Cobalt-Catalyzed Hydroarylative Cyclization of 1,6-Enynes with Aromatic Ketones and Esters via C–H Activation

A highly chemo- and stereoselective cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters to synthesize functionalized pyrrolidines and dihydrofurans is described. A mechanism involving cobaltacycle triggered C–H activation of aromatic ketones and esters was proposed

Ligand-Controlled Divergent CH Functionalization of Aldehydes with Enynes by Cobalt Catalysts

We describe a highly step and atom economical cobalt-catalyzed cyclization of 1,6-enynes with aldehydes to synthesize functionalized pyrrolidines and dihydrofurans with high chemo- and stereoselectivity. The catalytic reaction plausibly proceeds via the cobaltacycle intermediate generated from the reaction of enyne substrate with cobalt catalyst, followed by switchable CH functionalization of weakly coordinating aldehydes depending on the electronic nature of the ligand

Nickel-Catalyzed Denitrogenative Cross-Coupling Reaction of 1,2,3-Benzotriazin-4(3<i>H</i>)‑ones with Organoboronic Acids: An Easy Access to <i>Ortho</i>-Arylated and Alkenylated Benzamides

A novel nickel-catalyzed approach to synthesize <i>ortho</i>-arylated and alkenylated benzamides in good to high yields via a denitrogenative cross-coupling reaction of 1,2,3-benzotriazin-4­(3<i>H</i>)-ones with organoboronic acids is described. The reaction proceeds through a five-membered azanickelacyclic intermediate with the extrusion of a nitrogen molecule. Moreover, the resulting <i>ortho</i>-arylated benzamides were successfully converted into synthetically useful substituted fluorenones and <i>ortho</i>-arylated benzylamine derivatives in high yields

Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers

A nickel-catalyzed highly regioselective 1,4-addition reaction of boronic acids to dienones to form products with an all-carbon quaternary center is described. The 3-alkenyl group of dienones is the key for the reaction to proceed smoothly. A mechanism involving the coordination of the dienyl group to the nickel center is proposed