Raw Garlic Consumption and Risk of Liver Cancer: A Population-Based Case-Control Study in Eastern China.

Although the major risk factors for liver cancer have been established, preventive factors for liver cancer have not been fully explored. We evaluated the association between raw garlic consumption and liver cancer in a large population-based case-control study in Eastern China. The study was conducted in Jiangsu, China, from 2003 to 2010. A total of 2011 incident liver cancer cases and 7933 randomly selected population-controls were interviewed. Epidemiological data including raw garlic intake and other exposures were collected, and serum markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were assayed. Overall, eating raw garlic twice or more per week was inversely associated with liver cancer, with an adjusted odds ratio (aOR) of 0.77 (95% confidence interval (CI): 0.62-0.96) compared to those ingesting no raw garlic or less than twice per week. In stratified analyses, high intake of raw garlic was inversely associated with liver cancer among Hepatitis B surface antigen (HBsAg) negative individuals, frequent alcohol drinkers, those having history of eating mold-contaminated food or drinking raw water, and those without family history of liver cancer. Marginal interactions on an additive scale were observed between low raw garlic intake and HBsAg positivity (attributable proportion due to interaction (AP) = 0.31, 95% CI: -0.01-0.62) and heavy alcohol drinking (AP = 0.28, 95% CI: 0.00-0.57). Raw garlic consumption is inversely associated with liver cancer. Such an association shed some light on the potential etiologic role of garlic intake on liver cancer, which in turn might provide a possible dietary intervention to reduce liver cancer in Chinese population

Structural and Thermodynamic Factors of Suppressed Interdiffusion Kinetics in Multi-component High-entropy Materials

We report multi-component high-entropy materials as extraordinarily robust diffusion barriers and clarify the highly suppressed interdiffusion kinetics in the multi-component materials from structural and thermodynamic perspectives. The failures of six alloy barriers with different numbers of elements, from unitary Ti to senary TiTaCrZrAlRu, against the interdiffusion of Cu and Si were characterized, and experimental results indicated that, with more elements incorporated, the failure temperature of the barriers increased from 550 to 900°C. The activation energy of Cu diffusion through the alloy barriers was determined to increase from 110 to 163 kJ/mole. Mechanistic analyses suggest that, structurally, severe lattice distortion strains and a high packing density caused by different atom sizes, and, thermodynamically, a strengthened cohesion provide a total increase of 55 kJ/mole in the activation energy of substitutional Cu diffusion, and are believed to be the dominant factors of suppressed interdiffusion kinetics through the multi-component barrier materials

Effect of insulin pump infusion on comprehensive stress state of patients with diabetic ketoacidosis

Purpose: To assess changes in the comprehensive stress state of patients with diabetic ketoacidosis (DKA) following treatment with insulin infusion pump.Methods: A total of 240 patients suffering from DKA who received treatment at The First Affiliated Hospital of Zhengzhou University from Feb. 2011 to Feb. 2014 were selected randomly and divided into a control group (120 cases), administered continuous intravenous insulin, and a treatment group (120 cases), administered insulin with an infusion pump. Relevant diabetes-associated serum indices, oxidative stress and stress hormone levels were compared between the groups at different time points.Results: Levels of glycosylated haemoglobin (HbAlc), fasting blood glucose (FBG) and anion gap (AG) were lower (p < 0.05) in the treatment group than in the control group at various time points. Carbon dioxide combining power (CO2-CP) and C-reactive peptide levels in the treatment group were higher (p < 0.05) than those of the control group at different time points. Except for the level of methane dicarboxylic aldehyde (MDA), the values of other oxidative stress indices were higher (p < 0.05) in the treatment group than in the control group at various time points. Moreover, the treatment group had lower serum cortisol (Cor) and noradrenalin (NA) levels and higher levels of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) than those of (p < 0.05).Conclusion: Insulin pump infusion effectively relieves the comprehensive stress state of patients suffering from DKA, and its therapeutic effect is superior to that of continuous instillation of low-dose insulin.Keywords: Diabetic ketoacidosis, Insulin pump, Comprehensive stress state, Blood glucose, Carbon dioxide combining power, C-reactive peptid

Enhanced Runoff Modeling by Incorporating Information from the GR4J Hydrological Model and Multiple Remotely Sensed Precipitation Datasets

Reliable runoff modeling is essential for water resource allocation and management. However, a key uncertainty source is that the true precipitation field is difficult to measure, making reliable runoff modeling still challenging. To account for this uncertainty, this study developed a two-step approach combining ensemble average and cumulative distribution correction (i.e., EC) to incorporate information from the GR4J (modèle du Génie Rural à 4 paramètres Journalier) hydrological model and multiple remotely sensed precipitation datasets. In the EC approach, firstly, the ensemble average is applied to construct transitional fluxes using the reproduced runoff information, which is yielded by applying various remotely sensed precipitation datasets to drive the GR4J model. Subsequently, the cumulative distribution correction is applied to enhance the transitional fluxes to model runoff. In our experiments, the effectiveness of the EC approach was investigated by runoff modeling to incorporate information from the GR4J model and six precipitation datasets in the Pingtang Watershed (PW; Southwest China), and the single precipitation dataset-based approaches and the ensemble average were used as benchmarks. The results show that the EC method performed better than the benchmarks and had a satisfactory performance with Nash–Sutcliffe values of 0.68 during calibration and validation. Meanwhile, the EC method exhibited a more stable performance than the ensemble averaging method under different incorporation scenarios. However, the single precipitation dataset-based approaches tended to underestimate runoff (regression coefficients < 1), and there were similar errors between the calibration and validation stages. To further illustrate the effectiveness of the EC model, five watersheds (including the PW) of different hydrometeorological features were used to test the EC model and its benchmarks. The results show that both the EC model and the ensemble averaging had good transferability, but the EC model had better performance across all the test watersheds. Conversely, the single precipitation dataset-based approaches exhibited significant regional variations and, therefore, had low transferability. The current study concludes that the EC approach can be a robust alternative to model runoff and highlights the value of the incorporation of multiple precipitation datasets in runoff modeling

Dietary Intake of Fatty Acids, Total Cholesterol, and Stomach Cancer in a Chinese Population.

To investigate the associations between dietary fatty acids and cholesterol consumption and stomach cancer (SC), we analyzed data from a population-based case-control study with a total of 1900 SC cases and 6532 controls. Dietary data and other risk or protective factors were collected by face-to-face interviews in Jiangsu Province, China, from 2003 to 2010. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multiple unconditional logistic regression models and an energy-adjusted method. The joint associations between dietary factors and known risk factors on SC were examined. We observed positive associations between dietary saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and total cholesterol and the development of SC, comparing the highest versus lowest quarters. Increased intakes of dietary SFAs (p-trend = 0.005; aOR, 1.11; 95% CI, 1.01-1.22 with a 7 g/day increase as a continuous variable) and total cholesterol (p-trend &lt; 0.001; aOR, 1.13; 95% CI, 1.06-1.22 with a 250 mg/day increase as a continuous variable) were monotonically associated with elevated odds of developing SC. Our results indicate that dietary SFAs, MUFAs, and total cholesterol are associated with stomach cancer, which might provide a potential dietary intervention for stomach cancer prevention

A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence. A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 was conducted based on the claims of Taiwan National Health Insurance Research Database. The use of acupuncture treatment and stroke recurrence were identified during the follow-up period from 2000 to 2009. This study compared the risk of stroke recurrence between ischemic stroke cohorts with and without acupuncture treatment by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of acupuncture associated with stroke recurrence in the Cox proportional hazard model. The stroke recurrence rate per 1000 person-years decreased from 71.4 without to 69.9 with acupuncture treatment (P &lt; 0.001). Acupuncture treatment was associated with reduced risk of stroke recurrence (HR 0.88; 95% CI 0.84-0.91). The acupuncture effect was noted in patients with or without medical treatment for stroke prevention but its impact decreased with aging of stroke patients. Compared with stroke patients without acupuncture treatment and medication therapy, the hazard ratios of stroke recurrence for those had medication therapy only, acupuncture only, and both were 0.42 (95% CI 0.38-0.46), 0.50 (95% CI 0.43-0.57), and 0.39 (95% CI 0.35-0.43), respectively. This study raises the possibility that acupuncture might be effective in lowering stroke recurrence rate even in those on medications for stroke prevention. Results suggest the need of prospective sham-controlled and randomized trials to establish the efficacy of acupuncture in preventing stroke