2,472 research outputs found
Against the Odds: Psychomotor Development of Children Under 2 years in a Sudanese Orphanage.
Providing abandoned children the necessary medical and psychological care as possible after their institutionalization may minimize developmental delays. We describe psychomotor development in infants admitted to an orphanage in Khartoum, Sudan, assessed at admission and over an 18-month follow-up. Psychological state and psychomotor quotients were determined using a simplified Neonatal Behavior Assessment Scale (NBAS), the Brunet-Lezine and Alarm distress baby (ADBB) scale. From May-September 2005, 151 children were evaluated 2, 4, 9, 12 and 18 months after inclusion. At admission, ∼15% of children ≤1 month had a regulation impairment according to the NBAS, and 33.8% presented a distress state (ADBB score >5). More than 85% (129/151) recovered normal psychomotor development. The results of the program reinforce the importance of early detection of psychological disorders followed by rapid implementation of psychological case management to improve the development of young children in similar institutions and circumstances
A phenomenological approach to the simulation of metabolism and proliferation dynamics of large tumour cell populations
A major goal of modern computational biology is to simulate the collective
behaviour of large cell populations starting from the intricate web of
molecular interactions occurring at the microscopic level. In this paper we
describe a simplified model of cell metabolism, growth and proliferation,
suitable for inclusion in a multicell simulator, now under development
(Chignola R and Milotti E 2004 Physica A 338 261-6). Nutrients regulate the
proliferation dynamics of tumor cells which adapt their behaviour to respond to
changes in the biochemical composition of the environment. This modeling of
nutrient metabolism and cell cycle at a mesoscopic scale level leads to a
continuous flow of information between the two disparate spatiotemporal scales
of molecular and cellular dynamics that can be simulated with modern computers
and tested experimentally.Comment: 58 pages, 7 figures, 3 tables, pdf onl
Ab Initio Study of Hybrid b-bar-gb Mesons
Hybrid b-bar-gb molecules in which the heavy b-bar-b pair is bound together
by the excited gluon field g are studied using the Born-Oppenheimer expansion
and numerical simulations. The consistency of results from the two approaches
reveals a simple and compelling physical picture for heavy hybrid states.Comment: 4 pages, 3 figures, uses REVTeX and epsf, final published versio
First Measurement of Monoenergetic Muon Neutrino Charged Current Interactions
We report the first measurement of monoenergetic muon neutrino charged
current interactions. MiniBooNE has isolated 236 MeV muon neutrino events
originating from charged kaon decay at rest ()
at the NuMI beamline absorber. These signal -carbon events are
distinguished from primarily pion decay in flight and
backgrounds produced at the target station and decay pipe
using their arrival time and reconstructed muon energy. The significance of the
signal observation is at the 3.9 level. The muon kinetic energy,
neutrino-nucleus energy transfer (), and total cross
section for these events is extracted. This result is the first known-energy,
weak-interaction-only probe of the nucleus to yield a measurement of
using neutrinos, a quantity thus far only accessible through electron
scattering.Comment: 6 pages, 4 figure
Analysis of a Large Sample of Neutrino-Induced Muons with the ArgoNeuT Detector
ArgoNeuT, or Argon Neutrino Test, is a 170 liter liquid argon time projection
chamber designed to collect neutrino interactions from the NuMI beam at Fermi
National Accelerator Laboratory. ArgoNeuT operated in the NuMI low-energy beam
line directly upstream of the MINOS Near Detector from September 2009 to
February 2010, during which thousands of neutrino and antineutrino events were
collected. The MINOS Near Detector was used to measure muons downstream of
ArgoNeuT. Though ArgoNeuT is primarily an R&D project, the data collected
provide a unique opportunity to measure neutrino cross sections in the 0.1-10
GeV energy range. Fully reconstructing the muon from these interactions is
imperative for these measurements. This paper focuses on the complete kinematic
reconstruction of neutrino-induced through-going muons tracks. Analysis of this
high statistics sample of minimum ionizing tracks demonstrates the reliability
of the geometric and calorimetric reconstruction in the ArgoNeuT detector
Investigating Multiple Candidate Genes and Nutrients in the Folate Metabolism Pathway to Detect Genetic and Nutritional Risk Factors for Lung Cancer
Purpose: Folate metabolism, with its importance to DNA repair, provides a promising region for genetic investigation of
lung cancer risk. This project investigates genes (MTHFR, MTR, MTRR, CBS, SHMT1, TYMS), folate metabolism related nutrients
(B vitamins, methionine, choline, and betaine) and their gene-nutrient interactions.
Methods: We analyzed 115 tag single nucleotide polymorphisms (SNPs) and 15 nutrients from 1239 and 1692 non-Hispanic
white, histologically-confirmed lung cancer cases and controls, respectively, using stochastic search variable selection (a
Bayesian model averaging approach). Analyses were stratified by current, former, and never smoking status.
Results: Rs6893114 in MTRR (odds ratio [OR] = 2.10; 95% credible interval [CI]: 1.20–3.48) and alcohol (drinkers vs. non-drinkers, OR = 0.48; 95% CI: 0.26–0.84) were associated with lung cancer risk in current smokers. Rs13170530 in MTRR (OR = 1.70; 95% CI: 1.10–2.87) and two SNP*nutrient interactions [betaine*rs2658161 (OR = 0.42; 95% CI: 0.19–0.88) and betaine*rs16948305 (OR = 0.54; 95% CI: 0.30–0.91)] were associated with lung cancer risk in former smokers. SNPs in MTRR (rs13162612; OR = 0.25; 95% CI: 0.11–0.58; rs10512948; OR = 0.61; 95% CI: 0.41–0.90; rs2924471; OR = 3.31; 95% CI: 1.66–6.59), and MTHFR (rs9651118; OR = 0.63; 95% CI: 0.43–0.95) and three SNP*nutrient interactions (choline*rs10475407; OR = 1.62; 95% CI: 1.11–2.42; choline*rs11134290; OR = 0.51; 95% CI: 0.27–0.92; and riboflavin*rs8767412; OR = 0.40; 95% CI: 0.15–0.95) were associated with lung cancer risk in never smokers. Conclusions: This study identified possible nutrient and genetic factors related to folate metabolism associated with lung cancer risk, which could potentially lead to nutritional interventions tailored by smoking status to reduce lung cancer risk
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