4 research outputs found
Cobalt-Catalyzed Hydroarylative Cyclization of 1,6-Enynes with Aromatic Ketones and Esters via C–H Activation
A highly
chemo- and stereoselective cobalt-catalyzed hydroarylative
cyclization of 1,6-enynes with aromatic ketones and esters to synthesize
functionalized pyrrolidines and dihydrofurans is described. A mechanism
involving cobaltacycle triggered C–H activation of aromatic
ketones and esters was proposed
Ligand-Controlled Divergent Cî—¸H Functionalization of Aldehydes with Enynes by Cobalt Catalysts
We
describe a highly step and atom economical cobalt-catalyzed
cyclization of 1,6-enynes with aldehydes to synthesize functionalized
pyrrolidines and dihydrofurans with high chemo- and stereoselectivity.
The catalytic reaction plausibly proceeds via the cobaltacycle intermediate
generated from the reaction of enyne substrate with cobalt catalyst,
followed by switchable Cî—¸H functionalization of weakly coordinating
aldehydes depending on the electronic nature of the ligand
Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction of 1,2,3-Benzotriazin-4(3<i>H</i>)‑ones with Organoboronic Acids: An Easy Access to <i>Ortho</i>-Arylated and Alkenylated Benzamides
A novel nickel-catalyzed approach
to synthesize <i>ortho</i>-arylated and alkenylated benzamides
in good to high yields via a
denitrogenative cross-coupling reaction of 1,2,3-benzotriazin-4Â(3<i>H</i>)-ones with organoboronic acids is described. The reaction
proceeds through a five-membered azanickelacyclic intermediate with
the extrusion of a nitrogen molecule. Moreover, the resulting <i>ortho</i>-arylated benzamides were successfully converted into
synthetically useful substituted fluorenones and <i>ortho</i>-arylated benzylamine derivatives in high yields
Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers
A nickel-catalyzed
highly regioselective 1,4-addition reaction
of boronic acids to dienones to form products with an all-carbon quaternary
center is described. The 3-alkenyl group of dienones is the key for
the reaction to proceed smoothly. A mechanism involving the coordination
of the dienyl group to the nickel center is proposed