13 research outputs found
A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis
Funding: The study was supported by the European Cooperation in Science and Technology, who provided funds for publication. KMG is supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre and by the European Union's Seventh Framework Programme (FP7/2007-2013), projects Early Nutrition and ODIN under grant agreement numbers 289346 and 613977.Peer reviewedPublisher PD
A systematic review of maternal smoking during pregnancy and fetal measurements with meta-analysis
Background Maternal smoking during pregnancy is linked to reduced birth weight but the gestation at onset of this relationship is not certain. We present a systematic review of the literature describing associations between maternal smoking during pregnancy and ultrasound measurements of fetal size, together with an accompanying meta-analysis. Methods Studies were selected from electronic databases (OVID, EMBASE and Google Scholar) that examined associations between maternal smoking or smoke exposure and antenatal fetal ultrasound measurements. Outcome measures were first, second or third trimester fetal measurements. Results There were 284 abstracts identified, 16 papers were included in the review and the metaanalysis included data from eight populations. Maternal smoking was associated with reduced second trimester head size (mean reduction 0.09 standard deviation (SD) [95% CI 0.01, 0.16]) and femur length (0.06 [0.01, 0.10]) and reduced third trimester head size (0.18SD [0.13, 0.23]), femur length (0.27 SD [0.21, 0.32]) and estimated fetal weight (0.18 SD [0.11, 0.24]). Higher maternal cigarette consumption was associated with a lower z score for head size in the second (mean difference 0.09 SD [0, 0.19]) and third (0.15 SD [0.03, 0.26]) trimesters compared to lower consumption. Fetal measurements were not reduced for those whose mothers quit before or after becoming pregnant compared to mothers who had never smoked. Conclusions Maternal smoking during pregnancy is associated with reduced fetal measurements after the first trimester, particularly reduced head size and femur length. These effects may be attenuated if mothers quit or reduce cigarette consumption during pregnancy
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Details available from the studies used in the meta-analysis of the association between maternal smoking status and fetal ultrasound measurements.
<p>Details available from the studies used in the meta-analysis of the association between maternal smoking status and fetal ultrasound measurements.</p
Summary of meta-analyses relating maternal smoking to absolute and standardised second and third trimester fetal measurements.
<p>Summary of meta-analyses relating maternal smoking to absolute and standardised second and third trimester fetal measurements.</p
Mean z scores for femur length, abdominal circumference and biparietal diameter for fetuses exposed to maternal smoking relative to non-exposed fetuses.
<p>The vertical lines correspond to 95% confidence intervals.</p
Summary of results from the papers identified in the systematic review.
<p>Summary of results from the papers identified in the systematic review.</p