Cobalt-Catalyzed Hydroarylative Cyclization of 1,6-Enynes
with Aromatic Ketones and Esters via C–H Activation
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Abstract
A highly
chemo- and stereoselective cobalt-catalyzed hydroarylative
cyclization of 1,6-enynes with aromatic ketones and esters to synthesize
functionalized pyrrolidines and dihydrofurans is described. A mechanism
involving cobaltacycle triggered C–H activation of aromatic
ketones and esters was proposed