Subcortical brain atrophy persists even in HAART-regulated HIV disease

The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy

Regulatory Effect of Connexin 43 on Basal Ca2+ Signaling in Rat Ventricular Myocytes

Background: It has been found that gap junction-associated intracellular Ca 2+ [Ca 2+]i disturbance contributes to the arrhythmogenesis and hyperconstriction in diseased heart. However, whether functional gaps are also involved in the regulation of normal Ca 2+ signaling, in particular the basal [Ca 2+] i activities, is unclear. Methods and Results: Global and local Ca 2+ signaling and gap permeability were monitored in cultured neonatal rat ventricular myocytes (NRVMs) and freshly isolated mouse ventricular myocytes by Fluo4/AM and Lucifer yellow (LY), respectively. The results showed that inhibition of gap communication by heptanol, Gap 27 and flufenamic acid or interference of connexin 43 (Cx43) with siRNA led to a significant suppression of LY uptake and, importantly, attenuations of global Ca 2+ transients and local Ca 2+ sparks in monolayer NRVMs and Ca 2+ sparks in adult ventricular myocytes. In contrast, overexpression of rat-Cx43 in NRVMs induced enhancements in the above measurements, and so did in HEK293 cells expressing rat Cx43. Additionally, membrane-permeable inositol 1,4,5-trisphosphate (IP3 butyryloxymethyl ester) and phenylephrine, an agonist of adrenergic receptor, could relieve the inhibited Ca 2+ signal and LY uptake by gap uncouplers, whereas blockade of IP 3 receptor with xestospongin C or 2-aminoethoxydiphenylborate mimicked the effects of gap inhibitors. More importantly, all these gap-associated effects on Ca 2+ signaling were also found in single NRVMs that only have hemichannels instead of gap junctions. Further immunostaining/immunoblotting single myocytes with antibod

The Value Of Religion In Prison: An Inmate Perspective

In recent years, religious programming for inmates is being applauded by some as the latest answer to recidivism. Policy makers and correctional officials alike are among the supporters of these programs that go well beyond conventional prison ministry. The emphasis in promoting the expansion of religion-based programs indeed lies in the claim that faith in a higher power prevents relapse into criminal activity better than secular strategies. Whether this claim can be consistently validated remains unclear. Moreover, the sustained focus on religion\u27s utility in preventing future criminal conduct diminishes religion\u27s immediate value to the inmate during the term of incarceration. With this latter function in mind, this article reports findings from qualitative inquiries conducted in several prisons nationwide. Designed to reveal the meaning of religion to inmates, the study calls attention to the role of religion in preventing devaluation and fostering survival. © 2000, Sage Publications, Inc. All rights reserved

Religiousness, Race, and Psychological Well-Being: Exploring Social Psychological Mediators

Research and theory combine to suggest that the relationship between religious belief and psychological well-being should be more positive among Black than among White individuals. Further, this relationship should be mediated by social psychological aspects of religion that have positive implications for well-being, such as self-enhancing religious attributions and a positive social identity associated with one's religious affiliation. These predictions were examined in a sample of 66 Black and 59 White university students. Religious belief salience and psychological well-being were moderately positively correlated, but only among Black subjects. The relationship between religious belief and well-being was partially mediated by attributions to God that enhance life meaning and positive social identification resulting from one's religious affiliation, again only among Black subjects. Implications of these results for the self-maintenance of Black college students are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69072/2/10.1177_01461672952110004.pd