Management of cervical cancer during pregnancy – a systematic review

Diagnosis of neoplasms during pregnancy and establishing a treatment schedule that is safe for both mother and fetus is problematic. This review summarizes knowledge about the problems associated with cervical cancer during pregnancy and current recommendations for diagnosis and treatment. The systematic review was performed according to PRISMA guidelines. The search was performed using PubMed, Scopus, Web of Science, and Google Scholar. Seven articles on 317 pregnant women with cervical cancer were included. Stage of disease, gestational age at diagnosis, treatment in pregnancy, type of delivery, gestational age of delivery, treatment after delivery, follow-up and main conclusion were analyzed. The rare phenomenon of neoplasms during pregnancy, as well as a limited research, do not allow for the development of clear guidelines for the treatment of cervical cancer in pregnant women. It is warrant to address discussed problems in future clinical research to provide the best care for pregnant cancer patients

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL-RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome