N-{3-[Bis(2-hydroxy­ethyl)amino­meth­yl]-5-nitro­phen­yl}benzamide

The title compound, C18H21N3O5, was prepared by the reaction of 3-benzamido-5-nitro­benzyl methane­sulfonate with diethano­lamine and is an inter­mediate in the synthesis of DNA minor-groove-binding polybenzamide agents capable of being conjugated to additional biologically active species. The asymmetric unit contains two independent mol­ecules, which differ only in the orientations of the hydroxy­ethyl groups. In the crystal structure, inter­molecular N—H⋯O and O—H⋯O hydrogen bonds link mol­ecules into one-dimensional chains

Software development and technical support for photogrammetric and cartographic data processing. HRSC-high resolution stereo camera experiment Mars-94 mission Final report

The acquisition and processing of planetary remote sensing data is commonly restricted to frame camera imagery. Since the development of multi-line sensors the three-dimensional multispectral data acquisition of planetary surfaces became possible. To use these data adequate photogrammetric and cartographic processing techniques are necessary. The goal of this project was to develop these techniques and to realize them in form of a software system. Based on the VICAR processing system it was the intention to do this yielding a nearly complete automization. By the development of several software components for image matching, the generation of Digital Terrain Models, Orthoimages, Image Mosaics and the sheets of a newly designed Topographic Image Map series these investigations succeded. The developments can be used for the Mars96 cameras HRSC and WAOSS as well as, with some adaptations, for these or other similar systems on upcoming planetary missions. The newly designed Topographic Image Map series in a scale of 1:200,000 was already appricated by the international community and is regarded as a representative for modern digital cartography. (orig.)SIGLEAvailable from TIB Hannover: F99B120+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany); DLR Deutsches Zentrum fuer Luft- und Raumfahrt e.V., Bonn (Germany)DEGerman

Lebenslanges Lernen: Lernzentrum fuer arbeitsplatz- und aufgabenorientierte Fortbildung in Kopplung mit einem virtuellen Weiterbildungszentrum Schlussbericht

SIGLEAvailable from TIB Hannover: F03B877 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman

Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma

Human papillomavirus-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is recognized as a distinct disease with unique etiology and clinical features. Current standard of care therapeutic modalities are identical for HPV+ and HPV− HNSCC and thus, there remains an opportunity to develop innovative pharmacologic approaches to exploit the inherent vulnerabilities of HPV+ HNSCC. In this study, using an inducible HPVE6E7 knockdown system, we found that HPV+ HNSCC cells are addicted to HPVE6E7, such that loss of these viral oncogenes impaired tumorigenicity in vitro and in vivo. A number of druggable pathways, including PPAR and Wnt, were modulated in response to HPVE6E7 loss. Fenofibrate showed significant anti-proliferative effects in a panel of HPV+ cancer cell lines. Additionally, fenofibrate impaired tumor growth as monotherapy and potentiated the activity of cisplatin in a pre-clinical HPV+ animal model. Systemic fenofibrate treatment induced p53 protein accumulation, and surprisingly, re-programmed the tumor-immune microenvironment to drive immune cell infiltration. Since fenofibrate is FDA-approved with a favorable long-term safety record, repositioning of this drug, as a single agent or in combination with cisplatin or checkpoint blockade, for the HPV+ HNSCC setting should be prioritized