Using Scripture in Counselling Evangelicals

This thesis examines how the Bible can be used beneficially and ethically as a resource in counseling evangelicals. For evangelicals the Bible is their “primary text”—an unequalled source of authority and comfort. Evangelicals begin with the self-attestation of scripture to its own reliability and usefulness (e.g. 2 Tim. 3:16–17). When the scriptures are used in a responsible way using sound exegetical method there can be real dividends for the hearer. With proper preparation and informed consent, the counselor who ministers to evangelical clients can appropriate the message of the scriptures in a way that brings emotional and spiritual health. The responsible counselor uses the scriptures in an ethical way and does not apply them with insensitivity, imposition, or superstition. Three therapies are discussed and in each case, the scriptures can be integrated in a therapeutic way. In grief and loss counseling, clients identify with the deep meaning and emotions of the psalms of lament and find words for their grief. The scriptures give a “formfulness” to grief and overflow with candid speech to the God who saves. Scripture is also a vital part of biblically informed cognitive-behavioral therapy. Many emotional difficulties are mediated by dysfunctional thoughts. Scripture can be used in thought stopping, thought shaping, and cognitive disputation. In the Bible there are examples of various cognitive distortions: perfectionism, magnification, discounting the positive, mind reading, all or none thinking, et al. In post-modern therapies like solution-focused therapy and narrative therapy the therapist and client are looking for “grace-events”—places where God is already at work in the life of the client, providing solutions. When the dominant story is problem saturated, the Scriptures provide the client with exceptions to the problem and alternate stories of hope. The thesis concludes with directions for future research

Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer

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HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease.A Breast Cancer Campaign pilot grant awarded to E.M.H. supported this study. I.M.P. is supported by University of Hull HEFCE funding, and Royal Society and Breast Cancer Campaign pilot grants. S.A.E. is supported by ICR HEFCE funding and Cancer Research UK program grant C309/A11566. A.H. is supported by Brunel University HEFCE funding. E.M.H. is supported by a Cancer Research UK grant

18S is an appropriate housekeeping gene for in vitro hypoxia experiments

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Anomalous magnetotransport in wide quantum wells

We present magneto transport experiments of quasi 3D PbTe wide quantum wells. A plateau-like structure in the Hall resistance is observed, which corresponds to the Shubnikov de Haas oscillations in the same manner as known from the quantum Hall effect. The onsets of plateaux in Rxy do not correspond to 2D filling factors but coincide with the occupation of 3D (bulk-) Landau levels. At the same time a non-local signal is observed which corresponds to the structure in Rxx and Rxy and fulfils exactly the Onsager-Casimir relation (Rij,kl(B) = Rkl,ij(-B)). We explain the behaviour in terms of edge channel transport which is controlled by a permanent backscattering across a system of "percolative EC - loops" in the bulk region. Long range potential fluctuations with an amplitude of the order of the subband splitting are explained to play an essential role in this electron system.Comment: postscript file including 3 figs, 5 page