessed using the Michigan Hand Outcome Questionnaire (MHQ). Secondary measures included pain and stiffness intensity (visual analog scale), grip strength (dynamometer), pinch strength (pinch gauge), and upper limb function (shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire). All measures were collected at baseline and at a 3-month follow-up. Furthermore, the MHQ and self-reported stiffness were assessed 6 months after baseline, whereas pain intensity and scores on the shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire were collected at the 1-, 3-, and 6-month follow-ups. In total, 30 individuals, corresponding to 58 hands (CareHand group: 26/58, 45%; control group: 32/58, 55%), were included in the analysis; 53% (19/36) of the participants received disease-modifying antirheumatic drug treatment. The ANOVA demonstrated a significant time×group effect for the total score of the MHQ (F1.62,85.67=9.163; P.05). Adults with RA of the hands who used the CareHand app reported better results in the short and medium term for overall hand function, work performance, pain, and satisfaction, compared with usual care. The findings of this study suggest that the CareHand app is a promising tool for delivering exercise therapy and self-management recommendations to this population. Results must be interpreted with caution because of the lack of efficacy of the secondary outcomes. ClinicalTrials.gov NCT04263974; https://clinicaltrials.gov/ct2/show/NCT04263974. RR2-10.1186/s13063-020-04713-4

The effects of a mobile app-delivered intervention in people with symptomatic hand osteoarthritis: a pragmatic randomized controlled trial

BACKGROUND: Exercise therapy, self-management and education are recommended interventions for hand osteoarthritis (OA), but new de- livery systems are needed to solve lack of adherence. AIM: To determine the effects on hand function and pain related measures of a mobile app-delivered intervention, compared with usual care, in patients with symptomatic hand OA. DESIGN: A pragmatic, multicenter, two-group parallel randomized controlled trial. SETTING: Community health centers in rural southern Spain. POPULATION: Eighty-three participants with unilateral or bilateral symptomatic hand OA were proposed to participate, and finally 74 were included and randomized. METHODS: Participants received a home multimodal treatment (exercise, education, and self-management recommendations) with the Care- Hand mobile app or usual care (written exercises) over 12 weeks. Monthly telephone calls were performed to monitor adherence. The primary outcome was hand physical function (Australian/Canadian Hand Osteoarthritis Index, AUSCAN) at 3- and 6-months. Secondary measures included hand pain intensity and morning stiffness, upper limb function, hand dexterity, and grip and pinch strength. RESULTS: The CareHand group showed significant within-group changes in hand function at 6-months (-3.0, 95% CI -5.1 to -0.9 vs. usual care: -0.9, 95% CI -3.3 to 1.5). Neither group showed improvements in hand function at 3-months (CareHand: -1.5, 95% CI -3.1 to 0.1; usual care: -0.5, 95% CI -2.7 to 1.7). For the secondary outcomes, the CareHand group showed better results on upper limb function both at 3- and 6-months, and on pain both at 1- and 3-months compared to usual care group. Linear regression models indicated that baseline scores of pain intensity, hand status, and upper limb function were associated with a greater improvement in hand pain and physical function. CONCLUSIONS: A mobile app-delivered intervention is effective for improving hand function, and better than usual care for upper limb function and pain. Further research is warranted to understand the impact of mobile health (mHealth) in people with hand OA. CLINICAL REHABILITATION IMPACT: mHealth interventions are a feasible and secure multimodal delivery approach in older adults with hand OA in rural primary care setting. Baseline pain and upper limb function might predict functional hand outcome