FABRICATION OF SODIUM ALGINATE/GUM GHATTI IPN MICROBEADS INTERCALATED WITH KAOLIN NANO CLAY FOR CONTROLLED RELEASE OF CURCUMIN

Objective: The objective of this study is to fabricate sodium alginate (SA)/gum ghatti (GG) microbeads intercalated with Kaolin (KA) nano clay for the sustained release of curcumin (CUR). Methods: The microbeads were prepared by a simple ionotropic gelation technique. The developed beads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Swelling studies and in vitro release studies were investigated under both pH 7.4 and pH 1.2 at 37 °C. Results: The developed microbeads were characterized by FTIR, which confirms the interaction between CUR, polymeric matrix and KA. DSC and XRD analysis reveals that the CUR has molecularly dispersed in the polymer matrix. In vitro results illustrated that microbeads were influenced by the pH of test media, which might be suitable for intestinal drug delivery. The drug release mechanism was analyzed by fitting the release data into different kinetic equations and n values are obtained in the range of 0.609-0.640, suggesting that the developed microbeads showed the non-Fickian diffusion type drug release. Conclusion: These results clearly illustrated that the developed KA intercalated polymeric microbeads are potential drug carriers for the controlled release of CUR

Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital

Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed. 

A new Analysis of Preventing DDOS attack by dynamic path identifiers in internet

We have exhibited the structure, execution and assessment of D-PID, a system that powerfully changes way identifiers (PIDs) of between space ways so as to anticipate DDoS flooding attacks, when PIDs are utilized as between area directing articles. We have depicted the plan subtleties of D-PID and actualized it in a 42-node model to confirm its attainability and viability

A New Multilevel Inverter Topology For High Step Up DC-DC Converter

High step up proportion dc–dc converters with megawatt evaluations are of enthusiasm for wind turbine interfaces and high-voltage direct current frameworks. This paper introduces a secluded multilevel dc–dc converter in view of the standard boost converter topology yet with the typical single switches supplanted by various capacitor-cinched sub modules. The converter is worked in resounding mode with reverberation between sub module capacitors and the arm inductor. A phase-shifted switching  course of action is connected with the end goal that there is a consistent number, i.e., N, of sub modules supporting the high voltage at once. In this operation mode, the progression up proportion is reliant on the quantity of sub modules and the inductor charging proportion. The converter shows versatility without utilizing a transformer and is equipped for bidirectional power stream. This venture is reached out to next sub module for expanding working scope of the converter. The outcomes checked through MATLAB/SIMULINK condition

Induction Motor Control With Small DC Link Capacitor Inverter Fed By Three Phase Diode Rectifier

This venture enhances the unwavering quality and power thickness of three stage variable speed drives by controlling presents a little film capacitor inverter based acceptance engine control . A hearty half and half engine controller is created to counteract execution corruption caused by the electrolytic capacitor-less inverter sustained by front-end diode rectifiers. The structure of the controller consolidates a model-based controller (MBC) and a hexagon voltage controlling controller (HVC). The MBC decides the order yield voltage with the convergence of the torque and rotor flux linkage charge. In the HVC mode, the order voltage vector is resolved just by the torque charge and the hexagon-formed inverter voltage limit. Fruitful utilization of the control approach is substantiated by a graphical and diagnostic implies that actually prompt a solitary voltage choice run the show. This paper additionally looks at the operation affectability under engine parameter floats to decide how to decouple its impact utilizing a voltage unsettling influence state-channel plan. This venture enhances the yield voltage and smoothening wave shapes by utilizing fluffy controller than PI controller. The outcomes checked through MATLAB/SIMULINK condition

Thin films of perfectly polar crystallites with uniaxial orientational ordering

The family of metal-organic complexes,(4-dialkylaminopyridyl)bis(acetylacetonato)zinc(II) which show perfectly polar assembly in the crystalline state are found to grow as orientationally ordered crystallites in vapor deposited thin films on glass substrates. A unique crystallographic axis of the crystallites, the longest unit cell axis in most cases, is oriented perpendicular to the substrate plane. The fact that the current observations cover a family of compounds is novel and of general significance for oriented thin film growth on amorphous substrates. Crystal structure, thin film morphology and second harmonic generation of a representative system are presented; the crystallites in the thin films do not show azimuthal orientational ordering

Performance Evaluation of Wi-Fi comparison with WiMAX Networks

Abstract Wireless networking has become an important area of research in academic and industry. The main objectives of this paper is to gain in-dept

Study - Comparison of two systems of classification of leprosy based on number of skin lesions and number of body areas involved - A clinicopathological concordance study

BACKGROUND AND AIMS: WHO guidelines classify leprosy patients for therapeutic purposes into paucibacillary (PB) and multibacillary (MB) leprosy based on the number of skin lesions. An alternative system of classification has been in practice in Nepal from 1985 onwards, based on the number of body areas involved in patients of leprosy. We attempted a clinicopathological approach for comparison of these two systems of classification in leprosy patients for their ability to demarcate patients into groups of PB and MB leprosy. MATERIALS AND METHODS: The study included 108 leprosy patients (80 males and 28 females). Complete clinical examination and body charting was carried out in each patient noting the count of skin lesions and the number of body areas involved. Slit skin smears and skin biopsies were taken from an active skin lesion in all patients. RESULTS: On analysis, it was observed that there was good clinicopathological correlation between patients with 5 or <5 skin lesions and 2 or <2 body areas involved. (Clinical 95% and histological 96%) A similar correlation was also observed in the other group of patients with > 5 skin lesions and > 2 body areas involved, (Clinical 94% and histological 96%). There were almost identical numbers of patients represented in these two groups of classification. CONCLUSIONS: Our findings suggest that patients with involvement of 2 or less body areas can be classified as PB leprosy and those with more than 2 body areas involved can be classified as MB leprosy for the purposes of therapy. The study of areas of involvement in leprosy patients not only provides additional patient information but also adds another parameter as a basis for the study of leprosy patients

The timing of death in patients with tuberculosis who die during anti-tuberculosis treatment in Andhra Pradesh, South India

Background: India has 2.0 million estimated tuberculosis (TB) cases per annum with an estimated 280,000 TBrelated deaths per year. Understanding when in the course of TB treatment patients die is important for determining the type of intervention to be offered and crucially when this intervention should be given. The objectives of the current study were to determine in a large cohort of TB patients in India:- i) treatment outcomes including the number who died while on treatment, ii) the month of death and iii) characteristics associated with “early” death, occurring in the initial 8 weeks of treatment. Methods: This was a retrospective study in 16 selected Designated Microscopy Centres (DMCs) in Hyderabad, Krishna and Adilabad districts of Andhra Pradesh, South India. A review was performed of treatment cards and medical records of all TB patients (adults and children) registered and placed on standardized anti-tuberculosis treatment from January 2005 to September 2009. Results: There were 8,240 TB patients (5183 males) of whom 492 (6%) were known to have died during treatment. Case-fatality was higher in those previously treated (12%) and lower in those with extra-pulmonary TB (2%). There was an even distribution of deaths during anti-tuberculosis treatment, with 28% of all patients dying in the first 8 weeks of treatment. Increasing age and new as compared to recurrent TB disease were significantly associated with “early death”. Conclusion: In this large cohort of TB patients, deaths occurred with an even frequency throughout anti-TB treatment. Reasons may relate to i) the treatment of the disease itself, raising concerns about drug adherence, quality of anti-tuberculosis drugs or the presence of undetected drug resistance and ii) co-morbidities, such as HIV/ AIDS and diabetes mellitus, which are known to influence mortality. More research in this area from prospective and retrospective studies is needed

Seed Systems for Rainfed Agriculture: Village Based Seed Enterprise for Seed Production and Dissemination of Improved Varieties of Chickpea and Pigeonpea in India; Information Bulletin No. 96

The crops grown under rainfed agriculture are described as farming practices that rely on rainfall for crop production and their seed systems describe, how farmers in these regions are sourcing seeds for cultivating these crops. The objective of this publication is to share information and experiences of some success stories of seed value chain models developed for production and supply of improved varieties of seed of rainfed crops to resource poor farmers in the semi-arid tropical regions to enhance productivity. Majority of legume crop varieties grown under rainfed agriculture system are open pollinated varieties or self-pollinated crops especially, cereals and legumes grown in semi-arid tropics of the globe. The importance of rainfed agriculture varies regionally but produces high percentage of food for poor communities in the developing countries. In sub-Saharan Africa more than 95% of the farmed land is rainfed, while the corresponding figure for Latin America is almost 90%, for South Asia it is about 60%, 65% for East Asia and 75% for the Near East and North Africa..