0-π\pi phase-controllable thermalthermal Josephson junction

Two superconductors coupled by a weak link support an equilibrium Josephson electrical current which depends on the phase difference $\varphi$ between the superconducting condensates [1]. Yet, when a temperature gradient is imposed across the junction, the Josephson effect manifests itself through a coherent component of the heat current that flows oppositely to the thermal gradient for $\varphi <\pi/2$ [2-4]. The direction of both the Josephson charge and heat currents can be inverted by adding a $\pi$ shift to $\varphi$. In the static electrical case, this effect was obtained in a few systems, e.g. via a ferromagnetic coupling [5,6] or a non-equilibrium distribution in the weak link [7]. These structures opened new possibilities for superconducting quantum logic [6,8] and ultralow power superconducting computers [9]. Here, we report the first experimental realization of a thermal Josephson junction whose phase bias can be controlled from $0$ to $\pi$. This is obtained thanks to a superconducting quantum interferometer that allows to fully control the direction of the coherent energy transfer through the junction [10]. This possibility, joined to the completely superconducting nature of our system, provides temperature modulations with unprecedented amplitude of $\sim$ 100 mK and transfer coefficients exceeding 1 K per flux quantum at 25 mK. Then, this quantum structure represents a fundamental step towards the realization of caloritronic logic components, such as thermal transistors, switches and memory devices [10,11]. These elements, combined with heat interferometers [3,4,12] and diodes [13,14], would complete the thermal conversion of the most important phase-coherent electronic devices and benefit cryogenic microcircuits requiring energy management, such as quantum computing architectures and radiation sensors.Comment: 10 pages, 9 color figure

Redescription of <i>Cercopithifilaria bainae</i> Almeida &amp; Vicente, 1984 (Spirurida, Onchocercidae) from a dog in Sardinia, Italy

Background Three species of the genus Cercopithifilaria have been morphologically and molecularly characterized in dog populations in southern Europe: Cercopithifilaria grassii (Noè, 1907), Cercopithifilaria sp. sensu Otranto et al., 2011 (reported as Cercopithifilaria sp. I), and Cercopithifilaria sp. II sensu Otranto et al., 2012. The adults of Cercopithifilaria sp. I have remained unknown until the present study. Methods The material originated from a dog from Sardinia (Italy) diagnosed with dermal microfilariae of Cercopithifilaria sp. I. The holotype and three paratypes of Cercopithifilaria bainae Almeida &amp; Vicente, 1984, described from dogs in Brazil, were studied as comparative material. A cox1 (~689 bp) and 12S (~330 bp) gene fragments were amplified and phylogenetic analysis carried out. Results The highest numbers of adult nematodes (82%) were collected in the sediment of the subcutaneous tissues of the trunk (n = 37) and forelimbs (n = 36). The morphology of the adult nematodes and microfilariae collected from the dog in Sardinia corresponded to those of C. bainae. All cox1 and 12S gene sequences showed a high homology (99-100%) with sequences from microfilariae of Cercopithifilaria sp. I. Conclusions The morphological and molecular identity of the microfilariae of C. bainae overlap those described previously as Cercopithifilaria sp. sensu Otranto et al., 2011 (=Cercopithifilaria sp. I). Therefore, the present study reports the occurrence of C. bainae in Europe, for the first time after its description and the single record in Brazil. C. bainae appears to be highly diffused in dog populations in southern Europe. The phylogenetic analyses based on cox1 and 12S do not reveal the three species of Cercopithifilaria parasitizing dogs as a monophyletic group, which suggests that they have derived independently by host switching

Minimally invasive triple valve surgery through a right minithoracotomy

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Pressure Dependence of Fragile-to-Strong Transition and a Possible Second Critical Point in Supercooled Confined Water

By confining water in nano-pores of silica glass, we can bypass the crystallization and study the pressure effect on the dynamical behavior in deeply supercooled state using neutron scattering. We observe a clear evidence of a cusp-like fragile-to-strong (F-S) dynamic transition. Here we show that the transition temperature decreases steadily with an increasing pressure, until it intersects the homogenous nucleation temperature line of bulk water at a pressure of 1600 bar. Above this pressure, it is no longer possible to discern the characteristic feature of the F-S transition. Identification of this end point with the possible second critical point is discussed.Comment: 4 pages, 3 figure

Estimation of Line Parameters, Tap Changer Ratios, and Systematic Measurement Errors Based on Synchronized Measurements and a General Model of Tap-Changing Transformers

A primary requirement for the transmission system operator is an accurate knowledge of grid parameters. Moreover, the availability of effective and accurate monitoring tools allows the proper operation of power transmission grids. However, in spite of the now widespread possibility of having monitoring systems based on synchronized measurements, the monitoring applications can be affected not only by the inevitable uncertainty sources but also by the simplified or incomplete modeling of the network components. For this reason, the impact on power system monitoring and control applications of tap-changing transformer models is a key point. In this scenario, this article presents a method to estimate simultaneously line parameters, tap changer ratios, and systematic measurement errors associated with the instrument transformers. The method exploits a flexible model of the tap-changing transformer based on a parameter representing the ratio between the two winding impedances of the transformer. The proposal is based also on the suitable modeling of the measurement chain and on the constraints introduced by the equations of involved transmissions lines and transformers. The validation has been carried out by means of tests performed on the IEEE 14 Bus Test Case

Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis

There is still no agreement on total plasma homocysteine (tHcy) role in age-related macular degeneration (AMD), the leading cause of new blindness in industrialized countries. We performed a systematic review and meta-analysis of the published data on the correlation between tHcy and AMD. MEDLINE/PubMed and ISI Web of Sciences searches were performed according to MOOSE guidelines. Case-control studies were eligible for inclusion. Participants and controls were AMD patients and subjects without AMD. The main outcome measure was wet AMD. Homocysteine level was the main exposure variable. Data were pooled using a random-effects model. Twelve case-control studies were identified: 10 assessed wet AMD, four dry AMD, one early AMD, one late AMD, and one any AMD. As for wet AMD, there was a total of 453 cases and 514 controls. Mean tHcy was on average 1.1 μmol/l (95% confidence interval [CI] = 0.96-1.25) greater in wet AMD cases, but there was evidence of extreme between-study heterogeneity (p &lt; 0.001, I2 = 91.8%). In a model homogenous for age, including six wet AMD studies (214 cases, 274 controls), mean tHcy was on average 0.58 μmol/l (95% CI = 0.35-0.73) greater in the case group, a not statistically significant result (p = 0.144) associated with moderate heterogeneity (I2 = 39.2%). Our meta-analysis indicates that there is some weak evidence that increased tHcy might be associated with wet AMD; however, this result should be interpreted cautiously, because of a marked between-study heterogeneity and the possible effect of publication bias. Future studies, preferably of cohort design, are necessary before any firm conclusions on the putative role of increased tHcy on AMD can be drawn

Refined Modeling and Compensation of Current Transformers Behavior for Line Parameters Estimation Based on Synchronized Measurements

Nowadays, in modern management and control applications, line parameters need to be known more accurately than in the past to achieve a reliable operation of the distribution grids. Phasor measurement units (PMUs) may improve line parameter estimation processes, but the accuracy of the result is affected by all the elements of the PMU-based measurement chain, in particular by the instrument transformers. Current transformers (CTs) are nonlinear and, therefore, their behavior is not easily described: their models cannot be straightforwardly included in the estimation problem. In this regard, this article refines modeling and compensation of CT systematic errors in line parameter estimation processes, based on different methods to describe the transformer behavior under various operating conditions. As the main result, the systematic errors of CTs are remarkably identified and mitigated. Moreover, the estimation of shunt susceptance values is significantly improved

Compensation of Systematic Errors for Improved PMU-based Fault Detection and Location in Three-Phase Distribution Grids

Grid management undoubtedly benefits from an accurate monitoring of actual network operating conditions. Such monitoring can be obtained starting from a widespread presence of measurement points and different types of estimation techniques. To exploit all the possible measurements present on the network, data coming from the protection systems can be considered in addition to those from the measurement systems. In this scenario, however, accuracy should not be underestimated, because in the presence of dynamic signals it can be dramatically reduced. In this context, this paper presents an improved fault detection and location method based on synchronized measurements, estimation techniques and an appropriate accuracy modeling aimed at reducing the uncertainty in the fault analysis. The proposed approach is validated by simulations carried out by means of a Digital Real Time Simulator (DRTS) on the three-phase CIGRE European Medium Voltage distribution networ

Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality worldwide. Patients with early-stage HCC can be treated successfully with surgical resection or liver transplantation. However, the usual late diagnosis of HCC precludes curative treatments, and systemic therapies are the only viable option for inoperable patients. Sorafenib, an orally available multikinase inhibitor, is a systemic therapy approved for treating patients with advanced HCC yet providing limited benefits. Consequently, new drugs have been developed to overcome sorafenib resistance and improve patients’ prognoses. A new promising strategy is using c-MET inhibitors, such as cabozantinib, as activation of c-MET occurs in up to 40% of HCC patients. In particular, cabozantinib, in combination with the checkpoint inhibitor atezolizumab, is currently in phase 3 clinical trial for HCC, and the results are eagerly awaited. Herein, we summarize and review the drugs approved for the treatment of advanced HCC, mainly focusing on the clinical and preclinical efficacy evaluation of cabozantinib. Also, we report the available preclinical data on cabozantinib-based combination therapies for HCC, current obstacles for cabozantinib therapy, and the future directions for cabozantinib-based treatment for HCC