Don’t fall in love with your method

Talk given during the "How To Be a Skeptical Neuroimager: Functional Connectivity & Causal Modeling" workshop at the 2011 Organization for Human Brain Mapping (OHBM) conference in in Quebec City, June 10-14

The globalization of world politics: an introduction to international relations (Fifth edition)

Now in its fifth edition, this internationally successful title has been fully revised and updated in light of recent developments in world politics. New chapters on post colonialism and post structuralism as well as increased emphasis on the global financial crisis, forced migration, diplomacy and religion ensure The Globalization of World Politics remains the most comprehensive introduction to International Relations available. Expert contributors provide accessible but stimulating insights into the history, theory, structures and key issues in IR, which are ideally suited to those coming to the subject for the first time. Students and lecturers are further supported by a cutting-edge Online Resource Centre

The globalization of world politics: an introduction to international relations (seventh edition)

'The Globalization of World Politics' is the market leading introduction to International Relations, written by an unrivalled line-up of experts in their fields. Spanning history, theory, structures and processes, and international issues, it offers the most comprehensive coverage of IR available and maps closely onto introductory courses, as well as being suitable as a valuable reference for the duration of an IR degree. Integrated learning features, including case studies and questions, a brand new debating feature and end of chapter questions, are all carefully tailored to the needs of students approaching IR for the first time. And new to this edition are four brand new chapters including: Feminism, Race, International Organizations, and NGOs

Threshold-Free Cluster Enhancement revisited: Increasing Power and Spatial specificity of TFCE

Poster submitted to the 2015 Organization for Human Brain Mapping (OHBM) in Hawaii, 14-18 June

APACE: Accelerated Permutation Inference for the ACE Model

Poster submitted to the 2014 Organization for Human Brain Mapping (OHBM) conference in Hamburg, 8-12 June

N‑Cadherin Targeted Melanin Nanoparticles Reverse the Endothelial–Mesenchymal Transition in Vascular Endothelial Cells to Potentially Slow the Progression of Atherosclerosis and Cancer

Endothelial–mesenchymal transition (EndoMT) of vascular endothelial cells has recently been considered as a key player in the early progression of a variety of vascular and nonvascular diseases, including atherosclerosis, cancer, and organ fibrosis. However, current strategies attempting to identify pharmacological inhibitors to block the regulatory pathways of EndoMT suffer from poor selectivity, unwanted side effects, and a heterogeneous response from endothelial cells with different origins. Furthermore, EndoMT inhibitors focus on preventing EndoMT, leaving the endothelial cells that have already undergone EndoMT unresolved. Here, we report the design of a simple but powerful nanoparticle system (i.e., N-cadherin targeted melanin nanoparticles) to convert cytokine-activated, mesenchymal-like endothelial cells back to their original endothelial phenotype. We term this process “Reversed EndoMT” (R-EndoMT). R-EndoMT allows the impaired endothelial barriers to recover their quiescence and intactness, with significantly reduced leukocyte and cancer cell adhesion and transmigration, which could potentially stop atheromatous plaque formation and cancer metastasis in the early stages. R-EndoMT is achieved on different endothelial cell types originating from arteries, veins, and capillaries, independent of activating cytokines. We reveal that N-cadherin targeted melanin nanoparticles reverse EndoMT by downregulating an N-cadherin dependent RhoA activation pathway. Overall, this approach offers a different prospect to treat multiple EndoMT-associated diseases by designing nanoparticles to reverse the phenotypical transition of endothelial cells

Introduction to global politics

The first U.S. textbook to offer students a truly global approach, Introduction to Global Politics brings together an expert team of international scholars who provide a current, engaging, non-U.S. perspective on international relations. The authors and editors help students to identify patterns, to apply theories, and to see "the whole chessboard" of global politics. The book's unique organization facilitates this global approach by dividing typical course coverage into several core areas of study--"Foundations," "Theories," "Actors," and "Issues"--allowing not only for maximum teaching flexibility but also for more thoughtful classroom discussions on various theories, transnational actors, and timely global issues. Adding interesting features and critical thinking questions throughout each chapter, the authors take the global approach one step further, encouraging students to develop their own informed worldviews

mRNA transcription of candidate genes for thermal adaptation in the crimson-spotted rainbowfish.

Total mRNA was extracted from laboratory bred and reared individuals (F1); parents were wild-caught and originated from the Brisbane River. At 6 months of age, individuals from each family group were subjected to one of two thermal treatments for a duration of 80 days. Rearing tank (Tank), sex (Sex), thermal treatment group (Treat) individual identifier (animal), parents (DAM & SIRE) and full-sib family group (Fam) are provided for each individual. Immediately following thermal treatment, fish were euthanized and total mRNA extracted from liver tissues. Transcript abundance was estimated via quantitative real-time PCR. LinRegPCR was used to convert raw CT values into estimates of initial/starting mRNA concentrations (N0). Initial mRNA concentrations were standardized relative to the geometric mean of two reference genes (geomean.REFS). Standardized values of candidate genes occupy the final 12 columns; gene symbols (column headings) are the same as those used in the accompanying article (McCairns et al. 2016)

A Method for Fast Whole-brain Aggregate Heritability Estimation

<div>Poster submitted to the 2014 Organization for Human Brain Mapping (OHBM) conference in Hamburg, 8-12 June.</div><div><br></div

Spectroscopic Imaging and Power Dependence of Near-Infrared to Visible Upconversion Luminescence from NaYF₄:Yb³⁺,Er³⁺ Nanoparticles on Nanocavity Arrays

The spatial variations in upconversion luminescence from NaYF₄:Er³⁺,Yb³⁺ nanoparticles embedded in PMMA on Au nanocavity arrays are investigated over a wide range of excitation powers, spanning the nonlinear and saturation power-dependence regimes. Spatially resolved upconversion spectra on these arrays show a minimum of ≈3× luminescence enhancement compared to the adjacent smooth Au surface under high-intensity excitation, with progressively higher enhancement ratios, up to 30×, at excitation intensities below 100 W/cm². It is found that the average upconversion luminescence enhancement, obtained by spectroscopic imaging and far-field measurements, can be almost entirely accounted for by an effective multiplicative shift in the excitation intensity, <i>P</i>_eff = <i>F</i>·<i>P</i>, which is robust over 5 orders of magnitude variation in excitation intensity. We reconcile this constant excitation enhancement factor, <i>F</i> = 4.46, with the wide range of observed luminescence enhancement factors, ranging from 3× to 30×, using an analytical model for a three level system, and by numerically solving a system of coupled rate equations for the Yb³⁺, Er³⁺ system. By analyzing the statistical distributions of luminescence intensities in the spectroscopic images on and off the nanocavity arrays, estimates of the luminescence enhancement factor independent of fluctuations in nanoparticle density are obtained. The results clearly relate observed enhancement factors to the kinetics of the energy-transfer upconversion process, suggesting the primary upconversion enhancement from these substrates is in the Yb³⁺ absorption channel, and demonstrate these self-assembled enhancing substrates as a low-cost and scalable route toward efficient near-infrared to visible upconversion at low excitation intensities