533 research outputs found
Changing channels
Scientists agree: flood damages will increase dramatically across Europe
over the coming decades. And as extreme rainfall events happen again
and again, some places will be hit harder than others. So why is it that
some areas are becoming more prone to flooding, and others not?
Louise Slater explains why collecting data on river flows is so important
in our efforts to find out
Regulation of Human Rhinovirus Induced Type I Interferon-beta, Type III Interferon-lambda and Pro-Inflammatory Cytokine Gene Expression in Normal Human Bronchial Epithelial Cells
Asthma is an economically important disease, with exacerbations causing significant
morbidity and morality. Viral infections cause ~80% of asthma exacerbations; the
majority of which are attributed to rhinovirus infection. How rhinovirus infection leads to
an acute asthma exacerbation is incompletely understood. The up-regulation of proinflammatory
cytokines/chemokines from rhinovirus infected bronchial epithelial cells
and an impaired ability of rhinovirus infected asthmatic bronchial epithelial cells to
produce type I interferon-β and type III interferon-λs, are believed to contribute. This
study aimed to investigate differences in the signalling requirements of rhinovirusinduced
pro-inflammatory cytokines/chemokines from those of IFN-β/IFN-λ. The viral
pattern recognition receptors, signalling intermediates and transcription factors required
by rhinovirus to induce pro-inflammatory cytokine/chemokine and IFN-β/IFN-λ
expression were explored using short interfering RNA, constitutive activation/overexpression
of signalling molecules and IFN-β promoter reporter mapping experiments.
The viral pattern recognition receptors RIG-I, MDA5 and TLR3 were required for
rhinovirus-induced pro-inflammatory cytokines IL-8/CXCL8, ENA-78/CXCL5, IL-6
RANTES/CCL5, IP-10/CXCL10 and IFN-β expression. Only MDA5 and TLR3 are
required for rhinovirus-induced IFN-λ expression. Whilst having common signalling
intermediates, the adaptor protein TRAF6, the kinases JNK2 and PI3Kα and the
transcription factor NF-kB p65 were not required for rhinovirus-induced IFN-β/λ
expression, but were required for rhinovirus induction of some/all of the proinflammatory
cytokines measured. IRF3 was the only transcription factor identified to be
commonly required for rhinovirus-induced expression of IFN-β and IFNλ-s. These
findings support the hypothesis that the induction of IFN-β/λ and pro-inflammatory
cytokines/chemokines, by rhinovirus, requires one or more distinct signalling molecules,
and/or transcription factors. TRAF6, JNK2, PI3Kα and NF-kB p65 are potential novel
therapeutic targets for rhinovirus-induced asthma exacerbations, the inhibition of which
may suppress the detrimental actions of pro-inflammatory cytokines/chemokines without
inhibiting IFN-β/λ production in asthmatic bronchial epithelial cells
Recommended from our members
Deploying teaching assistants to support learning: from models to typologies
The deployment of Teaching Assistants (TAs) to support learning has been the subject of much critical debate, including the particular concern that TAs too often becomes a less skilled replacement for the teacher rather than acting as an additional source of support. Despite efforts to encapsulate the TAs contribution to learning within specific models of deployment, wide variations in practices make the role and its contribution to learning difficult to define. Drawing on data gathered in four secondary schools in England, this paper explores TA deployment practices through six typologies: The Island; The Container; The Separate Entity; The Conduit for Learning; The Partner and The Expert. Illustrated graphically, these bring key elements together in a more contextualised and dynamic way. The paper concludes that the spatial and relational dimensions of deployment warrant more nuanced treatment and that more emphasis on partnership and mutuality and rather less on difference and hierarchy might be productiv
Understanding heatwave-drought compound hazards and impacts on socio-ecosystems
As the Earth warms, the frequency and severity of weather and climate-related extremes are steadily increasing in most regions worldwide. A critical concern is the simultaneous occurrence of climatic extremes in the same location, referred to as compound events. Among these, Heatwave-Drought Compound Events (HDCEs) are one of the most destructive hazards, exacerbating impacts on human societies and ecosystems more than individual extremes. Therefore, it is necessary to understand the physical mechanisms behind HDCEs and to project their future changes and implications for socio-ecosystems. In this Perspective, we explain the motivation for understanding HDCE dynamics, describe new protocols to explore the water-heat-carbon coupling processes driving HDCEs, and finally outline future changes in HDCEs as well as their impacts on economic development and the carbon cycle
Contribution of anthropogenic activities to the intensification of heat index-based spatiotemporally contiguous heatwave events in China
In this study, we identified heat index (HI)-based spatiotemporally contiguous heatwaves (HI-STHWs) in China based on meteorological observations and CMIP6 global climate model simulations. We analyzed the spatiotemporal patterns of changes in HI-STHWs in the past and future and quantitatively attributed these changes to anthropogenic activities. The results show that the duration, severity, average, maximum, and total impacted area of the annual strongest HI-STHWs during the present period of 1991–2014 are 1.77, 2.0, 1.05, 1.14, and 1.89 times the historical period of 1961–1990, respectively. In the fingerprint results, the anthropogenic greenhouse gases (GHG) signal is significantly detected, while the aerosol (AER) and natural (NAT) signals are not. GHG is the primary factor driving the intensification of HI-STHWs, which alone explains about 130%, 122%, 112%, 111%, and 114% of the above changes. The reason for GHG contribution exceeding 100% is that AER might have a negative contribution although nonsignificant. In the future warming climate, anthropogenic activities are projected to lead to more unprecedented HI-STHWs. Under the high emissions scenario of SSP585, by 2100, the annual strongest HI-STHW in China is projected to last almost the whole year and influence 96% regions of China in the most serious day. Meanwhile, its duration and total impacted area are 24.5 [17.2, 31.6] (90% confidence interval) and 107.2 [70, 129.9] times the preindustrial period. However, if the warming level could be limited to 2/1.5 °C, those values would be 3.4/5.4 and 8.2/16.2 times smaller than that under the SSP585 scenario by 2100
Climatology of flooding in the United States
Flood losses in the United States have increased dramatically over the course of the past century, averaging US$7.96 billion in damages per year for the 30-year period ranging from 1985 to 2014. In terms of human fatalities, floods are the second largest weather-related hazard in the United States, causing an average of 82 deaths per year between 1986 and 2015. Given the wide-reaching impacts of flooding across the United States, the evaluation of flood-generating mechanisms and of the drivers of changing flood hazard are two areas of active research. Flood events can be driven by a variety of physical mechanisms, including rain and snowmelt, frontal systems, monsoons, intense tropical cyclones, and more generic cyclonic storms. However, flood frequency analysis has traditionally been based on statistical analyses of the observed flood distributions that rarely distinguish among these physical flood-generating processes. In reality, flood frequency distributions are often characterized by ‘mixed populations’ arising from multiple flood-generating mechanisms, which can be challenging to disentangle. Temporal changes in the frequency and magnitude of flooding have also been the subject of a large body of work in recent decades. The science has moved from a focus on the detection of trends and shifts in flood peak distributions towards the attribution of these changes, with particular emphasis on climatic and anthropogenic factors, including urbanisation and changes in agricultural practices. A better understanding of these temporal changes in flood peak distributions, as well as of the physical flood-generating mechanisms, will enable us to move forward with the estimation of future flood design values in the context of both climatic and anthropogenic change
Enhancing the predictability of seasonal streamflow with a statistical-dynamical approach
Seasonal streamflow forecasts facilitate water allocation, reservoir operation, flood risk management, and crop forecasting. They are generally computed by forcing hydrological models with outputs from general circulation models (GCMs) or using large-scale climate indices as predictors in statistical models. In contrast, hybrid statistical-dynamical forecasts (combining statistical methods with dynamical climate predictions) are still uncommon and their skill is largely unknown. Here, we conduct systematic forecasting of seasonal streamflow using eight GCMs from the North-American
Multi-Model Ensemble, 0.5-9.5 months ahead, at 290 streamgauges in the U.S. Midwest.
Probabilistic forecasts are developed for low to high streamflow using predictors that reflect climatic and anthropogenic influences. Results indicate that GCM forecasts of climate and antecedent climatic conditions enhance seasonal streamflow predictability; while land cover and population density predictors decrease biases or enhance skill in certain catchments. This paper paves the way for novel forecasting approaches using dynamical GCM predictions within statistical frameworks
Examination of changes in annual maximum gage height in the continental United States using quantile regression
This study focuses on the detection of temporal changes in annual maximum gage height (GH) across the continental United States and their relationship to changes in short- and long-term precipitation. Analyses are based on 1805 U.S. Geological Survey records over the 1985-2015 period and are performed using quantile regression. Trends were significant only at a limited number of sites, with a higher number of detections at the tails of the distribution. Overall, we found only weak evidence that the annual maximum GH records have been changing over the continental United States during the past 30 years, possibly due to a weak signal of change, large variability, and limited record length. In addition to trend detection, we also assessed to what extent these changes can be attributed to storm total rainfall and long-term precipitation. Our findings indicate that temporal changes in GH maxima are largely driven by storm total rainfall across large areas of the continental United States (east of the 100th meridian, U.S. West Coast). Long-term precipitation accumulation, on the other hand, is a strong flood predictor in regions where snowmelt is an important flood generating mechanism (e.g., northern Great Plains, Rocky Mountains), and is overall a relatively less important predictor of extreme flood events
Evaluating the drivers of seasonal streamflow in the U.S. Midwest
Streamflows have increased notably across the U.S. Midwest over the past century, fueling a debate on the relative influences of changes in precipitation and land cover on the flow distribution. Here we propose a simple modeling framework to evaluate the main drivers of streamflow rates. Streamflow records from 290 long-term USGS stream gauges were modeled using five predictors: precipitation, antecedent wetness, temperature, agriculture, and population density. We evaluated which predictor combinations performed best for every site, season and streamflow quantile. The goodness-of-fit of our models is generally high and varies by season (higher in the spring and summer than in the fall and winter), by streamflow quantile (best for high flows in the spring and winter, for low flows in the fall, and good for all flow quantiles in summer), and by region (better in the southeastern Midwest than in the northwestern Midwest). In terms of predictors, we find that precipitation variability is key for modeling high flows, while antecedent wetness is a crucial secondary driver for low and median flows. Temperature improves model fits considerably in areas and seasons with notable snowmelt or evapotranspiration. Last, in agricultural and urban basins, harvested acreage and population density are important predictors of changing streamflow, and their influence varies seasonally. Thus, any projected changes in these drivers are likely to have notable effects on future streamflow distributions, with potential implications for basin water management, agriculture, and flood risk management
On the impact of gaps on trend detection in extreme streamflow time series
Streamflow time series often contain gaps of varying length and location. However, the influence of these gaps on trend detection is poorly understood and cannot be estimated a priori in trend-detection studies. We simulated the effects of varying gap size (1, 2, 5, and 10 years) and location (one quarter, one third, and half of the way) on the detection rate of significant monotonic trends in annual maxima and peaks-over-threshold, based on the most commonly-used trend tests in time series of varying length (from 15 to 150 years) and trend magnitude (β1). Results show that, in comparison with the complete time series, the loss in trend detection rate tends to grow with (i) increasing gap size, (ii) increasing gap distance from the middle of the time series, (iii) decreasing β1 slope, and (iv)
decreasing time series length. Based on these findings, we provide objective recommendations and cautionary remarks for maximal gap allowance in trend detection in extreme streamflow time series
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