62 research outputs found
Совершенствование системы мотивации и стимулирования труда работников на примере ПАО "Ростелеком"
Объект ВКР - система мотивации и стимулирования персонала. Цель ВКР – изучение особенностей системы мотивации и стимулирования труда работников ПАО "Ростелеком" ,анализ применяемых методов мотивации и стимулирования и разработка рекомендаций. В результате исследования был разработан ряд мероприятий по совершенствованию системы мотивации и стимулирования персоналом.Object of WKR is a system of motivation and incentives for staff. The purpose of WKR is to study the features of the system of motivation and motivation of the work of PAO "Rostelecom" employees, analyze the methods of motivation and incentives used and develop recommendations. As a result of the research, a number of measures were developed to improve the system of motivation and incentives for staff
Genotype-phenotype relationships of truncating mutations, p.E297G and p.D482G in bile salt export pump deficiency
Background & Aims: Bile salt export pump (BSEP) deficiency frequently necessitates liver transplantation in childhood. Homozygous p.D482G or p.E297G mutations are associated with relatively mild phenotypes, responsive to surgical interruption of the enterohepatic circulation (siEHC), in contrast to patients with two predicted protein truncating mutations (PPTM). The phenotype of patients with a compound heterozygous genotype of one p.D482G or p.E297G mutation and one PPTM has remained unclear. We aimed to assess their genotype-phenotype relationship. Methods: From the NAPPED database, we selected patients with homozygous p.D482G or p.E297G mutations (BSEP1/1; n=31), with one p.D482G or p.E297G, and one PPTM (BSEP1/3; n=30), and with two PPTMs (BSEP3/3; n=77). We compared presentation, native liver survival (NLS), and effect of siEHC on NLS. Results: The groups had a similar median age at presentation (0.7-1.3 years). Overall NLS at age 10 years was 21% in BSEP1/3 vs. 75% in BSEP1/1 and 23% in BSEP3/3 (P<0.001). Without siEHC in their follow-up, NLS of BSEP1/3 was similar to BSEP3/3 patients, but considerably lower than BSEP1/1 patients (at age 10 years: 38%, 30%, and 71%, resp; P=0.003). After siEHC, BSEP1/3 and BSEP3/3 patients had similarly low NLS, while this was much higher in BSEP1/1 patients (10 years after siEHC, 27%, 14%, and 92%, resp.; P<0.001). Conclusions: BSEP deficiency patients with one p.E297G or p.D482G mutation and one PPTM have a similarly severe disease course and low responsiveness to siEHC as patients with two PPTMs. This identifies a considerable subgroup of patients who are unlikely to benefit from interruption of the enterohepatic circulation by either surgical or ileal bile acid transporter inhibitor treatment
Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes
Nuclear factor-κB regulates the expression of multiple genes encoding liver transport proteins
Rat lleal apical sodium-dependent bile acid transporter (ASBT): Carboxyl terminal 14 amino acids act as an apical sorting motif
Molecular cloning and functional analysis of the promoter for bile salt export pump (BSEP) from human and mouse genes: Evidence for transactivation of the humanpromoter by farnesoid-x-receptor/retinoid-x-receptor(FXR/RXR)
Cloning of the full-length cDNA for hamster liver Na-taurocholate cotransporting polypeptide (Ntcp) and functional analysis: Identification of two distinct transcripts
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