Selected problems/cases to stimulate collaborative learning regarding the dynamic flexibility of metabolism.

Resumen de la comunicación científicaMetabolic reprogramming has been identified as one of the hallmarks of cancer. Furthermore, it is becoming more and more frequent to establish connection between other diseases and metabolic rewiring. One of us has recently argued that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that allows it to continuously adapt to changes in the internal and external conditions [1]. Metabolism is considered by many students a remarkably difficult subject, due to its broad contents and the need of integrate them in a biologically meaningful manner. Collaborative learning strategies could contribute to make it easier for students to study metabolism. Since 2015, we design and use problem-based learning (PBL)-like exercises to help our students to study metabolism and its regulation. In the present communication, the experience with a PBL-like exercise devoted to show that reprogramming is a main hallmark of metabolism will be analyzed and discussed. This collaborative learning approach was monitored through comparisons between scores in pre- and post-tests of knowledge, perception and satisfaction questionnaires, evaluation of students’ final reports and final exam scores. Results show an overall high level of satisfaction and higher final exam scores by enrolled students, as compared to those of students that did not take part in these tasks.This work is supported by an Educative Innovation Project (PIE22-118, funded by University of Málaga). [Grants: PID2022-138181OB-I00, PID2019-105010RB-I00 and RTI2018-098560-BC22 (Spanish Government), UMA18-FEDERJA-220, and PY20_00257 (Andalusian Government and FEDER). Funds from BIO 267 (Andalusian Government)]. M.A.M. requested help form the «II Plan Propio de Investigación, Transference y Divulgación Científica de la UMA», Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

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International Conference on Computer, Information and Telecommunication Systems (7th, 2018, Colmar, Francia

Efecto de la excentricidad en nudos en superestructuras de armaduras espaciales mixtas de puentes (tridilosas)

The authors present a case study carried out to know the relevance, in the resistance of the bars, of the eccentricity in the joints of a bridge with mixed spatial truss superstructure. This type of superstructures was built in a significant number in Mexico, from its technological development. This technique was proposed by Ing. Heberto Castillo Martínez in the 1960s (1). Some of these superstructures are still in use. In this article, the case study is the Santo Domingo bridge, on the river of the same name located in Chiapas, Mexico. As a first phase, the superstructure is analyzed considering the concentric bars in the joints. In a second phase, the flexing moments generated by the eccentricity in the mid-height joints of the tridilose are taken into account. The resistance of critical elements is calculated considering separately the effects of the axial loads, of the bending moments caused by the own weight and the flexion in the slab and the bending moments caused by the eccentricity of the bars in the joints. The authors conclude that approximately half of the resistance of the bars is required to take the bending moments caused by the eccentricity of the bars in the joints.En este artículo se presenta el estudio efectuado para conocer la relevancia en la resistencia de las barras, de la excentricidad en los nudos de un puente con superestructura de armaduras espaciales mixtas. Este tipo de superestructuras de puentes fueron construidas en un número importante en México a partir de su desarrollo tecnológico propuesto por el Ing. Heberto Castillo Martínez en la década de 1960 del siglo XX [1]. Algunas de estas superestructuras aún siguen en uso. En este artículo, se presenta el puente Santo Domingo, sobre el río del mismo nombre ubicado en la Selva Lacandona de Chiapas, México. En una primera fase, se analiza la superestructura considerando las barras concentricas en los nudos y en una segunda fase se analiza tomando en cuenta los momentos flexionantes generados en las barras por la excentricidad en los nudos de media altura de la tridilosa. Se cálcula la resistencia de los elementos críticos considerando de manera separada los efectos de las cargas axiales, de los momentos flexionantes provocados por el peso propio y la flexión en la losa y los momentos flexionantes provocados por la excentricidad de las barras en los nudos. Se concluye mostrando que aproximadamente la mitad de la resistencia de las barras es requerida para tomar los momentos flexionantes provocados por la excentricidad de las barras en los nudos

Impact of CD68/(CD3+CD20) Ratio at the Invasive Front of Primary Tumors on Distant Metastasis Development in Breast Cancer

Tumors are infiltrated by macrophages, T and B-lymphocytes, which may favor tumor development by promoting angiogenesis, growth and invasion. The aim of this study was to investigate the clinical relevance of the relative amount of macrophages (CD68⁺), T-cells (CD3⁺ and B-cells (CD20⁺) at the invasive front of breast carcinomas, and the expression of matrix metalloproteases (MMPs) and their inhibitors (TIMPs) either at the invasive front or at the tumor center. We performed an immunohistochemical study counting CD3, CD20 and CD68 positive cells at the invasive front, in 102 breast carcinomas. Also, tissue sections were stained with MMP-2, -9, -11, -14 and TIMP-2 antibodies, and immunoreactivity location, percentage of reactive area and intensity were determined at the invasive front and at the tumor center. The results showed that an increased CD68 count and CD68/(CD3+CD20) ratio were directly associated with both MMP-11 and TIMP-2 expression by mononuclear inflammatory cells at the tumor center (p = 0.041 and p = 0.025 for CD68 count and p = 0.001 and p = 0.045 for ratio, respectively for MMP-11 and TIMP-2). In addition, a high CD68/(CD3+CD20) ratio (>0.05) was directly associated with a higher probability of shortened relapse-free survival. Multivariate analysis revealed that CD68/(CD3+CD20) ratio was an independent factor associated with distant relapse-free survival (RR: 2.54, CI: (1.23-5.24), p<0.01). Therefore, CD68/(CD3+CD20) ratio at the invasive front could be used as an important prognostic marker

El uso de proyectos de investigación como material docente

En este trabajo se explica el uso de los resultados de proyectos de investigación como herramienta para el profesorado como material docente. Actualmente, los docentes se implican en proyectos de investigación en los que se obtienen importantes avances y conocimientos que se divulgan por medio de artículos y conferencias. Los autores de este artículo utilizan los proyectos de investigación como material docente que aportará importantes ventajas al sistema. A través de un ejemplo práctico sobre estudiantes del Área de Ingeniería de la Construcción de diferentes titulaciones técnicas, en este artículo se identifican las ventajas y utilidades de estas herramientas

Diseño, Implantación y Desarrollo de un Máster en Ingeniería Informática

Este artículo describe el Máster en Ingeniería Informática de la Universidad de Oviedo, impartido en la Escuela Politécnica Superior de Ingeniería de Gijón (EPI). Es uno de los primeros estudios de máster en Ingeniería Informática implantados en España conforme a las Directrices del Consejo de Universidades para estudios conducentes a la profesión de Ingeniero en Informática (Resolución de 8 de junio de 2009, BOE 187, martes 4 de agosto de 2009).This paper provides an overview of the Informatics and Computing Engineering Master Degree at the Gijon Polytechnic School of Engineering (University of Oviedo). This is one of the earliest Informatics and Computing Engineering master’s in Spain designed according the National recommendations for the Informatics Engineering professio

Glycemic Variability and Its Association With Demographics and Lifestyles in a General Adult Population

Objective: The objective was to investigate glycemic variability indices in relation to demographic factors and common environmental lifestyles in a general adult population. Methods: The A Estrada Glycation and Inflammation Study is a cross-sectional study covering 1516 participants selected by sampling of the population aged 18 years and over. A subsample of 622 individuals participated in the Glycation project, which included continuous glucose monitoring procedures. Five glycemic variability indices were analyzed, that is, SD, MAGE, MAG, CONGA1, and MODD. Results: Participants had a mean age of 48 years, 62% were females, and 12% had been previously diagnosed with diabetes. In the population without diabetes, index distributions were not normal but skewed to the right. Distributional regression models that adjusted for age, gender, BMI, alcohol intake, smoking status, and physical activity confirmed that all indices were positively and independently associated with fasting glucose levels and negatively with heavy drinking. SD, MAGE, and CONGA1 were positively associated with aging, and MAG was negatively associated with BMI. None of the GVI studied were influenced by physical activity. Age-group-specific reference values are given for the indices. Conclusions: This study yielded age-specific reference values for glucose variability indices in a general adult population. Significant increases were observed with aging. Heavy drinking of more than 140 g/week was associated with significant decreases in variability indices. No differences were found between males and females. These normative ranges provide a guide for clinical care, and may offer an alternative treatment target among persons with diabetesThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research project was supported by grants from Spain’s Carlos III Institute of Health (Instituto de Salud Carlos III/ISCIII) (PI11/02219 & PI13/02594) and the European Regional Development Fund (FEDER). PDV and MAS were supported by ISCIII Preventive Activity & Health Promotion Research Network (Red de Investigación en Actividades Preventivas y de Promoción de Salud/redIAPP) grants RD06/0018/0006 & RD12/0005/0007, respectively. CCS has been partially supported by the Spanish Ministry of Science and Innovation (MTM2015-69068-REDT)S

Herramientas on-line (campus virtual) para el aprendizaje y autoevaluación de la asignatura Prótesis III en el Grado en Odontología.

Depto. de Odontología Conservadora y PrótesisFac. de OdontologíaFALSEsubmitte